Bone marrow capacity for bone cells and trabecular bone turnover in immobilized tibia after sciatic neurectomy in mice

Sakai, Akinori; Nakamura, Toshio; Tsurukami, Hiroshi; Okazaki, Ryo; Nishida, Satoshi; Tanaka, Yuri; Norimura, Toshiyuki; Suzuki, K.

doi:10.1016/8756-3282(96)00042-7

Cited by 53 publications

(48 citation statements)

References 25 publications

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“…Unloading by hindlimb immobilization due to neurectomy also induces bone loss (Turner & Bell 1986, Wakley et al 1988. This reduction in bone mass is caused by an initial decrease in bone formation and subsequent increase in the osteoclastic bone resorption (Weinreb et al 1989, Murakami et al 1994, Zeng et al 1996, Sakai et al 1996, Shen et al 1997. Neurectomy decreases the parameters of endosteal bone formation in the tibiae of mice with a subsequent increase or no increase in the eroded surface or the size of medullary cavity at 4 weeks after surgery (Kodama et al 1999).…”

Section: Introductionmentioning

confidence: 99%

Klotho-deficient mice are resistant to bone loss induced by unloading due to sciatic neurectomy

Yamashita¹,

Sekiya²,

Kawaguchi³

et al. 2001

Journal of Endocrinology

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Unloading induces bone loss as seen in experimental animals as well as in space flight or in bed-ridden conditions; however, the mechanisms involved in this phenomenon are not fully understood. Klotho mutant mice exhibit osteopetrosis in the metaphyseal regions indicating that the klotho gene product is involved in the regulation of bone metabolism. To examine whether the klotho gene product is involved in the unloading-induced bone loss, the response of the osteopetrotic cancellous bones in these mice was investigated. Sciatic nerve resection was conducted using klotho mutant (kl/kl) and control heterozygous mice (+/kl) and its effect on bone was examined by micro-computed tomography ( CT). As reported previously for wild-type mice (+/+), about 30% bone loss was induced in heterozygous mice (+/kl) by unloading due to neurectomy within 30 days of the surgery. By contrast, kl/kl mice were resistant against bone loss induced by unloading after neurectomy. Unloading due to neurectomy also induced a small but significant bone loss in the cortical bone of the mid-shaft of the femur in the heterozygous mice; no reduction in the cortical bone was observed in kl/kl mice. These results indicate that klotho mutant mice are resistant against bone loss induced by unloading due to neurectomy in both cortical and trabecular bone and indicate that klotho is one of the molecules involved in the loss of bone by unloading.

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Section: Introductionmentioning

confidence: 99%

Klotho-deficient mice are resistant to bone loss induced by unloading due to sciatic neurectomy

Yamashita¹,

Sekiya²,

Kawaguchi³

et al. 2001

Journal of Endocrinology

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“…It was reported that the non-load condition of space flight, and immobilization with sciatic nerve excision, cause a decrease in bone mass, but don't disturb longitudinal normal growth of the tibia in growing rats 31,32) . We investigated the effects of immobilization on hind limb structures in the growth period, using growing rats as subjects.…”

Section: Effects Of Mechanical Stress On Bone Structuresmentioning

confidence: 99%

“…It is reported that the effects of a reduction in mechanical stress on cancellous bone appears at an earlier period [1][2][3] . It is shown that the bone trabeculae that disappeared by short-term immobilization don't recover to a normal state by the mechanical loading for the identified period as that immobilization period [32][33][34] .…”

Section: Effects Of Mechanical Stress On Bone Structuresmentioning

confidence: 99%

Characteristics of bone structural changes by growth and mechanical stress in growing rats

Ohsako

Morita

Inoue

et al. 2014

JPFSM

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Cortical bone is porous in infants but compacts with growth. In that process, circumferential lamellae are formed on the endosteum (inner) side of cortical bone first, and also the periosteum (exterior) side, after that. A mature rat shows higher bone strength per unit area of the cortical bone, and this means that not only an increase in the bone mass, but also improvement of the bone structure contributes to enhancing the bone strength. External morphology of the bone hardly changes by immobilization, but the thickness of the cortical bone decreases, and disorder of the running direction of the blood vessels in the cortical bone also occurs. Bone formation and resorption are caused simultaneously at the early stage of an exercise period, and it is supposed that factors embedded in the bone matrix beforehand are released into bone marrow by exercise, differentiating and activating the osteoblasts. Thus, it is thought that bone adapted to mechanical stress is formed by repeating active remodeling in the growing period.

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“…I mmobilisation of limbs induces local bone loss in humans 1 and animals. 2 Immobilised experimental animals simulate conditions of disuse of bones, such as paralysis, plaster cast application, and long term bed rest. It has been shown that bone loss in paraplegic patients 1 and sciatic neurectomised mice 2 is due to increased bone resorption as well as reduced bone formation.…”

mentioning

confidence: 99%

“…Bone formation decreased 7-14 days after immobilisation. 2 The underlying mechanism(s) of rapid reduction of bone formation after limb immobilisation has not been elucidated.…”

mentioning

confidence: 99%

Trabecular bone mass and bone formation are preserved after limb immobilisation in p53 null mice

Okazaki

Sakai²,

Ootsuyama³

et al. 2004

Annals of the Rheumatic Diseases

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Bone marrow capacity for bone cells and trabecular bone turnover in immobilized tibia after sciatic neurectomy in mice

Cited by 53 publications

References 25 publications

Klotho-deficient mice are resistant to bone loss induced by unloading due to sciatic neurectomy

Klotho-deficient mice are resistant to bone loss induced by unloading due to sciatic neurectomy

Characteristics of bone structural changes by growth and mechanical stress in growing rats

Trabecular bone mass and bone formation are preserved after limb immobilisation in p53 null mice

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