Bone-Like Apatite Formation on Modified PCL Surfaces under Different Conditions

Wang, Ying Jun; Yang, Chun Rong; Zheng, Hua De; Chen, Xiaofeng; Ning, Cheng Yun; Ren, Li; Deng, Chun Lin

doi:10.4028/www.scientific.net/kem.330-332.671

Cited by 6 publications

(3 citation statements)

References 11 publications

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“…A study proposed the NaOH etching to modify the PCL surface for an apatite layer deposit. The reported apatite formation indicated that NaOH hydrolysis induced a dense and uniform apatite layer formation due to the introduced carboxylate groups on the PCL surfaces . Another report has shown that the concentration of NaOH, the reaction temperature, and the treatment time influence the porosity and the roughness of 3D-printed PCL surfaces.…”

Section: Introductionmentioning

confidence: 98%

“…The reported apatite formation indicated that NaOH hydrolysis induced a dense and uniform apatite layer formation due to the introduced carboxylate groups on the PCL surfaces. 21 Another report has shown that the concentration of NaOH, the reaction temperature, and the treatment time influence the porosity and the roughness of 3D-printed PCL surfaces. Hence, the proliferation of cells increased with increasing the surface roughness and porosity, whereas the scaffold’s mechanical strength decreased.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Pore Characteristics and Alkali Treatment on the Physicochemical and Biological Properties of a 3D-Printed Polycaprolactone Bone Scaffold

et al. 2023

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Polycaprolactone scaffolds were designed and 3D-printed with different pore shapes (cube and triangle) and sizes (500 and 700 μm) and modified with alkaline hydrolysis of different ratios (1, 3, and 5 M). In total, 16 designs were evaluated for their physical, mechanical, and biological properties. The present study mainly focused on the pore size, porosity, pore shapes, surface modification, biomineralization, mechanical properties, and biological characteristics that might influence bone ingrowth in 3D-printed biodegradable scaffolds. The results showed that the surface roughness in treated scaffolds increased compared to untreated polycaprolactone scaffolds (R a = 2.3−10.5 nm and R q = 17− 76 nm), but the structural integrity declined with an increase in the NaOH concentration especially in the scaffolds with small pores and a triangle shape. Overall, the treated polycaprolactone scaffolds particularly with the triangle shape and smaller pore size provided superior performance in mechanical strength similar to that of cancellous bone. Additionally, the in vitro study showed that cell viability increased in the polycaprolactone scaffolds with cubic pore shapes and small pore sizes, whereas mineralization was enhanced in the designs with larger pore sizes. Based on the results obtained, this study demonstrated that the 3D-printed modified polycaprolactone scaffolds exhibit a favorable mechanical property, biomineralization, and better biological properties; therefore, they can be applied in bone tissue engineering.

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Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Effect of Pore Characteristics and Alkali Treatment on the Physicochemical and Biological Properties of a 3D-Printed Polycaprolactone Bone Scaffold

et al. 2023

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“…Polyvinylpyrolidone (PVP) is the amphiphilic polymer, which has a series of advantages such as excellent solubility, complexation ability and biocompatibility, and some results about synthesis of nanoparticles using PVP as a template and dispersants have been reported in reference [8][9][10][11]. Hydroxyapatite synthesized in syntetic body fluids was more similar to nature bone [12][13][14]. To synthesize biomimetic hydroxyapatite and avoid of agglomeration without toxic surfactant, this study synthesizes HAP in SBF using PVP as a template and dispersants, and rheological properties and the effects of HAP sol modified by PVP were analyzed.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Biomimetic Hydroxyapatite in Syntetic Body Fluids

Yin

Ning

Zhu³

et al. 2008

KEM

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In this study, biomemitic hydroxyapatite was prepared as a nano-sized powder from calcium nitrate tetrahydrate and diammonium hydrogen phosphate salts, but using the different contents of PVP modified hydroxyapatite and synthetic body fluid (SBF) solutions as synthesis medium instead of pure water at 37.4C and pH of 7.4. SBF was prepared in accord with the chemical analysis of human body fluid, with ion concentrations nearly equal to those of the inorganic constituents of human blood plasma. Characterization and chemical analaysis of the synthesized biomemitic hydroxyapatite powders and pure hydroxyapatite were investigated by X-ray powder diffraction, scanning electron microscopy, and inductively coupled plasma atomic emission spectroscopy. Rheological properties of HAP sol which reflected the interaction of hydroxyapatite particles were measured by R/S rheometer. The results showed that PVP evidently affected the stability and rheological properties of HAP sol, and PVP were based on the different mechanism at different concentrations. PVP was operating as an interparticle bridging reagent at low concentrations(0.5%), while it acted as an dispersant at high concentrations(2.0%). The biomemitic hydroxyapatite with the sizes of 10~30nm was spherical and poor crystalline, which was synthesized in synthetic body fluid (SBF) by addition of 2.0% PVP.

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Layer‐by‐layer assembly of antibacterial coating on interbonded 3D fibrous scaffolds and its cytocompatibility assessment

Tang

Zhao

Wang

et al. 2012

J Biomedical Materials Res

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Bonded fibrous matrices have shown great potential in tissue engineering because of their unique 3D structures and pore characteristics. For some applications, bacterial infections must be taken into account, and antibacterial function is highly desired. In this study, an antibacterial polymer, polyhexamethylene biguanide (PHMB), was applied onto the fiber surface of a bonded poly(ε-caprolactone) (PCL) fibrous matrix with the objective to achieve both strong antibacterial effect and good cell compatibility. The coatings were prepared by using an electrostatic layer-by-layer (LbL) assembly technique, which allowed the control of PHMB loading and coating uniformity on the fiber surface. The PHMB coating provided antibacterial activities, but had no toxicity on mammalian cells. This bonded PCL fibrous matrix with electrostatically self-assembled PHMB may provide a new antiinfective tissue scaffold for various biomedical applications.

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Bone-Like Apatite Formation on Modified PCL Surfaces under Different Conditions

Cited by 6 publications

References 11 publications

Effect of Pore Characteristics and Alkali Treatment on the Physicochemical and Biological Properties of a 3D-Printed Polycaprolactone Bone Scaffold

Effect of Pore Characteristics and Alkali Treatment on the Physicochemical and Biological Properties of a 3D-Printed Polycaprolactone Bone Scaffold

Synthesis of Biomimetic Hydroxyapatite in Syntetic Body Fluids

Layer‐by‐layer assembly of antibacterial coating on interbonded 3D fibrous scaffolds and its cytocompatibility assessment

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