Bone Graft and Fusion Enhancement

Carlisle, Elliot; Fischgrund, Jeffrey S.

doi:10.1016/b978-141603372-1.50030-5

Cited by 9 publications

(6 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…New studies, however, are examining the potential efficacy of proximal tibial grafts due to lower post-operative pain and similar healing properties to the iliac crest [3,4]. Autografts are resorbable, osteoconductive, osteoinductive, and provide a living source of cells [5]. Donor site morbidity and infection are common concerns regarding autografts [6].…”

Section: Introductionmentioning

confidence: 99%

“…Cadavers lack living osteoblasts and osteoprogenitors, thereby limiting the osteogenic potential of the graft [7,8]. Additionally, allografts are associated with a greater risk of an immune response and graft rejection but have lower donor site morbidity [5]. Apart from autologous or allograft bone transplantations, synthetic or natural polymeric materials may be used in their place.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Bioprinting of Stem Cells in Multimaterial Scaffolds and Their Applications in Bone Tissue Engineering

Tharakan

Khondkar

Ilyas

2021

Sensors

View full text Add to dashboard Cite

Bioprinting stem cells into three-dimensional (3D) scaffolds has emerged as a new avenue for regenerative medicine, bone tissue engineering, and biosensor manufacturing in recent years. Mesenchymal stem cells, such as adipose-derived and bone-marrow-derived stem cells, are capable of multipotent differentiation in a 3D culture. The use of different printing methods results in varying effects on the bioprinted stem cells with the appearance of no general adverse effects. Specifically, extrusion, inkjet, and laser-assisted bioprinting are three methods that impact stem cell viability, proliferation, and differentiation potential. Each printing method confers advantages and disadvantages that directly influence cellular behavior. Additionally, the acquisition of 3D bioprinters has become more prominent with innovative technology and affordability. With accessible technology, custom 3D bioprinters with capabilities to print high-performance bioinks are used for biosensor fabrication. Such 3D printed biosensors are used to control conductivity and electrical transmission in physiological environments. Once printed, the scaffolds containing the aforementioned stem cells have a significant impact on cellular behavior and differentiation. Natural polymer hydrogels and natural composites can impact osteogenic differentiation with some inducing chondrogenesis. Further studies have shown enhanced osteogenesis using cell-laden scaffolds in vivo. Furthermore, selective use of biomaterials can directly influence cell fate and the quantity of osteogenesis. This review evaluates the impact of extrusion, inkjet, and laser-assisted bioprinting on adipose-derived and bone-marrow-derived stem cells along with the effect of incorporating these stem cells into natural and composite biomaterials.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bioprinting of Stem Cells in Multimaterial Scaffolds and Their Applications in Bone Tissue Engineering

Tharakan

Khondkar

Ilyas

2021

Sensors

View full text Add to dashboard Cite

show abstract

“…AG comes in various forms including both cancellous and cortical [ 3 ]. Cancellous AG is most often harvested from the iliac crest (IC); however, other donor sites such as the posterior superior iliac spine, femur, proximal tibia, and distal radius are utilized [ 4 , 5 , 6 , 7 ]. Cancellous AG contains mesenchymal stem cells (MSCs), osteoblasts, and growth factors including bone morphogenetic proteins (BMPs), which contribute to its osteoinductivity [ 3 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…However, cortical AG is less osteoinductive than cancellous AG, and its density results in slower revascularization and inhibits cellular infiltration [ 8 , 9 ]. Despite its osteogenic properties, AG is a scarce resource with multiple drawbacks including donor site morbidity (10–39% of patients), limited availability, the need for a second surgical site [ 6 ], and rapid resorption dependent on the bone density and embryologic origin of the AG [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Settable Polymeric Autograft Extenders in a Rabbit Radius Model of Bone Formation

et al. 2021

View full text Add to dashboard Cite

Autograft (AG) is the gold standard for bone grafts, but limited quantities and patient morbidity are associated with its use. AG extenders have been proposed to minimize the volume of AG while maintaining the osteoinductive properties of the implant. In this study, poly(ester urethane) (PEUR) and poly(thioketal urethane) (PTKUR) AG extenders were implanted in a 20-mm rabbit radius defect model to evaluate new bone formation and graft remodeling. Outcomes including µCT and histomorphometry were measured at 12 weeks and compared to an AG (no polymer) control. AG control examples exhibited new bone formation, but inconsistent healing was observed. The implanted AG control was resorbed by 12 weeks, while AG extenders maintained implanted AG throughout the study. Bone growth from the defect interfaces was observed in both AG extenders, but residual polymer inhibited cellular infiltration and subsequent bone formation within the center of the implant. PEUR-AG extenders degraded more rapidly than PTKUR-AG extenders. These observations demonstrated that AG extenders supported new bone formation and that polymer composition did not have an effect on overall bone formation. Furthermore, the results indicated that early cellular infiltration is necessary for harnessing the osteoinductive capabilities of AG.

show abstract

“…The latter includes tissue damage by disease, trauma or removal by surgery. , Several methods have been developed to treat tissue defects including the use of autografts, allografts and xenografts. Although autografts are traditionally preferred, their retrieval leads to comorbidity of the donor site and the autografts are also short in supply . One of the main issues associated with the use of grafts is the survival of cells after transplantation .…”

Section: Introductionmentioning

confidence: 99%

Advances in Controlled Oxygen Generating Biomaterials for Tissue Engineering and Regenerative Therapy

et al. 2019

View full text Add to dashboard Cite

Oxygen (O 2 ) generating biomaterials are emerging as important compositions to improve our capabilities in supporting tissue engineering and regenerative therapeutics. Several in vitro studies demonstrated the usefulness of O 2 releasing biomaterials in enhancing cell survival and differentiation. However, more efforts are needed to develop materials that can provide sustained O 2 release for the longterm. In this paper, we present different O 2 generating sources, including hydrogen peroxide, sodium percarbonate, calcium peroxide and magnesium peroxide, and also cover types of carriers and relevant methods of fabricating O 2 generating systems. Then, the applications of O 2 generating materials in supporting engineered constructs, supplying high O 2 demanding cell transplants, and supporting ischemic tissues are discussed. Moreover, the challenges and future perspectives are highlighted.

show abstract

Bone Graft and Fusion Enhancement

Cited by 9 publications

References 34 publications

Bioprinting of Stem Cells in Multimaterial Scaffolds and Their Applications in Bone Tissue Engineering

Bioprinting of Stem Cells in Multimaterial Scaffolds and Their Applications in Bone Tissue Engineering

Settable Polymeric Autograft Extenders in a Rabbit Radius Model of Bone Formation

Advances in Controlled Oxygen Generating Biomaterials for Tissue Engineering and Regenerative Therapy

Contact Info

Product

Resources

About