2008
DOI: 10.1679/aohc.71.89
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Comparison of expression patterns of cathepsin K and MMP-9 in odontoclasts and osteoclasts in physiological root resorption in the rat molar

Abstract: Summary. Root resorption lacunae are principally formed by odontoclasts. While these cells develop from the same origin as osteoclasts, odontoclasts normally have fewer nuclei and a less clear zone compared with osteoclasts. We therefore, hypothesized that odontoclasts possess less differentiation in matrix resorption characteristics than osteoclasts. To test our hypothesis, we compared the TRAP-positive area and the expression patterns of two important proteolytic enzymes, cathepsin K and matrix metalloprotei… Show more

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Cited by 16 publications
(13 citation statements)
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“…Although no difference has ever been recognized between odontoclasts and osteoclasts in structural and histochemical properties, these two cells work at different places (odontoclasts work in dental hard tissues, while osteoclasts work in bone). Similar results were obtained in further studies in rats and cows (Linsuwanont et al, 2002;Tsuchiya et al, 2008).…”
Section: Ctsk and Tooth Root Resorptionsupporting
confidence: 90%
“…Although no difference has ever been recognized between odontoclasts and osteoclasts in structural and histochemical properties, these two cells work at different places (odontoclasts work in dental hard tissues, while osteoclasts work in bone). Similar results were obtained in further studies in rats and cows (Linsuwanont et al, 2002;Tsuchiya et al, 2008).…”
Section: Ctsk and Tooth Root Resorptionsupporting
confidence: 90%
“…In the T group, new cementum was observed as deposition on the resorption lacunae in part of the root dentin. Because odontoclasts have expression patterns of cathepsin K and matrix metalloproteinase-9 (MMP-9) similar to osteoclasts, the odontoclasts could have been stimulated by the active bone formation and high bone turnover 39) . Götz et al reported that cementoblasts were involved in the resorption-repair sequence, which is considered to be a coupling process as in bone 40) .…”
Section: Discussionmentioning
confidence: 99%
“…Like osteoclasts, odontoclasts are multinucleated giant TRAP-positive cells with ruffled borders [88]. Tsuchiya et al reported that odontoclasts had fewer nuclei, smaller TRAP-positive area, and higher expression of MMP-9 than osteoclasts [89]. It remains unclear whether odontoclasts and osteoclasts can be considered functionally identical.…”
Section: Root Resorptionmentioning
confidence: 99%