Bone Marrow Adipose Tissue: Regulation of Osteoblastic Niche, Hematopoiesis and Hematological Malignancies

Labella, Rossella; Vujacic, Marko; Trivanović, Drenka

doi:10.1007/s12015-023-10531-3

Cited by 9 publications

(6 citation statements)

References 104 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…BM adipocytes secrete fatty acids, adipokines, cytokines, and EVs, with a great influence over the distinct BM niches [reviewed in [197,198]]. Although the role of BM adipocytes in regulating/inhibiting haematopoiesis is still controversial [199,200], they seem to be able to boost haematopoiesis under stressful conditions through the secretion of SCF at similar levels to their BMMSC precursors [191].…”

Section: Endothelial Cells and Progenitorsmentioning

confidence: 99%

Transforming the Niche: The Emerging Role of Extracellular Vesicles in Acute Myeloid Leukaemia Progression

Mendes,

Monteiro,

Neto

et al. 2024

IJMS

View full text Add to dashboard Cite

Acute myeloid leukaemia (AML) management remains a significant challenge in oncology due to its low survival rates and high post-treatment relapse rates, mainly attributed to treatment-resistant leukaemic stem cells (LSCs) residing in bone marrow (BM) niches. This review offers an in-depth analysis of AML progression, highlighting the pivotal role of extracellular vesicles (EVs) in the dynamic remodelling of BM niche intercellular communication. We explore recent advancements elucidating the mechanisms through which EVs facilitate complex crosstalk, effectively promoting AML hallmarks and drug resistance. Adopting a temporal view, we chart the evolving landscape of EV-mediated interactions within the AML niche, underscoring the transformative potential of these insights for therapeutic intervention. Furthermore, the review discusses the emerging understanding of endothelial cell subsets’ impact across BM niches in shaping AML disease progression, adding another layer of complexity to the disease progression and treatment resistance. We highlight the potential of cutting-edge methodologies, such as organ-on-chip (OoC) and single-EV analysis technologies, to provide unprecedented insights into AML–niche interactions in a human setting. Leveraging accumulated insights into AML EV signalling to reconfigure BM niches and pioneer novel approaches to decipher the EV signalling networks that fuel AML within the human context could revolutionise the development of niche-targeted therapy for leukaemia eradication.

show abstract

Section: Endothelial Cells and Progenitorsmentioning

confidence: 99%

Transforming the Niche: The Emerging Role of Extracellular Vesicles in Acute Myeloid Leukaemia Progression

Mendes,

Monteiro,

Neto

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

“…Recent studies have identified novel subsets of BMA progenitor cells that are recruited to various skeletal and hematopoietic stem cell niches during BM adipogenesis [51]. Longterm hematopoiesis is also regulated by the spatial distribution of BMAs.…”

Section: Humoral Factors Affecting Adipogenesis and Myelopoiesismentioning

confidence: 99%

“…Longterm hematopoiesis is also regulated by the spatial distribution of BMAs. It has been found that the lipolytic and secretory activity of BMAs can influence the survival and proliferation of hematopoietic cells at different stages of maturation [51].…”

Section: Humoral Factors Affecting Adipogenesis and Myelopoiesismentioning

confidence: 99%

Adipocyte- and Monocyte-Mediated Vicious Circle of Inflammation and Obesity (Review of Cellular and Molecular Mechanisms)

Todosenko,

Khaziakhmatova,

Malashchenko

et al. 2023

IJMS

View full text Add to dashboard Cite

Monocytes play a key role in the development of metabolic syndrome, and especially obesity. Given the complex features of their development from progenitor cells, whose regulation is mediated by their interactions with bone marrow adipocytes, the importance of a detailed study of the heterogeneous composition of monocytes at the molecular and systemic levels becomes clear. Research argues for monocytes as indicators of changes in the body’s metabolism and the possibility of developing therapeutic strategies to combat obesity and components of metabolic syndrome based on manipulations of the monocyte compound of the immune response. An in-depth study of the heterogeneity of bone-marrow-derived monocytes and adipocytes could provide answers to many questions about the pathogenesis of obesity and reveal their therapeutic potential.

show abstract

“…[45][46][47] The role of BM adipocytes in hematopoiesis regulation is complex and still under investigation. 48 Adipocytes secrete fatty acids, hormones, adipokines, and cytokines, which have profound effects on the function of other neighboring cell populations in the BM microenvironment. Although previous studies identified BM adipocytes as negative regulators of hematopoiesis, 49 recent works have revealed that they positively regulate HSC regeneration under stress conditions.…”

Section: The Role Of Mscs and Their Progeny In The Regulation Of Norm...mentioning

confidence: 99%

“…The role of BM adipocytes in hematopoiesis regulation is complex and still under investigation 48 . Adipocytes secrete fatty acids, hormones, adipokines, and cytokines, which have profound effects on the function of other neighboring cell populations in the BM microenvironment.…”

Section: The Role Of Mscs and Their Progeny In The Regulation Of Norm...mentioning

confidence: 99%

A Question of Frame: The Role of the Bone Marrow Stromal Niche in Myeloid Malignancies

Tomasoni¹,

Pievani²,

Rambaldi

et al. 2023

HemaSphere

View full text Add to dashboard Cite

Until a few years ago, the onset of acute myeloid leukemia (AML) was entirely ascribed to genetic lesions in hematopoietic stem cells. These mutations generate leukemic stem cells, which are known to be the main ones responsible for chemoresistance and relapse. However, in the last years, increasing evidence demonstrated that dynamic interplay between leukemic cells and bone marrow (BM) niche is of paramount relevance in the pathogenesis of myeloid malignancies, including AML. Specifically, BM stromal niche components, such as mesenchymal stromal cells (MSCs) and their osteoblastic cell derivatives, play a key role not only in supporting normal hematopoiesis but also in the manifestation and progression of myeloid malignancies. Here, we reviewed recent clinical and experimental findings about how genetic and functional alterations in MSCs and osteolineage progeny can contribute to leukemogenesis and how leukemic cells in turn generate a corrupted niche able to support myeloid neoplasms. Moreover, we discussed how the newest single-cell technologies may help dissect the interactions between BM stromal cells and malignant hematopoiesis. The deep comprehension of the tangled relationship between stroma and AML blasts and their modulation during disease progression may have a valuable impact on the development of new microenvironment-directed therapeutic strategies, potentially useful for a wide cohort of patients.

show abstract

Bone Marrow Adipose Tissue: Regulation of Osteoblastic Niche, Hematopoiesis and Hematological Malignancies

Cited by 9 publications

References 104 publications

Transforming the Niche: The Emerging Role of Extracellular Vesicles in Acute Myeloid Leukaemia Progression

Transforming the Niche: The Emerging Role of Extracellular Vesicles in Acute Myeloid Leukaemia Progression

Adipocyte- and Monocyte-Mediated Vicious Circle of Inflammation and Obesity (Review of Cellular and Molecular Mechanisms)

A Question of Frame: The Role of the Bone Marrow Stromal Niche in Myeloid Malignancies

Contact Info

Product

Resources

About