Bone marrow mesenchymal stem cell’s exosomes as key nanoparticles in osteogenesis and bone regeneration: specific capacity based on cell type

Farashah, Mohammad Sadegh Gholami; Javadi, Maryam; Mohammadi, Amir Hossein; Rad, Jafar Soleimani; Shakouri, Seyed Kazem; Roshangar, Leila

doi:10.1007/s11033-022-07807-1

Cited by 13 publications

(13 citation statements)

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“…3D, the mRNA expression levels of osteogenesis-related genes were higher in BMSCs cultivated on Gel-BP and Gel-BP-Exo than in cells cultured on Gel, and there were significant differences in the mRNA expression levels of ALP , RUNX2 , COL1A1 , and OPN . The results not only substantiated the previous findings that BP and BMSC-derived exosomes could induce the osteogenic differentiation of stem cells 7,41,54 but also demonstrated that Gel-BP-Exo can increase the osteogenic differentiation of BMSCs in a synergistic manner. BMSC-exosomes may not only contain osteogenic stimulatory factors, such as RUNX2, COL1A1, OPN, and ALP, but they may also further stimulate osteogenic differentiation by acting on BMSCs to produce the related factors.…”

Section: Resultssupporting

confidence: 88%

Section: Biocompatibility Of Exosome-loaded Black Phosphorus Thermose...supporting

confidence: 89%

“…On the one hand, exosomes encouraged cellular adherence through a series of surface attachment proteins and carrier ligands; on the other hand, BMSC-derived exosomes containing BMSC membrane components might boost BMSC adhesion. 41…”

Section: Resultsmentioning

confidence: 99%

“…38,39 In exosomes derived from BMSCs, some miRNAs have also been found to regulate osteoblast differentiation and promote bone tissue regeneration. 7,40,41 Therefore, we extracted the rat BMSC-derived exosomes for the subsequent experiments.…”

Section: Characterization and Identification Of Exosomesmentioning

confidence: 99%

“…On the one hand, exosomes encouraged cellular adherence through a series of surface attachment proteins and This journal is © The Royal Society of Chemistry 2023 carrier ligands; on the other hand, BMSC-derived exosomes containing BMSC membrane components might boost BMSC adhesion. 41 ALP activity assay and expression levels of osteogenesis-related genes ALP is frequently considered an early indication of osteogenic development. New bone formation and extracellular calcium deposition are indicated by the increased production of ALP during osteogenic differentiation.…”

Section: Biocompatibility Of Exosome-loaded Black Phosphorus Thermose...mentioning

confidence: 99%

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Black phosphorus thermosensitive hydrogels loaded with bone marrow mesenchymal stem cell-derived exosomes synergistically promote bone tissue defect repair

Hua

Peng

et al. 2023

J. Mater. Chem. B

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Section: Resultssupporting

confidence: 88%

Section: Biocompatibility Of Exosome-loaded Black Phosphorus Thermose...supporting

confidence: 89%

Section: Resultsmentioning

confidence: 99%

Section: Characterization and Identification Of Exosomesmentioning

confidence: 99%

Section: Biocompatibility Of Exosome-loaded Black Phosphorus Thermose...mentioning

confidence: 99%

See 3 more Smart Citations

Black phosphorus thermosensitive hydrogels loaded with bone marrow mesenchymal stem cell-derived exosomes synergistically promote bone tissue defect repair

Hua

Peng

et al. 2023

J. Mater. Chem. B

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Polycaprolactone/Testicular Extracellular Matrix/Graphene Oxide‐Based Electrospun Tubular Scaffolds for Reproductive Medicine: Biomimetic Architecture of Seminiferous Tubules

Mohammadi,

Koruji,

Azami

et al. 2023

Macromolecular Bioscience

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Numerous diverse scaffolds have been developed in the field of testicular bioengineering. However, effectively replicating the spatial characteristics of native tissue, poses a challenge in maintaining the requisite cellular arrangement essential for proper spermatogenesis. In order to mimic the structural properties of seminiferous tubules, our objective was to fabricate a biocompatible tubular scaffold. Following the decellularization process of the testicular tissue, validation of cellular remnants' elimination from the specimens was conducted using DAPI staining, H&E staining, and DNA content analysis. The presence of extracellular matrix components was confirmed through Alcian blue, Orcein, and Masson's trichrome staining techniques. The electrospinning technique was employed to synthesize the scaffolds using polycaprolactone, extracted ECM, and varying concentrations of graphene oxide (0.5%, 1%, and 2%). Subsequently, comprehensive evaluations were performed to assess the properties of the synthetic scaffolds. These evaluations encompassed Fourier‐transform infrared spectroscopy, scanning electron microscopy imaging, scaffold degradation testing, mechanical behavior analysis, MTT assay, and in vivo biocompatibility assessment. The PCL/dECM with 0.5% GO formulation exhibited superior fiber morphology, enhanced mechanical properties, and outperformed other groups in terms of in vitro biocompatibility. Consequently, these scaffolds present a viable option for implementation in “in vitro spermatogenesis” procedures, holding promise for future sperm production from spermatogonial cells.This article is protected by copyright. All rights reserved

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Bone marrow mesenchymal stem cells’ osteogenic potential: superiority or non-superiority to other sources of mesenchymal stem cells?

et al. 2023

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Bone marrow mesenchymal stem cell’s exosomes as key nanoparticles in osteogenesis and bone regeneration: specific capacity based on cell type

Cited by 13 publications

References 131 publications

Black phosphorus thermosensitive hydrogels loaded with bone marrow mesenchymal stem cell-derived exosomes synergistically promote bone tissue defect repair

Black phosphorus thermosensitive hydrogels loaded with bone marrow mesenchymal stem cell-derived exosomes synergistically promote bone tissue defect repair

Polycaprolactone/Testicular Extracellular Matrix/Graphene Oxide‐Based Electrospun Tubular Scaffolds for Reproductive Medicine: Biomimetic Architecture of Seminiferous Tubules

Bone marrow mesenchymal stem cells’ osteogenic potential: superiority or non-superiority to other sources of mesenchymal stem cells?

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