Bone Healing in the Presence of a Biodegradable PBS-DLA Copolyester and Its Composite Containing Hydroxyapatite

Abstract

The healing process of the fractured bone in a presence of poly(butylene succinate-butylene dilinoleate) (PBS-DLA) copolymer containing nanosized hydroxyapatite (HAP) particles has been investigated. The PBS-DLA material containing PBS hard segments and DLA soft segments (50:50 wt %) was used to prepare a polymer/ceramic composite with 30 wt % HAP. A new PBS-DLA copolymer showed a high elasticity of 500% and 15 MPa tensile strength. Addition of HAP improved tensile strength up to 25 MPa while high elasticity has been preserved going down only to 300% of elongation at break. A polymer nanocomposite was fabricated into small elastic polymer rods 15 mm long and 1 × 2 mm in cross section and used for tibia bone fixation in rats. Mallory trichrome staining indicated that new biodegradable copolymers and its composite containing HAP have triggered the most advanced bone healing of all tested materials, thus indicating their high potential for bone tissue engineering and repair.

Synthesis of Hydrophilic Poly(butylene succinate-butylene dilinoleate) (PBS-DLS) Copolymers Containing Poly(Ethylene Glycol) (PEG) of Variable Molecular Weights

“…Another great advantage is their use in medical applications, including tissue engineering in soft and hard tissue repair, drug delivery systems and resorbable sutures [ 3 , 4 , 5 , 6 ]. While the majority of research in recent decades has been focused on poly(lactic acid)/polylactide (PLA) and its copolymers, increasing interest is being directed towards another aliphatic polyester, poly(butylene succinate) (PBS), characterized by interesting physical and biological properties [ 7 ]. First of all, it is derived from succinic acid (SA), either derived from biomass or as endogen metabolite monomer, imparting biodegradability and high biocompatibility to PBS.…”

Functionalized Porous Hydroxyapatite Scaffolds for Tissue Engineering Applications: A Focused Review

“…The doping of TiO 2 improves mechanical strength and inhibits the growth size of grains of HAP. The material has comparatively better density and also tolerates loads and, hence, can be used to replace fractured bones in clinical trials . One interesting fact is HAP can also exhibit UV protection properties when HAP is substituted with iron.…”

“…Herein, 30 wt % HAP with poly­(butylene succinate) (PBS) as the hard part and DLA (dimer linoleic acid) acting as the soft part for nanocomposites show excellent tensile strength with higher elasticity. The PBS-DLA nanocomposite enhances biodegradability, and HAP material promotes the bone healing process, which makes the scaffold a potential material in bone fixation application …”

“…The material has comparatively better density and also tolerates loads and, hence, can be used to replace fractured bones in clinical trials. 48 One interesting fact is HAP can also exhibit UV protection properties when HAP is substituted with iron. Studies revealed that ferric chloride (FeCl 2 ) in basic pH is a much better inclusion.…”

“…The PBS-DLA nanocomposite enhances biodegradability, and HAP material promotes the bone healing process, which makes the scaffold a potential material in bone fixation application. 48 Other work discloses integrated n-TiO 2 HAP/PEEK nanocomposites and demonstrates good flexural strength and bioactivity. n-TiO 2 inserted HAP/PEEK nanocomposite provides more contact area and excellent mechanical properties.…”