Bone Marrow Mononuclear Cell Transplantation Restores Inflammatory Balance of Cytokines after ST Segment Elevation Myocardial Infarction

Abstract

BackgroundAcute myocardial infarction (AMI) launches an inflammatory response and a repair process to compensate cardiac function. During this process, the balance between proinflammatory and anti-inflammatory cytokines is important for optimal cardiac repair. Stem cell transplantation after AMI improves tissue repair and increases the ventricular ejection fraction. Here, we studied in detail the acute effect of bone marrow mononuclear cell (BMMNC) transplantation on proinflammatory and anti-inflammatory cytokines in patients with ST segment elevation myocardial infarction (STEMI).MethodsPatients with STEMI treated with thrombolysis followed by percutaneous coronary intervention (PCI) were randomly assigned to receive either BMMNC or saline as an intracoronary injection. Cardiac function was evaluated by left ventricle angiogram during the PCI and again after 6 months. The concentrations of 27 cytokines were measured from plasma samples up to 4 days after the PCI and the intracoronary injection.ResultsTwenty-six patients (control group, n = 12; BMMNC group, n = 14) from the previously reported FINCELL study (n = 80) were included to this study. At day 2, the change in the proinflammatory cytokines correlated with the change in the anti-inflammatory cytokines in both groups (Kendall’s tau, control 0.6; BMMNC 0.7). At day 4, the correlation had completely disappeared in the control group but was preserved in the BMMNC group (Kendall’s tau, control 0.3; BMMNC 0.7).ConclusionsBMMNC transplantation is associated with preserved balance between pro- and anti-inflammatory cytokines after STEMI in PCI-treated patients. This may partly explain the favorable effect of stem cell transplantation after AMI.

Preventive effect of hesperidin modulates inflammatory responses and antioxidant status following acute myocardial infarction through the expression of PPAR‑γ and Bcl‑2 in model mice

“…AMI is a pathological process accompanied by an inflammatory response. Inflammatory cytokines are important in ventricular remodeling following myocardial infarction (5). At the early stage of infarction, the local inflammatory reaction is prominent and, with high levels of inflammatory cell infiltration, inflammatory cells and inflammatory cytokine can adversely affect cell-transplant therapy (6).…”

Autologous bone marrow mononuclear cell transplantation therapy improved symptoms in patients with refractory diabetic peripheral neuropathy via the mechanisms of paracrine and immunomodulation

“…But in a study including Stsegment Elevation Myocardial Infarction (STEMI) patients, BM-MNCs transplantation was performed via an intracoronary route. Their results indicated that BM-MNCs transplantation after STEMI affects the balance between proinflammatory and anti-inflammatory cytokines [27]. Additional studies are required to fully understand the immunomodulation effects of BM-MNCs transplantation in treating DPN.…”

Cell therapy in the multimodality treatment of a patient with dilated cardiomyopathy. A case report

“…Как механизм действия АМФКМ у пациентов с ХСН обсуждается: улучшение процессов кровоснабжения миокарда за счет процессов васкулогенеза, ангиогенеза и артериогенеза [26][27][28][29]; уменьшение апоптотической гибели кардиомиоцитов [26][27][28][29][30]; уменьшение репаративного и реактивного фиброза в миокарде [27][28][29]; регенерация сердца с появлением новых кардиомиоцитов, эндотелиальных и гладкомышечных клеток [27-29, 31, 32], иммуномодулирующее действие [33][34][35]. Эти положительные изменения в сердце могут быть связаны как непосредственно с участием клеток мононуклеарной фракции в этих процессах, так и с выделением ими различных цитокинов, факторов роста и сигнальных молекул (паракринное действие).…”