Bone growth and physiologic tooth movement

Sicher, Harry; Weinmann, Joseph P.

doi:10.1016/s0096-6347(44)90257-7

Cited by 84 publications

(46 citation statements)

References 4 publications

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Section: Introductionmentioning

confidence: 94%

“…For the purposes of the current study, physiological root resorption in the rat molar is a useful model because the histological features are similar to the odontoclasts and osteoclasts of human permanent teeth (Sicher and Weinmann, 1944;Hardt, 1988;Nagaoka et al, 2002;Kashiwazaki et al, 2003;Kimura et al, 2003). Since moderate mechanical stress causes a physiological drift of molars in a distal direction with aging (Sicher and Weinmann, 1944;Roberts and Morey, 1985), root resorption possesses spatial and temporal characteristics (Kimura et al, 2003). First, the tartrate-resistant acid phosphate (TRAP)-positive precursor cells for odontoclasts or osteoclasts start appearing in periodontal tissues at 3 weeks of age, and then odontoclasts actively resorb the distal surface on the distal roots of rat maxillary second molars from 4 to 6 weeks of age (Sicher and Weinmann, 1944;Hardt, 1988).…”

Section: Introductionmentioning

confidence: 99%

“…Since moderate mechanical stress causes a physiological drift of molars in a distal direction with aging (Sicher and Weinmann, 1944;Roberts and Morey, 1985), root resorption possesses spatial and temporal characteristics (Kimura et al, 2003). First, the tartrate-resistant acid phosphate (TRAP)-positive precursor cells for odontoclasts or osteoclasts start appearing in periodontal tissues at 3 weeks of age, and then odontoclasts actively resorb the distal surface on the distal roots of rat maxillary second molars from 4 to 6 weeks of age (Sicher and Weinmann, 1944;Hardt, 1988). After the decrease followed by the peak of root resorption at 5 weeks, newly formed resorption lacunae on the distal roots of second molars are mostly undetectable by 8 weeks even though the osteoclasts keep resorbing the alveolar bone facing the distal roots of the second molar (Nagaoka et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

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Comparison of expression patterns of cathepsin K and MMP-9 in odontoclasts and osteoclasts in physiological root resorption in the rat molar

Tsuchiya

Akiba

Takahashi

et al. 2008

Arch. Histol. Cytol.

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Summary. Root resorption lacunae are principally formed by odontoclasts. While these cells develop from the same origin as osteoclasts, odontoclasts normally have fewer nuclei and a less clear zone compared with osteoclasts. We therefore, hypothesized that odontoclasts possess less differentiation in matrix resorption characteristics than osteoclasts. To test our hypothesis, we compared the TRAP-positive area and the expression patterns of two important proteolytic enzymes, cathepsin K and matrix metalloproteinase-9 (MMP-9), between odontoclasts and osteoclasts. We focused on physiological root resorption in the rat molar, which is a useful experimental model for estimating odontoclasts and osteoclasts. Observations showed the number of nuclei and the TRAP-positive area of odontoclasts to be significantly less compared with osteoclasts. Using in situ hybridization and double labeling fluorescence in situ hybridization showed the majority of odontoclasts to express both cathepsin K and MMP-9, especially 4 and 5 weeks of age, when physiological root resorption occurs actively. Moreover, putative precursor cells of odontoclasts, which typically appeared in the middle of the periodontal ligament at 3 weeks of age, expressed both enzymes. In contrast, the majority of matured osteoclasts expressed only cathepsin K but not MMP-9. We suggest that odontoclasts are comparable to osteoclasts with less differentiation with regard to the expression of proteolytic enzymes.

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Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Comparison of expression patterns of cathepsin K and MMP-9 in odontoclasts and osteoclasts in physiological root resorption in the rat molar

Tsuchiya

Akiba

Takahashi

et al. 2008

Arch. Histol. Cytol.

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“…The continuous growth of rat jaws by posterior lengthening is thought to initiate these movements (Sicher and Weinmann, 1944). When teeth migrate, the bone surrounding them must be remodeled ahead of the migrating root.…”

Section: Discussionmentioning

confidence: 99%

Comparative35S-sulfate and3H-proline metabolism within the interdental septal bone and adjacent periodontal ligament

Johnson

2006

Anat. Rec.

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Tooth movements require rapid remodeling of the periodontal ligament (PDL) and adjacent alveolar bone. Our objective was to compare the regional metabolism of sulfated-glycosaminoglycans (sGAG) within the PDL and adjacent alveolar bone and compare it to the metabolism of collagenous proteins using radioautographic techniques. Rats were injected with either 3 H-proline or 35 S-sulfate and maxillae were removed at 1, 6, and 12 hr 1-7 days later. Silver grains were counted over the PDL and adjacent alveolar bone and the incorporation and removal rates for each radioisotope were determined. In general, net collagenous protein incorporation and removal were greatest within the distal and net sGAG incorporation and removal were greatest within the mesial compartments of the periodontium. The rate of removal of 3 H-proline was significantly greater within the distal alveolar bone surface than the adjacent PDL at all levels (P Ͻ 0.001). In contrast, the rate of removal of 35 S-sulfate was significantly greater in the PDL than within the adjacent mesial surface of the interdental septum at all levels (P Ͻ 0.001). The mesial surfaces of the interdental septum had a slower rate of removal of both isotopes than distal surfaces at all levels (P Ͻ 0.001). Our data suggest significant regional differences in the metabolism of 35 S-sulfate and 3 H-proline within the PDL and alveolar bone, which likely result from the characteristics of the forces produced by the adjacent teeth and may be a factor in the remodeling of the alveolar wall coincident to tooth movement. Key words: alveolar bone; periodontal ligament; glycosaminoglycans; physiological tooth movement; collagenous proteinsThe periodontal ligament (PDL) anchors the root of the tooth to the adjacent alveolar bone and also separates the tooth root from the alveolar wall. The structural components of the PDL include a fibrous component, providing structural support for the teeth, and noncollagenous matrix interspersed between the collagen fibers, which is composed of proteoglycans and glycoproteins (Embery et al., 1995). The fibrous component resists tension forces from adjacent tooth roots and the noncollagenous matrix portion resists the compression forces by forming a biphasic medium with water, giving viscoelastic properties to the PDL (Mow et al., 1984). While there are significant regional differences in the metabolism of collagenous proteins within the PDL, there is little information about the regional metabolism of PDL proteoglycans and glycosaminoglycans. Accurate knowledge of this regional variability

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“…He asserted that the resorbed area of the root will be repaired by secondary cementum and that the necrotic area of the periodontal membrane will heal. Sicher and Weinmann (1944) found that the constant presence of a superficial layer of uncalcified cementoid tissue renders the tooth relati vely immune to resorption. Therefore, the pressure caused by the apposition of bone on one alveolar wall is transmitted by the moving tooth to the opposite alveolar wall where it causes resorption.…”

Section: Chapter II Review Of the Literature Part Imentioning

confidence: 99%

An investigation of the deposition of alveolar bone in the orthodontic tipping of teeth in monkeys

Martuccio¹

1969

American Journal of Orthodontics

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Bone growth and physiologic tooth movement

Cited by 84 publications

References 4 publications

Comparison of expression patterns of cathepsin K and MMP-9 in odontoclasts and osteoclasts in physiological root resorption in the rat molar

Comparison of expression patterns of cathepsin K and MMP-9 in odontoclasts and osteoclasts in physiological root resorption in the rat molar

Comparative35S-sulfate and3H-proline metabolism within the interdental septal bone and adjacent periodontal ligament

An investigation of the deposition of alveolar bone in the orthodontic tipping of teeth in monkeys

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