Bone Metabolism Markers in Sportswomen with Menstrual Cycle Dysfunctions

Ponorac, Nenad; Rašeta, Nela; Radovanović, Dragan; Matavulj, Amela; Popadić-Gaćeša, Jelena

doi:10.2478/v10011-011-0012-8

Cited by 6 publications

(3 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The frequency of all menstrual dysfunctions was greater in groups of athletes in relation to the control group. Primary amenorrhea was determined in 8.33% and oligomenorrhea in 13.09% of female athletes (Ponorac, Rašeta, Radovanović, Matavulj, & Popadić-Gaćeša, 2011) One of the most appropriate mechanisms of menstrual disorders in sports includes also eating disorders. Energy access/availability is defined as the energy calorie intake minus the energy consumed during physical activity.…”

Section: Menstrual Cycle Disordersmentioning

confidence: 99%

Women and sport

Ponorac¹,

Palija²,

Popović³

2013

sgai

View full text Add to dashboard Cite

Regular physical activity is important for the health of both sexes. However, the physiological, anatomical, psychological and socio-cultural specificities of women require special considerations in all aspects of their sports. Puberty brings gender differences that result from different sexual functioning of endocrine axis. Despite the identical mechanisms of adaptation to physical activity, sexually mature women and men have inherited anatomical and physiological differences in body composition, aerobic capacity-building and muscle strength. In particular, it relates to the more complex female reproductive system. The female reproductive system is a functional part of the human body most sensitive to stress caused by heavy physical exertion. The most common disorders whose risk was significantly increased in physically active women are eating disorder, disturbed menstrual cycle, infertility, intimidated fractures, rupture of the anterior cruciate ligament, or even death. Mainly those are result of blunders and ignorance. Fortunately, they are largely preventable

show abstract

Section: Menstrual Cycle Disordersmentioning

confidence: 99%

Women and sport

Ponorac¹,

Palija²,

Popović³

2013

sgai

View full text Add to dashboard Cite

show abstract

“…In addition, a number of research studies demonstrated the role of vitamin D in blood pressure regulation, autoimmunity, regulation of cell growth and metabolic diseases and malignancy (2)(3)(4)(5)(6)(7)(8)(9). This has all led to increase in vitamin D testing requests, with many laboratories in the United States reporting annual increase rates of 50% or more (10 (17,18).…”

Section: Introductionmentioning

confidence: 99%

Analytical methods and performance of the immunoassay methods for determination of vitamin d in comparison to mass spectrometry / Analitičke metode i izvođenje imunometrijskih određivanja vitamina d u poređenju sa masenom spektrometrijom

Babić¹

2012

Journal of Medical Biochemistry

View full text Add to dashboard Cite

Summary: Demand for vitamin D testing has been on a constant rise worldwide, partially due to mounting evidence linking vitamin D status to overall health and well-being. Currently available assays measure 25-hydroxy vitamin D (25-OHD), a major circulating form of vitamin D. Available methodologies include immunoassays and mass spectrometry based methods (LC-MS/MS). Until recently, the only immunoassays available for diagnostic use in the US have been DiaSorin radioimmunoassay (RIA) and an automated immunoassay on a LIAISON ® platform. Within the last year, Siemens and Abbott successfully launched immunoassays for determination of total vitamin D on their respective automated platforms, Centaur ® and ARCHITECT ® . Development of robust and precise Vitamin D immunoassays has historically been plagued with difficulty. One of the major challenges is development of specific antibodies against such a small antigen. Vitamin D is also highly hydrophobic molecule predominantly bound to vitamin D binding protein (DBP). It is likely, therefore, that immunoassays might be affected to varying extent by the DBP concentration. Adoption of LC-MS/MS into clinical laboratories has enabled development of accurate and almost fully automated methods that could handle increasing volume demands, especially in large volume reference laboratories. Smaller to mid-size hospital laboratories as well as physician offices have neither funds nor technical expertise to implement LC-MS/MS based testing. Our laboratory at the University of Chicago Medical Center has also seen increase in vitamin D volume and currently performs close to 20,000 25-OHD assays per year. We have recently developed an LC-MS/MS method for quantitation of 25-OHD 2 (obtained from plant sources) and 25-OHD 3 (endogenous and animal sources). Prior to acquisition of LC-MS/MS Kratak sadr`aj: Broj zahteva za odre|ivanjem vitamina D je u konstantnom porastu {irom sveta, delom zbog sve vi{e dokaza koji povezuju status vitamina D sa op{tim zdravljem. Trenutno raspolo`ivim testovima odre|uje se 25-hidroksi vitamin D (25-OHD), glavni oblik vitamina D u cirkulaciji. Po stoje}e metodologije uklju~uju imunometrijska odre |i vanja i tehnike zasnovane na masenoj spektrometriji (LC-MS/MS). Do nedavno, jedine raspolo`ive imunometrijske metode kori{}ene za dijagnostiku u SAD su bile DiaSorin radioimunoodre|ivanje (RIA) i automatizovano imuno odre|ivanje na LIAISON ® platformi. U toku pro{le godine Siemens i Abbott su uspe{no lansirali imunometrijske testove za odre|ivanje ukupnog vitamina D na svojim odgova raju}im automatizovanim platformama, Centaur ® i ARCHI-TECT ® . Razvoj robusnih i preciznih imunometrijskih testova za odre|ivanje vitamina D su, istorijski gledano, pratili problemi. Jedan od najve}ih izazova je razvoj specifi~nih antitela protiv malog antigena. Vitamin D je tako|e jako hidrofoban molekul predominantno vezan za vitamin D vezu ju}i protein (DBP). Stoga postoji verovatno}a da na imuno odre|ivanja u razli~itom stepenu mo`e da uti~e koncentracija DBP. Uvo|enje LC-MS/MS u...

show abstract

“…Bone biomarkers and markers of bone changes are the indicators of bone metabolism derived from the bone matrix or bone cells. In making a diagnosis of osteoporosis, in addition to medical history, assessment of the risk factors, clinical examination and certain laboratory tests, the most important is the determination of mass and bone density and the assessment of bone metabolic activity (8,9). The dynamic state of bone metabolism could also provide information about early pathological changes in the bones and the risk of some diseases of the locomotor apparatus.…”

Section: Introductionmentioning

confidence: 99%

Effects of Tibolone on Markers of Bone Metabolic Activity in Postmenopausal Women

Krejovic¹,

Živanović²,

Živanović³

et al. 2012

Journal of Medical Biochemistry

View full text Add to dashboard Cite

Summary: Osteoporosis, a systemic disease of the bones, is a serious health and socio-economic problem because of its consequences, i.e. broken bones. It is believed that 10% of the world's population suffers from osteoporosis and it affects mostly postmenopausal women (postmenopausal osteoporosis). Tibolone is a synthetic steroid that has estrogenic, androgenic, and progestagenic properties. It has been used primarily for the prevention of postmenopausal osteoporosis and treatment of climacteric symptoms. The research included a group of 40 postmenopausal women with osteopenia treated with tibolone. The control group included 40 postmeno pausal women who were not taking any medication. Control group patients were older (54.5 ± 9.84) than the patients treated with tibolone (51.6 ± 6.22). Bone meta bolic activity was evaluated using osteocalcin (N-MID osteocalcin) for bone formation and CTX I for bone resorption. Blood samples were taken before therapy was introduced and 3 months after its introduction. The average value of osteocalcin after three months of tibolone therapy was 26.32 ± 3.312 ng/mL compared to the average osteocalcin value prior to the rapy of 29.6 ± 3.343 ng/mL. The average value of CTX I three months after tibolone therapy of 0.2870 ± 0.0783 ng/mL was lower compared to the average CTX I value before the therapy of 0.4539 ± 0.1144 ng/mL. Our results show the efficacy of tibolone in preventing bone loss, which was highly statistically significant. They also reveal its suppressive effects on bone for mation and resorption, but these effects are statistically less significant. Tibolone signifKratak sadr`aj: Osteoporoza, sistemsko oboljenje kostiju, predstavlja ozbiljan zdravstveni i socijalno-ekonomski problem zbog svojih posledica, preloma kostiju. Smatra se da 10% svetske populacije boluje od osteoporoze, a posebno su ugro `ene `ene u postmenopauzi. Tibolon je tkivno specifi~an steroid sa estrogenim, progestagenim i androgenim svojstvima. Prvenstveno se koristi za prevenciju postmenopauzalne osteoporoze i ubla`avanje klimakteri~nih tegoba. Istra`ivanje je sprovedeno u grupi od 40 `ena sa osteopenijom u postmenopauzi tretiranih tibolonom. Kontrolnu grupu ~inilo je 40 `ena u postmenopauzi koje nisu uzimale nikakvu terapiju. Pacijentkinje kontrolne grupe bile su starije (54,5 ± 9,84) od pacijentkinja tretiranih tibolonom (51,6 ± 6,22). Od para metara metaboli~ke aktivnosti kosti kori{}eni su osteo kalcin kao parametar formiranja kosti i CTX I kao parametar resorpcije kosti. Krv je va|ena pre uvo|enja terapije i 3 meseca nakon uvo|enja terapije. Prose~na vrednost osteokalcina tri meseca nakon terapije tibolonom je bila ni`a (26,32 ± 3,312 ng/mL) u odnosu na prose~nu vrednost osteokalcina pre terapije (29,6 ± 3,343 ng/mL). Prose~na vrednost CTX I tri meseca nakon terapije tibolonom je bila ni`a (0,2870 ± 0,0783 ng/mL) u odnosu na prose~na vrednost CTX I pre te rapije (0,4539 ± 0,1144 ng/mL). Na{i rezultati pokazali su izrazito koristan uticaj tibolona na ko{tanu resorpciju i supresivni efekat na ko{tan...

show abstract

Bone Metabolism Markers in Sportswomen with Menstrual Cycle Dysfunctions

Cited by 6 publications

References 31 publications

Women and sport

Women and sport

Analytical methods and performance of the immunoassay methods for determination of vitamin d in comparison to mass spectrometry / Analitičke metode i izvođenje imunometrijskih određivanja vitamina d u poređenju sa masenom spektrometrijom

Effects of Tibolone on Markers of Bone Metabolic Activity in Postmenopausal Women

Contact Info

Product

Resources

About