Bone ingrowth and stress shielding with a porous surface coated fracture fixation plate

Pilliar, R. M.; Cameron, Hugh U.; Binnington, A. G.; Szivek, John A.; Macnab, Ian

doi:10.1002/jbm.820130510

Cited by 118 publications

(50 citation statements)

References 8 publications

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“…A possible explanation for this observation could be the increased stress-shielding occurring at the implant-tissue interface in response to WBV. These stress concentrations may have evoked increased bone resorption at the implant neck [49]. Noteworthy mentioning and in agreement with the findings of a μCT imaging study assessing the bone micro-architecture in se relative to the hormonal and mechanical status [25], the association of pharmacological (ALN) with mechanical treatment (HF WBV) did not lead to a synergistic reaction influencing the bone healing response at any level (cortical/medullar) or region (implant surface, implant interfacial, and remote zone).…”

Section: Discussionmentioning

confidence: 99%

High-frequency loading positively impacts titanium implant osseointegration in impaired bone

et al. 2014

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Summary High-frequency loading via whole body vibration promotes bone formation and increases bone strength. Whether this translates to positive titanium implant osseointegration in osteoporotic bone was explored in this animal study. An anabolic effect of not only bisphosphonate treatment but also high-frequency loading on implant osseointegration in osteoporotic bone was observed. Introduction The present study investigated the impact of high-frequency (HF) loading, applied via whole body vibration (WBV), on titanium implant osseointegration in healthy versus ovariectomyinduced compromised versus pharmacologically treated compromised bone. Methods A custom-made Ti implant was inserted into the metaphyseal tibia of 59 rats and left to heal for either 4 or 14 days. Rats were divided into six groups according to their hormonal and mechanical status. WBV, consisting of 10 consecutive frequency steps at an acceleration of 0.3g, was applied daily for either 4 or 14 days. Tissue samples were processed for quantitative histology at the tibial cortical and medullar level. Data were analyzed by three-way ANOVA and by post hoc pairwise comparisons. Results The bone healing response at the interface and surrounding titanium implants was negatively influenced by osteoporotic bone conditions, mainly at the trabecular bone level. Furthermore, the administration of bisphosphonates for preventing the ovariectomy-induced impaired periimplant response was successful. Finally, the effect of HF WBV loading on the peri-implant bone healing was dependent on the bone condition and was anabolic solely in untreated osteoporotic trabecular bone when applied for an extended period of time. ConclusionsThe bone healing response to implant installation is compromised in osteoporotic bone conditions, in particular at the trabecular bone compartment. Meanwhile, not only pharmacological treatment but also mechanical loading via HF WBV can exert a positive effect on implant osseointegration in this specific bone micro-environment. The peri-implant cortical bone, however, seems to be less sensitive to HF WBV loading influences.

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Section: Discussionmentioning

confidence: 99%

High-frequency loading positively impacts titanium implant osseointegration in impaired bone

et al. 2014

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“…Another consideration is the modulus of elasticity mismatch between α + β Ti alloys, which is approximately between 110 GPa and 115 GPa, and cortical bone, which is approximately 30 GPa [11,30]. The stiffer implant carries the load rather than the bone, which atrophies and loses density (osteopenia) due to lack of functional stimulation in a process known as stress shielding [77]. This process may in turn lead to fractures or loosening of the implant.…”

Section: Biomedical Implantsmentioning

confidence: 99%

A Review of Metastable Beta Titanium Alloys

Kolli

Devaraj

2018

Metals

493

175

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Abstract:In this article, we provide a broad and extensive review of beta titanium alloys. Beta titanium alloys are an important class of alloys that have found use in demanding applications such as aircraft structures and engines, and orthopedic and orthodontic implants. Their high strength, good corrosion resistance, excellent biocompatibility, and ease of fabrication provide significant advantages compared to other high performance alloys. The body-centered cubic (bcc) β-phase is metastable at temperatures below the beta transus temperature, providing these alloys with a wide range of microstructures and mechanical properties through processing and heat treatment. One attribute important for biomedical applications is the ability to adjust the modulus of elasticity through alloying and altering phase volume fractions. Furthermore, since these alloys are metastable, they experience stress-induced transformations in response to deformation. The attributes of these alloys make them the subject of many recent studies. In addition, researchers are pursuing development of new metastable and near-beta Ti alloys for advanced applications. In this article, we review several important topics of these alloys including phase stability, development history, thermo-mechanical processing and heat treatment, and stress-induced transformations. In addition, we address recent developments in new alloys, phase stability, superelasticity, and additive manufacturing.

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“…The Young s modulus of Ti-64 ELI, although lower than those of steels and Co-Cr-Mo alloys 1) , is 110 GPa; that of cortical human bone is only 10-30 GPa 9) . Such a mismatch can cause stress shielding effects 10) , which prevent loads that are essential for the health of the bone tissue, leading to bone resorption and a decrease in the quality of the bone around the implant 3,11) . In recent years, increased efforts have been directed at producing more biocompatible Ti alloys 2) .…”

Section: Introductionmentioning

confidence: 99%

Effects of Mo Addition on the Mechanical Properties and Microstructures of Ti-Mn Alloys Fabricated by Metal Injection Molding for Biomedical Applications

et al. 2017

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Ti-Mn alloys fabricated by metal injection molding (MIM) show promising performance for biomedical applications, but their low ductility (caused by high O content and the presence of pores and carbides) requires improvement. Previously, the addition of Mo to cold crucible levitation melted (CCLM) Ti-Mn alloys ef ciently improved the ductility of those alloys by promoting mechanical twinning. In the present study, Mo was added to Ti-Mn alloys fabricated by MIM. Unlike fabrication by CCLM, fabrication by MIM can produce alloys with a smaller grain size, and also introduce microstructures such as pores and Ti carbides. Thus, in order to investigate how Mo addition interacts with these typical MIM features, four alloys for biomedical applications were fabricated by MIM: Ti-5Mn-3Mo (TMM-53), Ti-5Mn-4Mo (TMM-54), Ti6Mn-3Mo (TMM-63), and Ti-6Mn-4Mo (TMM-64). Their microstructures, mechanical properties, and tensile deformation mechanisms were evaluated. Their hardness values range from 312-359 HV, and their Young s modulus values range from 84-88 GPa; both the Vickers hardness and Young s modulus show little variation among the alloys. Although the alloys show fracture features associated with a predominantly ductile fracture mode and Mo addition successfully promotes mechanical twinning in TMM-54, the elongation of these alloys is still critically low. Compared to the TMM alloys fabricated by CCLM, the TMM alloys fabricated by MIM show slightly lower hardness and Young s modulus, and comparable tensile strength, with their low elongation remaining inadequate for such applications. In particular, TMM-63 shows the best combination of mechanical properties among the present alloys, with an elongation of 4% and an ultimate tensile strength of 1145 MPa.

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Bone ingrowth and stress shielding with a porous surface coated fracture fixation plate

Cited by 118 publications

References 8 publications

High-frequency loading positively impacts titanium implant osseointegration in impaired bone

High-frequency loading positively impacts titanium implant osseointegration in impaired bone

A Review of Metastable Beta Titanium Alloys

Effects of Mo Addition on the Mechanical Properties and Microstructures of Ti-Mn Alloys Fabricated by Metal Injection Molding for Biomedical Applications

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