Electrical Stimulation of Myoblast Proliferation and Differentiation on Aligned Nanostructured Conductive Polymer Platforms

Quigley, Anita; Razal, Joselito M.; Kita, Magdalena; Jalili, Rouhollah; Gelmi, Amy; Penington, Anthony; Ovalle‐Robles, Raquel; Baughman, Ray H.; Clark, Graeme M.; Wallace, Gordon G.; Kapsa, Robert M. I.

doi:10.1002/adhm.201200102

Cited by 68 publications

(60 citation statements)

References 47 publications

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“…Meanwhile, conducting polymers with good biocompatibility is widely applied in biomedical area such as biomedical imaging [45], biosensor [46,47], artificial muscle [48], drug release controller [49], cancer biomarker [50] and neural interface [51,52]. One of the most important roles conducting polymer plays is in the electrode-tissue interface material for neural engineering, as it can be facilely fabricated into multiple structures [53], modified by different doping [54,55] and regulated to undertake electrical stimulation [56,57].…”

Section: Electrode-tissue Interface For Neural Interfacementioning

confidence: 99%

Progress in Research of Flexible MEMS Microelectrodes for Neural Interface

Tang¹,

Tian²,

Kang³

et al. 2017

Preprint

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Abstract:With the rapid development of MEMS (Micro-electro-mechanical Systems) fabrication technologies, manifolds microelectrodes with various structures and functions have been designed and fabricated for applications in biomedical research, diagnosis and treatment through electrical stimulation and electrophysiological signal recording. The flexible MEMS microelectrodes exhibit multi-aspect excellent characteristics beyond stiff microelectrodes based on silicon or SU-8, which comprising: lighter weight, smaller volume, better conforming to neural tissue and lower fabrication cost. In this paper, we mainly reviewed key technologies on flexible MEMS microelectrodes for neural interface in recent years, including: design and fabrication technology, flexible MEMS microelectrodes with fluidic channels and electrode-tissue interface modification technology for performance improvement. Furthermore, the future directions of flexible MEMS microelectrodes for neural interface were described including transparent and stretchable microelectrodes integrated with multi-aspect functions and next-generation electrode-tissue interface modifications facilitated electrode efficacy and safety during implantation. Finally, the combinations among micro fabrication techniques with biomedical engineering and nanotechnology represented by flexible MEMS microelectrodes for neural interface will open a new gate to human lives and understanding of the world.

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Section: Electrode-tissue Interface For Neural Interfacementioning

confidence: 99%

Progress in Research of Flexible MEMS Microelectrodes for Neural Interface

Tang¹,

Tian²,

Kang³

et al. 2017

Preprint

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show abstract

“…To mimic the natural structure of nerves and muscles best, fibrous structures in the macro-, micro-and nanodomains have been used to provide scaffold support to regenerating tissues. The fibre structures had positive effects on the regeneration and growth of nerve and muscle cells, providing support and direction, either with or without electrical stimulation (Bini et al 2006;Matsumoto et al 2000;Quigley et al 2012;Razal et al 2009). …”

Section: Introductionmentioning

confidence: 97%

From nanoparticles to fibres: effect of dispersion composition on fibre properties

et al. 2015

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A polyvinyl alcohol (PVA)-stabilized polypyrrole nanodispersion has been optimised for conductivity and processability by decreasing the quantity of PVA before and after synthesis. A reduction of PVA before synthesis leads to the formation of particles with a slight increase in dry particle diameter (51 ± 6 to 63 ± 3 nm), and conversely a reduced hydrodynamic diameter. Conductivity of the dried nanoparticle films was not measureable after a reduction of PVA prior to synthesis. Using filtration of particles after synthesis, PVA content was sufficiently reduced to achieve dried thin film conductivity of 2 S cm -1 , while the electroactivity of the dispersed particles remained unchanged. The as-synthesized and PVA-reduced polypyrrole particles were successfully spun into allnanoparticle fibres using a wet-extrusion approach without the addition of any polymer or gel matrix. Using nanoparticles as a starting material is a novel approach, which allowed the production of macroscale fibres that consisted entirely of polypyrrole nanoparticles. Fibres made from PVA-reduced polypyrrole showed higher electroactivity compared to fibres composed of the dispersion high in PVA. The mechanical properties of the fibres were also improved by reducing the amount of PVA present, resulting in a stronger, more ductile and less brittle fibre, which could find potential application in various fields.

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“…Notably, noble metal NPs impart electrical conductive and catalytic functions useful for enhancing nanomaterial effectiveness (Arvizo et al, 2012). However, conductive properties particular to noble metals in SM scaffolds are rarely applied, though the use of multi-walled CNTs has been successful (Quigley et al, 2012;McKeon-Fischer et al, 2014). Parameter changes in pre-and post-production readily alters physical characteristics, such as size, shape, and composition (Arvizo et al, 2012).…”

Section: Nanoparticle-based Carriers and Active Agents In Regenerationmentioning

confidence: 99%

Nano-Engineered Biomaterials for Tissue Regeneration: What Has Been Achieved So Far?

et al. 2016

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Nanomaterials have attracted the interest of tissue engineers for the last two decades. Their unique properties make them promising for de novo fabrication of bio-inspired hybrid/composite materials with improved regenerative properties, including, for example, the capacity for electric conductivity and the provision of antimicrobial properties. However, to this day, the use of such materials in medical applications is rather limited and most of the studies have only reached the archetypical proof-of-concept stage. Herein, we present a review on the use of nanomaterials in tissue engineering for regenerative therapies of heart, skin, eye, skeletal muscle, and nervous system. The advantages and limitations of nano-engineering materials are presented in this review alongside with the future challenges and milestones nanotechnology must overcome to make an impact in biomedical applications.

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Electrical Stimulation of Myoblast Proliferation and Differentiation on Aligned Nanostructured Conductive Polymer Platforms

Cited by 68 publications

References 47 publications

Progress in Research of Flexible MEMS Microelectrodes for Neural Interface

Progress in Research of Flexible MEMS Microelectrodes for Neural Interface

From nanoparticles to fibres: effect of dispersion composition on fibre properties

Nano-Engineered Biomaterials for Tissue Regeneration: What Has Been Achieved So Far?

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