Bone Invasion by Squamous Cell Carcinoma In Situ (Bowen's Disease) of the Finger During Treatment With Imiquimod 5% Cream: Case Report

Gong, Hyun Sik; Cho, Jae Hwan; Roh, Young Hak; Chung, Moon Sang; Baek, Goo Hyun

doi:10.1016/j.jhsa.2010.02.027

Cited by 9 publications

(8 citation statements)

References 30 publications

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“…The safest treatment is micrographic surgery, but many less invasive and non-surgical treatments such as laser ablation, cryotherapy, photodynamic therapy, topical 5-fluorouracil and topical imiquimod have been used in selected cases [4,29,30,31]. However, given the risk of recurrence and in favour of our observation that koilocytes indicative of persistent HPV infection might remain at the margins in micrographic surgery (fig.…”

Section: Discussionmentioning

confidence: 91%

“…Chronic traumatization, exposure to arsenic or ultraviolet and ionizing radiation have been discussed. In addition, HPV infections are thought to be a causative factor [3,4]. To follow this line, we studied biopsy specimens of 3 patients with BD of the nail apparatus for the presence of HPV DNA and reviewed 74 cases reported in the literature.…”

Section: Introductionmentioning

confidence: 99%

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High-Risk Human Papillomavirus Infection in Bowen’s Disease of the Nail Unit: Report of Three Cases and Review of the Literature

et al. 2011

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Background: Bowen’s disease (BD) of the nail unit is associated with human papillomavirus (HPV) infection. Objective: This study aimed to investigate the frequency of high-risk HPV infection, gender, age and digital distribution in this condition. Methods: Biopsy specimens of 3 consecutive cases with periungual BD were investigated for the presence of HPV DNA by in situ hybridization and by polymerase chain reaction (PCR). Furthermore, 74 cases of ungual BD conducted with HPV genotyping as reported in the literature were reviewed. Results: PCR of biopsy specimens revealed in 2 cases infection with HPV-16 and in 1 case with HPV-73. Additionally, in 1 HPV-16-positive case HPV-31/33 was detected by in situ hybridization. In line, review of the literature demonstrated a clear association of HPV-positive BD with high-risk HPV types. Interestingly, age at diagnosis was significantly lower in women. Whereas in both genders the second to fourth fingers on both hands were commonly diseased, only in men the thumbs were also prominently affected. Conclusions: Infection with high-risk HPV types is common in BD of the nail unit suggesting the aetiological cause. Therefore, patients and partners should be closely followed up for digital and genital HPV-associated lesions.

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Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

High-Risk Human Papillomavirus Infection in Bowen’s Disease of the Nail Unit: Report of Three Cases and Review of the Literature

et al. 2011

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“…[6] As far as ascertained, there is a single report of Bowen's disease in English literature of an eczematous plaque involving distal digit. [7] Secondly, the location of the lesion over the finger was also atypical. The common sites for Bowen's disease include the chronically photo-exposed sites like head and neck and dorsae of hands and lower legs.…”

Section: Discussionmentioning

confidence: 99%

“…But none of these studies give any details about digital lesions. Although anecdotal reports of Bowen's disease occurring over digits have been described, [7,[11][12][13] it still remains a rare site.…”

Section: Discussionmentioning

confidence: 99%

“…The current literature supports our approach of surgery as there are 3 reports/series on failure of imiquimod for cutaneous Bowen's. Gong et al [7] described a case of eczematous plaque over distal part of finger (histologically Bowen's) which resolved initially with sixteen week imiquimod therapy only to recur after 2 months when the same regimen was repeated. But the lesion was nonresponsive the second time and was invading the underlying bone, thus prompting ray amputation of the finger.…”

Section: Discussionmentioning

confidence: 99%

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Bowen′s disease on finger: A diagnostic and therapeutic challenge

Singh

Khaitan

Sharma

et al. 2013

Indian J Dermatol Venereol Leprol

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Bowen's disease commonly presents as a solitary asymptomatic plaque involving head and neck region or lower limbs. We present a case of a sixty seven-year-old man with an itchy, oozy, crusted solitary plaque on the right ring finger of eighteen months duration with histopathology consistent with Bowen's disease. The lesion was initially treated with topical 5% imiquimod but due to relapse and inadequate response to a second course, complete surgical excision followed by full thickness skin grafting was done. Recurrence after about 6 months in the form of a small papule adjacent to the initial site was also treated with excision. This report highlights the potential of Bowen's disease to mimic more common dermatoses and a high index of suspicion, supported by histopathology, is required to diagnose and treat it without delay, which in turn may require a multimodality approach. We also reviewed the current literature on the same.

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Immunocryosurgery for Nonmelanoma Skin Cancer: Applications and Practical Tips

Gaitanis

Bassukas

2014

Cryosurgery

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Bone Invasion by Squamous Cell Carcinoma In Situ (Bowen's Disease) of the Finger During Treatment With Imiquimod 5% Cream: Case Report

Cited by 9 publications

References 30 publications

High-Risk Human Papillomavirus Infection in Bowen’s Disease of the Nail Unit: Report of Three Cases and Review of the Literature

High-Risk Human Papillomavirus Infection in Bowen’s Disease of the Nail Unit: Report of Three Cases and Review of the Literature

Bowen′s disease on finger: A diagnostic and therapeutic challenge

Immunocryosurgery for Nonmelanoma Skin Cancer: Applications and Practical Tips

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