Bone metastases from squamous cell carcinoma of the head and neck

With locally advanced ENT tumor stage IVa/b, carcinoma of the hypopharynx, local recurrence or second neoplasms, at least a pretherapeutic CT of the thorax should be performed because every seventh patient (88/600) developed metastases or second primary tumors within the thoracic space during the course of disease. Regarding the side effects and costs of curative therapy, the definition of generally accepted guidelines for the systemic staging of locally advanced ENT tumors should be undertaken.

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“…Abdomensonographie aufgrund der geringen organspezifischen Metastasenprävalenz nicht sinnvoll erscheint [18,22].…”

Section: Diskussionmentioning

(Expert classified)

Häufigkeit und Topographie von Fernmetastasen bei Patienten mit HNO-Tumoren und ihre onsequenzen für das prätherapeutische Staging

et al. 2007

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“…While bone metastases have been generally considered a rare and late event in patients with head and neck cancer (HNC), the reported incidence varies with tumor site, ranging from 50%-80% in patients with nasopharyngeal carcinoma (NPC) [4,5] to 2%-22% in squamous cell non-NPC [3,6–8]. The prognosis of HNC patients with bone metastases is reportedly poor and the expected overall survival often does not exceed 8 months [7,9]. Furthermore, bone involvement greatly diminishes quality of life since it causes bone pain and skeletal-related events (SREs) such as bone fractures, spinal cord compression, and hypercalcemia [10].…”

Section: Introductionmentioning

confidence: 99%

Bone metastases from head and neck malignancies: Prognostic factors and skeletal-related events

et al. 2019

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BackgroundWe conducted a multicenter retrospective analysis to describe the characteristics, frequency of skeletal-related events (SREs), and prognosis of head and neck cancer (HNC) in patients with bone metastases (BM).Patients and methodsThe data of 192 HNC patients with BMs were collected. Analyses were conducted separately in 64 nasopharyngeal cancer (NPC) patients and in 128 non-NPC patients.ResultsSREs occurred in 34 (27%) non-NPC and in 6 (9%) NPC patients, respectively. Median overall survival (OS) was 25 and 6 months in NPC and non-NPC patients, respectively. Locoregional recurrence (hazard ratio [HR] 2.33, 95% confidence interval (CI) 1.1–4.93), synchronous BM (HR 0.25, 95% CI 0.59–0.71) and bone-directed therapies (BDT) (HR 0.26, 95% CI 0.10–0.68) were independent prognostic factors for OS in NPC patients. Combined bone radiotherapy (RT) and BDT in NPC patients obtained longer survival (38 months) than either therapy alone (25 months) or neither of these therapies (8 months).ConclusionsPatients with BMs from non-NPC have a poor prognosis and are at high risk of SREs. NPC patients with BMs are at relatively low risk of SREs. BDT may potentially improve survival, particularly when combined with bone RT. This last finding deserves prospective confirmation.

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“…Pietropaoli et al . [ 16 ] reviewed radiographs and nuclear medicine studies of 363 patients of head and neck cancers retrospectively. He saw that 1% of these cases had developed bone metastasis mainly involving the pelvic bones, femur, humerus, ribs, and thoracic vertebra.…”

Section: Discussionmentioning

confidence: 99%

Incidence of bone metastasis in carcinoma buccal mucosa

Bhandari

2016

Indian J Med Paediatr Oncol

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Introduction:Head and neck cancer is a leading health problem in India due to the habit of chewing tobacco and bad oral and dental hygiene. Carcinoma buccal mucosa is more common and is 2.5% of all malignancies at our center. Most of the patients present in stage III and IV and the survival in these cases is not very good. Bone metastasis in advanced cases of carcinoma buccal mucosa is rarely reported in the world literature.Materials and Methods:We present here cases developing bone metastasis in carcinoma buccal mucosa in last 5 years. These patients were young with loco-regionally advanced disease where bone metastasis developed within 1-year of definitive treatment.Results:The flat bones and vertebrae were mainly involved and the survival was also short after diagnosis of metastasis despite the treatment with local Radiotherapy and chemotherapy.Conclusion:The exact cause of metastasis cannot be proved, but the probability of subclinical seedling of malignant cells before the eradication of the primary tumor should be considered along with advanced local and nodal disease with high grade of tumor.

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Bone metastases from squamous cell carcinoma of the head and neck

Cited by 23 publications

References 12 publications

Häufigkeit und Topographie von Fernmetastasen bei Patienten mit HNO-Tumoren und ihre onsequenzen für das prätherapeutische Staging

Häufigkeit und Topographie von Fernmetastasen bei Patienten mit HNO-Tumoren und ihre onsequenzen für das prätherapeutische Staging

Bone metastases from head and neck malignancies: Prognostic factors and skeletal-related events

Incidence of bone metastasis in carcinoma buccal mucosa

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