Bone mass development is sensitive to insulin resistance in adolescent boys

Rønne, Maria Sode; Heidemann, Malene; Lylloff, Louise; Schou, Anders; Tarp, Jakob; Bugge, Anna; Laursen, Jens Ole; Jørgensen, Niklas Rye; Husby, Steffen; Wedderkopp, Niels; Mølgaard, Christian

doi:10.1016/j.bone.2019.02.005

Cited by 11 publications

(5 citation statements)

References 38 publications

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“…Despite a clear association between T2D and increased fracture risk[9,19,24], evidence supporting an association between prediabetes and fracture risk is inconsistent. Observations in adolescents suggest that insulin resistance may be detrimental for bone development through puberty, independent of body composition and the level of physical activity[25]. However, no association between insulin resistance and fracture risk was evident after adjustment for BMI and bone mineral density (BMD) in a large cohort of elderly subjects[26].…”

Section: Diabetes and Prediabetes: Clinical Impact On Bonementioning

confidence: 99%

“…Preclinical studies[25] documented alterations in transcription of osteoblasts promoting genes, in particular Runx2, which is involved in MSC differentiation into pre-OBs and in the regulation of bone matrix protein genes. Some preclinical studies suggested that Runx2 is downregulated by hyperglycemia[35,36], although other studies reported no modification[37,38].…”

Section: Diabetic Bone Disease-pathophysiologymentioning

confidence: 99%

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Bone health in diabetes and prediabetes

Costantini

Conte

2019

WJD

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Bone fragility has been recognized as a complication of diabetes, both type 1 diabetes (T1D) and type 2 diabetes (T2D), whereas the relationship between prediabetes and fracture risk is less clear. Fractures can deeply impact a diabetic patient’s quality of life. However, the mechanisms underlying bone fragility in diabetes are complex and have not been fully elucidated. Patients with T1D generally exhibit low bone mineral density (BMD), although the relatively small reduction in BMD does not entirely explain the increase in fracture risk. On the contrary, patients with T2D or prediabetes have normal or even higher BMD as compared with healthy subjects. These observations suggest that factors other than bone mass may influence fracture risk. Some of these factors have been identified, including disease duration, poor glycemic control, presence of diabetes complications, and certain antidiabetic drugs. Nevertheless, currently available tools for the prediction of risk inadequately capture diabetic patients at increased risk of fracture. Aim of this review is to provide a comprehensive overview of bone health and the mechanisms responsible for increased susceptibility to fracture across the spectrum of glycemic status, spanning from insulin resistance to overt forms of diabetes. The management of bone fragility in diabetic patient is also discussed.

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Section: Diabetes and Prediabetes: Clinical Impact On Bonementioning

confidence: 99%

Section: Diabetic Bone Disease-pathophysiologymentioning

confidence: 99%

Bone health in diabetes and prediabetes

Costantini

Conte

2019

WJD

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“…Furthermore, a recent clinical study in girls and boys aged 10e17 years showed an inverse association between the homeostasis model assessment of insulin resistance in boys and total body BMC. The association was independent of body composition, levels of osteocalcin or physical activity [28]. Insulin resistance seems to be mediating the negative association between adiposity and lumbar spine bone mass in children, as estimated in a sample of 240 children aged 7e15 years [29].…”

Section: Discussionmentioning

confidence: 82%

Impact of prenatal and postnatal nutritional manipulation on bone quality in adult Wistar rats offspring

Syggelos

Augoulea

Armeni

et al. 2021

Clinical Nutrition Open Science

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“…A mouse model showed that hyperinsulinemia and insulin resistance caused reduced bone turnover and led to increased bone fragility by increasing cortical porosity or other defects in bone microarchitecture ( 40 ). A longitudinal study showed that insulin resistance may be detrimental to bone development through puberty in boys ( 41 ). Thus, insulin resistance in offspring caused by high fructose during pregnancy may be one of the mechanisms that inhibit bone growth and development in offspring.…”

Section: Discussionmentioning

confidence: 99%

Effect of high-fructose consumption in pregnancy on the bone growth of offspring rats

Li,

Liu,

Chu

et al. 2023

Front. Nutr.

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Growing evidence suggests that bone health is programmed in early life. Maternal diet may influence the skeletal development of offspring. We aimed to determine the possible effects of high-fructose intake during pregnancy on different aspects of long bone morphology in the offspring of rats and to initially explore the possible mechanisms. Pregnant Sprague-Dawley rats were randomly divided into four groups and intragastrically administered the same dose of distilled water (CON, n = 12), 20 g/kg/day glucose (GLU, n = 12), 10 g/kg/day fructose (LFRU, n = 12), or 20 g/kg/day fructose (HFRU, n = 12) for 21 days during gestation. Computed tomography was used to analyze the cortical and cancellous bones of the distal femur of the offspring rats, and circulating bone metabolic biomarkers were measured using enzyme immunoassay. The results showed that high-fructose intake during pregnancy could decrease body weight, impair glucose metabolism, and increase serum leptin and uric acid in offspring. The offspring in the HFRU group had higher levels of the N-terminal propeptide of type I procollagen (PINP) and the C-telopeptide of type I collagen (CTX). The bone mean density (BMD), the total cross-sectional area inside the periosteal envelope (Tt.Ar), cortical bone area (Ct.Ar), medullary (or marrow) area (Ma.Ar), and trabecular mean density of the offspring in the HFRU group were lower than those in the CON group. Tartrate-resistant acid phosphatase (Trap) staining showed that high-fructose intake during pregnancy could increase the number of osteoclasts and increase the absorption area. Our results suggested that excessive fructose intake during pregnancy could inhibit skeletal development in offspring. Thus, attention to fructose intake during pregnancy is important for bone development in offspring.

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Bone mass development is sensitive to insulin resistance in adolescent boys

Cited by 11 publications

References 38 publications

Bone health in diabetes and prediabetes

Bone health in diabetes and prediabetes

Impact of prenatal and postnatal nutritional manipulation on bone quality in adult Wistar rats offspring

Effect of high-fructose consumption in pregnancy on the bone growth of offspring rats

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