2017
DOI: 10.1016/j.yexcr.2017.07.014
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Bone marrow-derived mesenchymal stem cells propagate immunosuppressive/anti-inflammatory macrophages in cell-to-cell contact-independent and -dependent manners under hypoxic culture

Abstract: Immunosuppressive/anti-inflammatory macrophage (Mφ), M2-Mφ that expressed the typical M2-Mφs marker, CD206, and anti-inflammatory cytokine, interleukin (IL)-10, is beneficial and expected tool for the cytotherapy against inflammatory diseases. Here, we demonstrated that bone marrow-derived lineage-positive (Lin+) blood cells proliferated and differentiated into M2-Mφs by cooperation with the bone marrow-derived mesenchymal stem cells (MSCs) under hypoxic condition: MSCs not only promoted proliferation of undif… Show more

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Cited by 55 publications
(53 citation statements)
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“…In the context of stem cell-based therapies, preclinical studies in myocardial infarction have demonstrated the immunomodulatory capacity of MSCs promoting the shift from M1 to M2 macrophages (Cho et al, 2014). More recently, a deep analysis of MSCsmacrophages interactions have shown that MSCs triggered the proliferation/differentiation of macrophages toward M2 by cellto-cell contact, and by soluble factors where CSF-1 has a key role (Takizawa et al, 2017). All these findings, together with the identification of CSF-1 in these vesicles, and its significant increase in EVs from IFNγ-primed cells, may suggest that EV-endMSCs promote a M2 polarization.…”
Section: Discussionmentioning
confidence: 99%
“…In the context of stem cell-based therapies, preclinical studies in myocardial infarction have demonstrated the immunomodulatory capacity of MSCs promoting the shift from M1 to M2 macrophages (Cho et al, 2014). More recently, a deep analysis of MSCsmacrophages interactions have shown that MSCs triggered the proliferation/differentiation of macrophages toward M2 by cellto-cell contact, and by soluble factors where CSF-1 has a key role (Takizawa et al, 2017). All these findings, together with the identification of CSF-1 in these vesicles, and its significant increase in EVs from IFNγ-primed cells, may suggest that EV-endMSCs promote a M2 polarization.…”
Section: Discussionmentioning
confidence: 99%
“…We hypothesise that whilst the effectiveness of these treatment methodologies is similar in potency, the underlying mechanisms of action differ. Interestingly, MSCs under hypoxic culture have been shown to promote anti-in ammatory M2 macrophage polarization through a mechanism also dependent upon ICAM-1 adhesion(79), although hypoxic MSCs exhibit reduced reactive oxygen species (ROS) levels and increased resistance to ROS stress and upregulate secretion of growth factors and cytokines such as TGF-β, IL-8, IL-10 and PGE2, which are also implicated in macrophage polarisation and MSC immunomodulatory capacity (36,79,80).…”
Section: Discussionmentioning
confidence: 99%
“…The in vivo study involved the use of a DEN-induced liver brosis/cirrhotic murine model. The successful isolation of donor cells was performed using a novel "Percoll-Plate-Wait" protocol [6] for MLpvNG2 + cells and a classical protocol for niBM-MSCs [31] .…”
Section: Discussionmentioning
confidence: 99%