Bone mass in female cynomolgus macaques: A cross-sectional and longitudinal study by age

Jayo, Manuel J.; Jerome, Christopher P.; Lees, Cynthia J.; Rankin, Samuel E.; Weaver, David

doi:10.1007/bf00301684

Cited by 83 publications

(67 citation statements)

References 20 publications

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“…Jayo et al [18] recently suggested that female cynomolgus monkeys achieve peak bone-mass at the age of 9, a result confirmed by our study, but Jayo et al found that the bone mass tended to decrease in older mature animals (>13.5 years), whereas we found no such decrease. The lumbar spine of cynomolgus monkeys consists of 7 vertebrae.…”

Section: Discussionsupporting

confidence: 88%

“…Only a few studies have shown that macaques undergo a natural pattern of change in bone mineralization that parallels the changes seen in humans. Previous studies suggest that bone mass peaks at 10-14 years of age in rhesus monkeys [3,28] and around 9 years of age in cynomolgus monkeys [18]. Precise determination of this peak will be important in the study of diseases associated with bone remodeling.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Aging on Bone Mineral Content and Bone Biomarkers in Female Cynomolgus Monkeys.

et al. 2000

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Age-related changes in bone mineral content and bone biomarkers were assessed over the complete lifespan of female cynomolgus monkeys. The bone mass of the lumbar spine increased linearly from birth to about 2.5 years of age, and this increase gradually slowed thereafter until a peak bone mass was achieved at 9 years of age. The bone mass stabilized after 9 years of age, showing no sign of further reduction with age. In contrast with the significant increase in bone mass before 2.5 years of age, significant decreases occurred in the serum concentrations of the following bone formation markers: intact osteocalcin, bone-specific alkaline phosphatase and amino-terminal propeptide of type I procollagen, but the serum concentration of carboxy-terminal propeptide of type I procollagen did not change significantly throughout the entire lifespan. Concerning the bone resorption markers, the levels of tartrate-resistant acid phosphatase fluctuated throughout the entire lifespan. The skeleton of an aging female monkey undergoes changes similar to those observed in senescent humans, but did not undergo the menopausal changes seen in women. The use of female cynomolgus monkeys to model human skeletal interventions should therefore be undertaken with consideration of the similarities and differences between cynomolgus monkeys and humans. Key words: bone densitometry, bone formation marker, bone resorption marker, cynomolgus monkeys, life span include reproductive endocrinology (menarche, regular menstruation and spontaneous menopause) [15], increases in bone turnover [20] and bone loss [26] in association with estrogen depletion, and skeletal microarchitecture as revealed by histomorphometry [19,

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Effects of Aging on Bone Mineral Content and Bone Biomarkers in Female Cynomolgus Monkeys.

et al. 2000

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“…OVX cynomolgus monkeys had increased serum levels of alkaline phosphatase and acid phosphatase compared with intact and hormone-supplemented animals (Jerome et al, 1994).…”

Section: Primates (Non-human)mentioning

confidence: 86%

“…Unfortunately, peak bone mass is not reached in cynomolgus monkeys until 9 years of age (Jayo et al, 1994), and most studies have used OVX monkeys aged 4-7 years (Jerome et al, 1993). Intuitively, OVX in the skeletally immature primate is an inappropriate model for postmenopausal osteoporosis.…”

Section: Primates (Non-human)mentioning

confidence: 99%

Animal models of osteoporosis - necessity and limitations

2001

eCM

243

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There is a great need to further characterise the available animal models for postmenopausal osteoporosis, for the understanding of the pathogenesis of the disease, investigation of new therapies (e.g. selective estrogen receptor modulators (SERMs)) and evaluation of prosthetic devices in osteoporotic bone. Animal models that have been used in the past include non-human primates, dogs, cats, rodents, rabbits, guinea pigs and minipigs, all of which have advantages and disadvantages. Sheep are a promising model for various reasons: they are docile, easy to handle and house, relatively inexpensive, available in large numbers, spontaneously ovulate, and the sheep's bones are large enough to evaluate orthopaedic implants. Most animal models have used females and osteoporosis in the male has been largely ignored. Recently, interest in development of appropriate prosthetic devices which would stimulate osseointegration into osteoporotic, appendicular, axial and mandibular bone has intensified. Augmentation of osteopenic lumbar vertebrae with bioactive ceramics (vertebroplasty) is another area that will require testing in the appropriate animal model. Using experimental animal models for the study of these different facets of osteoporosis minimizes some of the difficulties associated with studying the disease in humans, namely time and behavioral variability among test subjects. New experimental drug therapies and orthopaedic implants can potentially be tested on large numbers of animals subjected to a level of experimental control impossible in human clinical research.

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“…Καθώς η μετεμμηνοπαυσιακή οστεοπόρωση είναι ένα ορμο νικά εξαρτώμενο νόσημα στον άνθρωπο, οι ομοιότη τες που παρατηρούνται μεταξύ του ανθρώπου και των πρωτευόντων στα ενδοκρινικά τους συστήματα είναι ένα σημαντικό πλεονέκτημα ως προς τη χρήση των πρωτευόντων στην έρευνα της μετεμμηνοπαυσιακής οστεοπόρωσης. Δυστυχώς, η ηλικία απόκτησης κορυ φαίας οστικής πυκνότητας σε αυτά τα ζωικά είδη (cynomolgus maqaques) επέρχεται μετά την ηλικία των 9 ετών (Jayo et al 1994), ενώ οι περισσότερες μελέτες οστεοπόρωσης έχουν πραγματοποιηθεί σε ωοθηκε-κτομημένα πρωτεύοντα ηλικίας μόλις 4-7 ετών (Jerome et al 1993). Η απώλεια των οιστρογόνων σε σκελετικά ανώριμα ζωικά πρότυπα δεν είναι κατάλ ληλο πρότυπο για τη μελέτη της μετεμμηνοπαυσιακής οστεοπόρωσης.…”

Section: πρωτεύονταunclassified

Animal models of osteoporosis

Lelovas

2017

J Hellenic Vet Med Soc

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Osteoporosis is an important systemic disorder, affecting mainly Caucasian women, with a diverse and multifactorial aetiology. A large variety of animal species, such as rodents, rabbits, dogs, sheep and primates, have been used as animal models in osteoporosis research. Their use enhanced our understanding on the etiology of osteoporosis. Additionally, many therapeutic regimes have entered clinical practice after evaluation on animal models. Experimental protocols leading to bone loss include hormonal interventions (ovariectomy, orchidectomy, hypophysectomy, parathyroidectomy), immobilization, alcohol abuse osteoporosis and osteoporosis induced by food manipulation. Methods of bone mass evaluation, used on animal models, are biochemical markers, densitometry, magnetic resonance imaging, histomorphometry and bone mechanical testing.

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Bone mass in female cynomolgus macaques: A cross-sectional and longitudinal study by age

Cited by 83 publications

References 20 publications

Effects of Aging on Bone Mineral Content and Bone Biomarkers in Female Cynomolgus Monkeys.

Effects of Aging on Bone Mineral Content and Bone Biomarkers in Female Cynomolgus Monkeys.

Animal models of osteoporosis - necessity and limitations

Animal models of osteoporosis

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