Bone Marrow Involvement in a Patient with Paracoccidioidomycosis: A Rare Presentation of Juvenile Form

Pereira, Graziella Hanna; Santos, Aline Queiroz; Park, Miriam; Müller, Patrícia Rady; Padua, Soraia; Marchesi, Raquel Ferrari; Aldred, Vera Lucia

doi:10.1007/s11046-010-9314-5

Cited by 7 publications

(5 citation statements)

References 6 publications

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“…Osteoarticular PCM is also rarely described. The few studies addressing this report the bone infection occurring frequently in children or younger adults, in the acute/subacute phase of the disease [28][29][30][31][32][33]. Most of the described cases come from Brazil.…”

Section: Discussionmentioning

confidence: 99%

Osteomyelitis and Aortic Arteritis with thrombosis as primary manifestations of systemic paracoccidioidomycosis: a case report

Duarte-Neto,

Dantas,

Lombardi

et al. 2024

Preprint

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Background Paracoccidioidomycosis (PCM) is a neglected deep mycosis caused by Paracoccidioides sp. We describe a fatal PCM case, presenting as osteomyelitis, in a man having frequent contact with an endemic region of São Paulo, Brazil. Case presentation: A 67-year-old man who lived in an urban area, had frequent fishing trips to an endemic region. He presented with osteomyelitis of the femur and iliac artery thrombosis at hospital admission. Thoracic CT revealed multiple cavitated lung nodules. The patient rapidly progressed to irreversible respiratory failure. The autopsy revealed disseminated PCM and thrombosis of the iliac artery. Laboratory investigation confirmed a P. brasiliensis infection with phylogenetic results revealing sequences recovered from patient samples grouped with sequences characterized as P. brasiliensis complex. Conclusion Atypical PCM remains a diagnostic challenge. Increased awareness of contagion sites and different clinical presentations will lead to improved patient management.

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Section: Discussionmentioning

confidence: 99%

Osteomyelitis and Aortic Arteritis with thrombosis as primary manifestations of systemic paracoccidioidomycosis: a case report

Duarte-Neto,

Dantas,

Lombardi

et al. 2024

Preprint

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“…Acute/ subacute paracoccidioidomycosis, juvenile type, classically occurs in young patients of both sexes and is characterized by tropism of the fungus to the monocyte-phagocyte system. 1 - 4 …”

Section: Discussionmentioning

confidence: 99%

Paracoccidioidomycosis: acute-subacute clinical form, juvenile type

Marques

Lastória

Camargo

et al. 2016

An. Bras. Dermatol.

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The authors report aspects of paracoccidioidomycosis, acute-subacute clinical form, juvenile type, in a 19-year-old female patient. Paracoccidioidomycosis, juvenile type, classically occurs in young patients, both sexes, with lymphoma-like aspects as initial presentation. However, following the natural history of the disease the lymph nodes assume patterns of infectious disease, as an abscess and fistulae. Systemic dissemination of the disease can occur and lethality and morbidity are significant in this clinical presentation.

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“…In adult patients, hypertrophied lymph nodes may also be detected albeit not as frequently as in the juvenile form; they are located preferentially in the neck region; if in the abdomen, enlarged nodes may coalesce forming large masses that simulate a tumor [1-4, 5•, 78-80]. Adrenal gland involvement is also a classic sign with Addison syndrome being detected in ≥ 10 % of patients; at autopsy, a much higher (85 %) number reveal adrenal gland involvement [79,86,87].…”

Section: Clinical Manifestationsmentioning

confidence: 99%