Bone fracture consolidates faster with low‐power laser

Ma, Tao; Mayayo, Emilio

doi:10.1002/lsm.1900070107

Cited by 232 publications

(132 citation statements)

References 4 publications

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“…For example, a total of 4.0 joules laser energy applied on experimentallyinduced skin incisions [39] or skin defects in rats [30], produces faster collagen synthesis as judged by assaying 14 C glycine and 3H proline or 3H hydroxyproline [30,39]. Similarly, fractures induced in the radii of 44 New Zealand rabbits, irradiated daily with 236 mW cm -2 CO 2 laser for 10 minutes on 10 successive days have been shown to heal faster than controls [40] as do mice tibial fractures irradiated with low intensity He-Ne laser [41].…”

Section: Effects Of Laser Photostimulationmentioning

confidence: 99%

The Biological Effects of Laser Therapy and Other Physical Modalities on Connective Tissue Repair Processes

Enwemeka

Reddy

2000

LASER THERAPY

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Connective tissue injuries, such as tendon rupture and ligamentous strains, are common. Unlike most soft tissues that require 7-10 days to heal, primary healing of tendons and other dense connective tissues take as much as 6 -8 weeks during which they are inevitably protected in immobilization casts to avoid re-injury. Such long periods of immobilization impair functional rehabilitation and predispose a multitude of complications that could be minimized if healing is quickened and the duration of cast immobilization reduced. In separate studies, we tested the hypothesis that early function, ultrasound, 632.8 nm He-Ne laser, and 904 nm Ga-As laser, when used singly or in combination, promote healing of experimentally severed and repaired rabbit Achilles tendons as evidenced by biochemical, biomechanical, and morphological indices of healing. Our results demonstrate that: (1) appropriate doses of each modality, i.e., early functional activities, ultrasound, He-Ne and Ga-As laser therapy augment collagen synthesis, modulate maturation of newly synthesized collagen, and overall, enhance the biomechanical characteristics of the repaired tendons. (2) Combinations of either of the two lasers with early function and either ultrasound or electrical stimulation further promote collagen synthesis when compared to functional activities alone. However, the biomechanical effects measured in tendons receiving the multi-therapy were similar, i.e., not better than the earlier single modality trials. Although tissue repair processes in humans may differ from that of rabbits, these findings suggest that human cases of connective tissue injuries, e.g., Achilles tendon rupture, may benefit from appropriate doses of He-Ne laser, Ga-As laser, and other therapeutic modalities, when used singly or in combination. Our recent meta-analysis of the laser therapy literature further corroborate these findings.

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Section: Effects Of Laser Photostimulationmentioning

confidence: 99%

The Biological Effects of Laser Therapy and Other Physical Modalities on Connective Tissue Repair Processes

Enwemeka

Reddy

2000

LASER THERAPY

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“…Estudos que utilizaram radiação de laser hélio-neô-nio mostraram efeitos benéficos na osteogênese 34,50 com aumento na vascularização e aceleração na razão de formação óssea.…”

Section: Laserunclassified

Tratamentos não farmacológicos na estimulação da osteogênese

et al. 2002

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A carga mecânica provoca microdeformações ósseas, que estimulam células osteoblásticas e, conseqüentemente, promovem adaptações nos ossos, muitas vezes relacionadas com uma menor reabsorção óssea e um aumento na formação óssea local. No entanto, o estímulo para formação óssea depende do número e freqüência das deformações aplicadas no osso. Concomitantemente aos estímulos ósseos providos pelas cargas mecânicas, é importante uma dieta rica em cálcio, a qual também beneficia o aumento da massa óssea. Entretanto, existem também outros métodos não farmacológicos, como o ultra-som pulsado de baixa intensidade, a estimulação elétrica e o laser, que já mostraram efeitos positivos na promoção da osteogênese. Assim, realizou-se um levantamento na literatura, no período de 1982 a 2001, sobre esses métodos não farmacológicos com o objetivo de avaliar tais métodos alternativos, que ajudam no aumento da massa óssea ou no estímulo à osteogênese.

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“…Several reports have shown that low-level laser irradiation (LLLI) stimulates bone regeneration 1,2) . In bone metabolism, in vivo experimental models using biochemical and quantitative histomorphometrical experiments have revealed that LLLI stimulates alkaline phosphatase activity, calcium accumulation and the rapid accumulation of reparative new bone in injuries in rat tibia 3,4) .…”

Section: Introductionmentioning

confidence: 99%

Enhancement of GDP-Dissociation Inhibitor Gene Expression in Osteoblasts by Low-Level Laser Irradiation

Yoshimura

Hayashi

Mizukami

et al. 2011

J. Hard Tissue Biology.

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Low-level laser irradiation (LLLI) stimulates bone regeneration and may be useful for bone fracture and oral implant therapy. However, the molecular mechanism of LLLI in accelerating bone formation is not well known. In order to understand the mechanism of LLLI in accelerating bone formation, we attempted to identify gene expressions enhanced by LLLI by a subtractive gene cloning and DNA microarray analysis. Osteoblastic cell MC3T3-E1 was treated with 830 nm Ga-Al-As diode laser irradiation and total mRNA was recovered and used to construct a subtractive gene library of genes with transcription enhanced by LLLI. The DNA sequences of subtracted gene was subjected to a homology search using BLASTN program in the National Center for Biotechnology Information (NCBI). Genes with mRNA levels altered by LLLI were also analysed using Affymetrix GeneChip. The mRNA levels were confirmed by RT-PCR and real-time PCR. Subtracted gene clones MCL101 indicated high homology with GDP-dissociation inhibitor beta (GDPIB) genes. Affymetrix GeneChip TM analysis was further analyzed and found that GDI alpha gene expression was also enhanced by LLLI. The increased mRNA level of GDIA and GDIB by LLLI was successfully confirmed by RT-PCR and real-time PCR. Since the up-regulation of GDIA is one of the mechanisms underlying the synergistic boneforming effect of parathyroid hormone and oestrogen. Moreover, GDIA and GDIB involve in the regulation of vesicle-mediated cellular transport and anti-apoptosis, the enhancement of GDIA and GDIB gene expressions by LLLI may be a part of mechanisms in the acceleration of bone formation by LLLI.

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Bone fracture consolidates faster with low‐power laser

Cited by 232 publications

References 4 publications

The Biological Effects of Laser Therapy and Other Physical Modalities on Connective Tissue Repair Processes

The Biological Effects of Laser Therapy and Other Physical Modalities on Connective Tissue Repair Processes

Tratamentos não farmacológicos na estimulação da osteogênese

Enhancement of GDP-Dissociation Inhibitor Gene Expression in Osteoblasts by Low-Level Laser Irradiation

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