Bone Health Status among Postmenopausal Women in Malaysia

Nurumal, Mohd. Said; Isa, Muhammad Lokman; Hatta, Nik Noor Kaussar Nik Mohd; Daud, Azlina; Ibrahim, Muhammad; Sharifudin, Mohd Ariff; Deraman, Samsul

doi:10.15296/ijwhr.2019.28

Cited by 3 publications

(2 citation statements)

References 21 publications

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“…A T-score is evaluated based on a comparison of an individual's BMD with the average BMD of normal young population of the same gender [103]. Osteoporosis primarily affects women, especially postmenopausal, due to decreased estrogen hormone levels [104]. Estrogen plays a vital role in bone remodeling by contributing to the formation of bone-forming cells.…”

Section: Osteoporosismentioning

confidence: 99%

Astaxanthin as a Potent Antioxidant for Promoting Bone Health: An Up-to-Date Review

Davan,

Fakurazi,

Alias

et al. 2023

Antioxidants

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In recent years, bone loss and its associated diseases have become a significant public health concern due to increased disability, morbidity, and mortality. Oxidative stress and bone loss are correlated, where oxidative stress suppresses osteoblast activity, resulting in compromised homeostasis between bone formation and resorption. This event causes upregulation of bone remodeling turnover rate with an increased risk of fractures and bone loss. Therefore, supplementation of antioxidants can be proposed to reduce oxidative stress, facilitate the bone remodeling process, suppress the initiation of bone diseases, and improve bone health. Astaxanthin (3,3′-dihydroxy-4-4′-diketo-β-β carotene), a potent antioxidant belonging to the xanthophylls family, is a potential ROS scavenger and could be a promising therapeutic nutraceutical possessing various pharmacological properties. In bone, astaxanthin enhances osteoblast differentiation, osteocytes numbers, and/or differentiation, inhibits osteoclast differentiation, cartilage degradation markers, and increases bone mineral density, expression of osteogenic markers, while reducing bone loss. In this review, we presented the up-to-date findings of the potential anabolic effects of astaxanthin on bone health in vitro, animal, and human studies by providing comprehensive evidence for its future clinical application, especially in treating bone diseases.

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Section: Osteoporosismentioning

confidence: 99%

Astaxanthin as a Potent Antioxidant for Promoting Bone Health: An Up-to-Date Review

Davan,

Fakurazi,

Alias

et al. 2023

Antioxidants

View full text Add to dashboard Cite

show abstract

“…In Malaysia, published journal articles on bone health are still scarce among the children population. Researches on the bone health have primarily focused on Malaysian postmenopausal women [ 14 ] and adult populations [ 15 ]. Moreover, no published research has investigated the relationship between bone health and body composition in Malaysian children.…”

Section: Introductionmentioning

confidence: 99%

Bone Health and Its Positive Relationships with Body Composition in Malaysian Schoolchildren: Findings from a Cross-Sectional Study

et al. 2021

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Background: Optimal bone health is vital in children to prevent osteoporosis later in life, and body composition plays a crucial role in it. However, the literature reports contradictory results when considering the relationship between body composition and bone health in children. This study aimed to examine the bone health and its relationship with body composition in Malaysian schoolchildren. Methods: In this cross sectional study, body composition data (weight, height, body fat percentage [% fat], fat mass, fat free mass, visceral fat, waist circumference [WC] and body mass index-for-age [BMI z-score]) and bone health data (Z-score and broadband ultrasound attenuation [BUA]) were collected from 415 schoolchildren aged 9–12 years, cluster sampled from randomly selected primary schools in Kuala Lumpur, Malaysia. Results: Girls generally had significantly higher height, body fat percentage, fat mass, visceral fat and Z-score as compared to boys. A steady increase of the mean BUA value was observed with increasing age in both sexes. The mean BUA value of the present study across the population was significantly higher than that of schoolchildren from Nigeria (p < 0.001), Colombia (p < 0.001) and Spain (p = 0.002). Significant positive correlations were found between all the body composition variables and bone outcome variables across the population. Further, BUA was significantly correlated with weight (β = 0.172; p = 0.001), height (β = 0.299; p < 0.001), % fat (β = 0.131; p = 0.007), fat mass (β = 0.130; p = 0.007), fat free mass (β = 0.209; p < 0.001), visceral fat (β = 0.127, p = 0.008), WC (β = 0.165; p = 0.001) and BMI z-score (β = 0.162; p = 0.001), after controlling for sex, age and ethnicity. Similarly, after confounders adjusted, Z-score was significantly predicted by weight (β = 0.160; p = 0.001), height (β = 0.310; p < 0.001), % fat (β = 0.104; p = 0.032), fat mass (β = 0.107; p = 0.026), fat free mass (β = 0.218; p < 0.001), visceral fat (β = 0.107, p = 0.026), WC (β = 0.145; p = 0.002) and BMI z-score (β = 0.150; p = 0.002). Conclusions: Our findings have revealed that body composition variables were positive correlated with bone outcome variables, suggesting that adipose tissue acts to stimulate bone growth. Further clinical and molecular studies in the future is recommended to fully illustrate the complex interactions between adiposity and bone health.

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The Role of Parathyroid Hormone in Alveolar Bone Resorption on Postmenopausal Women

Puspitadewi¹,

Kusdhany²,

Masulili³

et al. 2020

TODENTJ

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Background: Postmenopausal women exhibit reduced bone mineralization, which causes bone resorption, including that of alveolar bone. Parathyroid hormone has been shown to play a role in alveolar bone resorption. Objective: This study aims to analyze relationships between parathyroid hormone and other factors that may contribute to alveolar bone resorption in postmenopausal women. Methods: This cross-sectional study included 82 postmenopausal women aged 50–74 years, who resided in Central and East Jakarta, Indonesia. Subjects' data were obtained through questionnaires, dental examinations, and blood collection for the examination of parathyroid hormone levels by enzyme-linked immunosorbent assay and using panoramic radiography to measure bone resorption. Results: Spearman correlation analysis showed a significant correlation between parathyroid hormone level (p = 0.005) and extent of alveolar bone resorption, but age (p = 0.292), menopausal duration (p = 0.244), and number of missing teeth (p = 0.517) were not significantly correlated with the extent of alveolar bone resorption. Conclusion: Various factors play a role in the mechanism of bone resorption, so knowing the role of each factor is expected to reduce the effects of alveolar bone resorption that occurs in postmenopause. Among the factors investigated in this study, the parathyroid hormone was the sole factor correlated with postmenopausal alveolar bone resorption.

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Bone Health Status among Postmenopausal Women in Malaysia

Cited by 3 publications

References 21 publications

Astaxanthin as a Potent Antioxidant for Promoting Bone Health: An Up-to-Date Review

Astaxanthin as a Potent Antioxidant for Promoting Bone Health: An Up-to-Date Review

Bone Health and Its Positive Relationships with Body Composition in Malaysian Schoolchildren: Findings from a Cross-Sectional Study

The Role of Parathyroid Hormone in Alveolar Bone Resorption on Postmenopausal Women

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