Bone Marrow Macrophages

Hudson, G.; Shortland, J. R.

doi:10.1007/978-1-4899-5031-4_8

Cited by 9 publications

(7 citation statements)

References 80 publications

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“…The distribution of F4/80 in bone-marrow ( Fig. 1) accords well with identification of macrophages based on ultrastructural or cytochemical criteria (16)(17)(18)(19)(20). Their role in erythropoiesis, erythrophagocytosis, and iron metabolism in this site has been described (20, review).…”

Section: Discussionsupporting

confidence: 77%

“…One obvious candidate is the Ia + "interdigitating cell" that has been described in thymus and in T cell-dependent areas of lymphoid organs (10-15). However, whilst the isolated splenic dendritic cell has virtually none of the functional characteristics of a mononuclear phagocyte (6), it has been suggested that interdigitating cells are members of the mononuclear phagocyte system and are related to epidermal Langerhans cells and similar cells .found in afferent lymphatics (14).Apart from T cell activation during an immune response, macrophages have also been implicated in the control of hematopoiesis in the bone marrow (16)(17)(18)(19)(20), the differentiation of thymocytes in the thymus (21),. proliferation and keratinization of squamous epithelial cells (Langerhans cells [22][23][24]), and the antibody response of B lymphocytes to T-independent antigens (25).In order to determine the roles of mononuclear phagocytes and other cells in these systems, it is necessary to have reliable surface markers analogous to those that have delineated subclasses of T lymphocytes (26).…”

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confidence: 99%

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The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80. Relationship between macrophages, Langerhans cells, reticular cells, and dendritic cells in lymphoid and hematopoietic organs.

Hume¹,

Robinson²,

MacPherson³

et al. 1983

The Journal of Experimental Medicine

352

133

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The immune response genes of the major histocompatibility gene complex code for surface antigens (Ia) now believed to be involved in the interaction between T cells and accessory or "antigen-presenting" cells (1, 2). Whilst some groups suggest that Ia antigens present on subpopulations of mononuclear phagocytes are involved in T cell activation (1-4), others have presented evidence for the involvement of a separate Ia + cell population (5-8) now generally referred to as dendritic cells. The in vivo correlate of the isolated antigen-presenting dendritic cell is not yet clear. The availability of a specific monoclonal antibody against mouse dendritic cells (9) will be helpful in clarifying this question. One obvious candidate is the Ia + "interdigitating cell" that has been described in thymus and in T cell-dependent areas of lymphoid organs (10-15). However, whilst the isolated splenic dendritic cell has virtually none of the functional characteristics of a mononuclear phagocyte (6), it has been suggested that interdigitating cells are members of the mononuclear phagocyte system and are related to epidermal Langerhans cells and similar cells .found in afferent lymphatics (14).Apart from T cell activation during an immune response, macrophages have also been implicated in the control of hematopoiesis in the bone marrow (16)(17)(18)(19)(20), the differentiation of thymocytes in the thymus (21),. proliferation and keratinization of squamous epithelial cells (Langerhans cells [22][23][24]), and the antibody response of B lymphocytes to T-independent antigens (25).In order to determine the roles of mononuclear phagocytes and other cells in these systems, it is necessary to have reliable surface markers analogous to those that have delineated subclasses of T lymphocytes (26). F4/80 is a hybridoma that secretes a noncytotoxic rat IgG2b directed against a 160-kdalton plasma membrane antigen of mouse mononuclear phagocytes (27).

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Section: Discussionsupporting

confidence: 77%

mentioning

confidence: 99%

The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80. Relationship between macrophages, Langerhans cells, reticular cells, and dendritic cells in lymphoid and hematopoietic organs.

Hume¹,

Robinson²,

MacPherson³

et al. 1983

The Journal of Experimental Medicine

352

133

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“…Figure 6 shows a carbon-laden astrocyte in direct contact with a macrophage loaded with carbon particles; however, a reverse pathway may also be possible. Hudson and Shortland (1980) proposed that a similar mechanism exists between macrophages and bone marrow cells. The third possibility is that carbon-laden astrocytes lyse in situ and are subsequently removed by macrophages.…”

Section: Discussionmentioning

confidence: 99%

Ultrastructural study of phagocytic activities of young astrocytes in injured neonatal rat brain following intracerebral injection of colloidal carbon

Al-Ali

Al-Zuhair

Dawod

1988

Glia

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The cellular reaction to injury in the mature central nervous system (CNS) has been extensively studied in both man and animals, while a detailed study of the reaction of the immature CNS to injury is lacking in the literature. This study was undertaken to elucidate the response of young astrocytes following injection injury to developing brain. Colloidal carbon was applied because it is a suitable marker for phagocytosis, it is nontoxic, and it is readily identifiable by light and electron microscopy. The cerebral cortex of the neonatal rat was injected with 0.1 microliter of colloidal carbon solution. The animals were allowed to survive from 1 hour to 30 days postoperation. The brains were fixed by vascular perfusion and processed for light and electron microscopy. Carbon particles were ingested in membrane-bound vacuoles and sequestered in lysosomes of young astrocytes. Astrocytes, loaded with carbon particles, were identified after 4 days, and were seen in abundance between 10 to 21 days postoperation. Carbon-laden astrocytes were seen in the immediate vicinity of the site of the injection; in the surrounding, apparently normal, neuropil; and in the perivascular regions. This study demonstrates the ability of young astrocytes to engulf foreign particles injected into the developing brain. The presence of carbon particles in astrocytes located further away from the site of injection is discussed.

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“…There are a few reports on mammalian bone marrow which suggest that at least some macrophages may migrate either from marrow to blood or vice versa (HUDSON and SHORTLAND, 1980). It may be possible to show a different mode of macrophage-migration in chick marrow, because the avian marrow shows a unique structure in which erythrocytopoiesis occurs only within the sinus, which is not the case in mammalian bone S sinus.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, the bone marrow origin of mammalian macrophages has been confirmed ( VAN FURTH et al, 1972), but it remains to be investigated whether avian marrow macrophages are derived from there or other reticuloendothelial organs. It is well known that macrophages ingest old red blood cells or colloidal iron to provide iron to erythroblasts, and in consequence form erythroblastic islands in mammalian bone marrow (BESSIS and BRETON-GORIUS, 1962;GERMAN, 1967;FEDORKO et al, 1973;HUDSON and SHORTLAND, 1980). Should they do the same in chick marrows, ironladen macrophages might stay in the sinus without migration, because erythrocytopoiesis occurs only within the sinus in chick bone marrow.…”

Section: Discussionmentioning

confidence: 99%