Bone healing in critical‐size defects treated with bioactive glass/calcium sulfate: a histologic and histometric study in rat calvaria

Abstract

BG particles, used with or without a CS barrier, maintained the volume and contour of the area grafted in CSD. However, they did not lead to a significant difference in bone formation when compared with control at 12 weeks post-operative.

Evaluation of the ability of collagen–glycosaminoglycan scaffolds with or without mesenchymal stem cells to heal bone defects in Wistar rats

“…This demonstrated that 5-mm calvarial defect was of a critical size (non healing within the length of the study). This is in line with the results of several previous studies [20][21][22][23]. The bone healing in the test groups was found to be significantly higher than the bone healing achieved by the empty defect group (P<0.0001).…”

Cellularized versus decellularized scaffolds for bone regeneration

“…All cell-seeded scaffolds were maintained in a humidified incubator, at 37C and 5% CO 2, with medium changes every 3 days for 21 days prior implantation. According to previous studies, 5 mm calvarial defect is considered a critical-sized, non-healing defect along the length of the study [21,22].…”

Small intestine submucosa sponge for in vivo support of tissue-engineered bone formation in the presence of rat bone marrow stem cells

“…Despite the good results obtained using SIS, few studies have evaluated the SIS sponge as a scaffold for repairing shaped bones. Several groups reported that stem cells or cytokines treated scaffolds exhibited complete healing of 5 mm bone defect of rat crania by as early as 4 weeks [36][37][38][39][40][41]. Accordingly, we used a surgical bone-defect model (5 mm) to easily assess the potential of the SIS sponge to act as a scaffold in the repair of damaged bone.…”