Bone Mineral Affinity of Polyphosphodiesters

Iwasaki, Yasuhiko

doi:10.3390/molecules25030758

Cited by 18 publications

(14 citation statements)

References 37 publications

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“…Over the past few years, synthetic polymers containing acidic phosphate groups have been the subject of extensive research [ 1 , 2 , 3 , 4 , 5 , 6 , 7 ]. Their similarity to environmental inorganic polyphosphates [ 8 , 9 ], nucleic acids [ 10 ] and teichoic acids (TAs) [ 11 ] ( Scheme 1 a), as well as the biocompatibility of the phosphate group [ 5 , 12 ], offers great opportunities for the use of these polymers for different biomedical [ 1 , 2 , 5 , 13 , 14 , 15 , 16 , 17 ], industrial [ 4 , 18 ] and household [ 19 ] applications.…”

Section: Introductionmentioning

confidence: 99%

Design, Synthesis and Actual Applications of the Polymers Containing Acidic P–OH Fragments: Part 1. Polyphosphodiesters

Nifant’ev

Ivchenko

2022

IJMS

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Among natural and synthetic polymers, main-chain phosphorus-containing polyacids (PCPAs) (polyphosphodiesters), stand in a unique position at the intersection of chemistry, physics, biology and medicine. The structural similarity of polyphosphodiesters PCPAs to natural nucleic and teichoic acids, their biocompatibility, mimicking to biomolecules providing the ‘stealth effect’, high bone mineral affinity of polyphosphodiesters resulting in biomineralization at physiological conditions, and adjustable hydrolytic stability of polyphosphodiesters are the basis for various biomedical, industrial and household applications of this type of polymers. In the present review, we discuss the synthesis, properties and actual applications of polyphosphodiesters.

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Section: Introductionmentioning

confidence: 99%

Design, Synthesis and Actual Applications of the Polymers Containing Acidic P–OH Fragments: Part 1. Polyphosphodiesters

Nifant’ev

Ivchenko

2022

IJMS

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“…As described before, a PPE with phosphodiester linkages in the polymer backbone shows high mineral affinity. Therefore, studies investigated bone affinity in vivo [ 18 , 101 ]. To track the biodistribution of phosphodiester PPE (PEP•Na) in vivo, fluorescence-labeled PEP•Na (Cy5-PEP•Na) was synthesized and Cy5-PEP•Na or Cy5-azide (Cy5-Az) was injected into the tail veins of Institute of Cancer Research (ICR) mice.…”

Section: Bone Targetingmentioning

confidence: 99%

“…Therefore, the control of the physicochemical properties of PPEs and molecular conjugation are flexible. According to versatile molecular design capabilities, unique materials such as transdermal penetrating emulsions [ 17 ] and bone-targeting macromolecular vehicles [ 18 ] have been proposed.…”

Section: Introductionmentioning

confidence: 99%

Controlled biointerfaces with biomimetic phosphorus-containing polymers

Hiranphinyophat

Iwasaki

2021

Science and Technology of Advanced Materials

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Phosphorus is a ubiquitous and one of the most common elements found in living organisms. Almost all molecules containing phosphorus in our body exist as analogs of phosphate salts or phosphoesters. Their functions are versatile and important, being responsible for forming the genetic code, cell membrane, and mineral components of hard tissue. Several materials inspired from these phosphorus-containing biomolecules have been recently developed. These materials have shown unique properties at the biointerface, such as nonfouling ability, blood compatibility, lubricity, mineralization induction capability, and bone affinity.Several unfavorable events occur at the interface of materials and living organisms because most of these materials have not been designed while taking host responses into account. These unfavorable events are directly linked to reducing functions and shorten the usable periods of medical devices.Biomimetic phosphorus-containing polymers can improve the reliability of materials in biological systems. In addition, phosphorus-containing biomimetic polymers are useful not only for improving the biocompatibility of material surfaces but also for adding new functions due to the flexibility in molecular design.In this review, we describe the recent advances in the control of biointerfacial phenomena with phosphorus-containing polymers. We especially focus on zwitterioninc phosphorylcholine polymers and polyphosphoesters.

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“…Meanwhile, PPE-PLA block copolymers have also been shown to increase mineral deposition and the attachment and proliferation of osteoblasts [219]. Indeed, polyphosphoesters have also generated much interest for their strong affinity for biominerals [220], with the ionized phosphodiester unit as the key element exhibiting mineral affinity [220,221]. Polyether ether ketones (PEEK) are clinically used as a replacement for metallic orthopedic implants, but they have been demonstrated to show improved CaP mineral nucleation and biomineralization when coated with PPE (Figure 45) [222].…”

Section: Degradable Scaffolds For Tissue Regenerationmentioning

confidence: 99%

Main-Chain Phosphorus-Containing Polymers for Therapeutic Applications

Strasser

Teasdale

2020

Molecules

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Polymers in which phosphorus is an integral part of the main chain, including polyphosphazenes and polyphosphoesters, have been widely investigated in recent years for their potential in a number of therapeutic applications. Phosphorus, as the central feature of these polymers, endears the chemical functionalization, and in some cases (bio)degradability, to facilitate their use in such therapeutic formulations. Recent advances in the synthetic polymer chemistry have allowed for controlled synthesis methods in order to prepare the complex macromolecular structures required, alongside the control and reproducibility desired for such medical applications. While the main polymer families described herein, polyphosphazenes and polyphosphoesters and their analogues, as well as phosphorus-based dendrimers, have hitherto predominantly been investigated in isolation from one another, this review aims to highlight and bring together some of this research. In doing so, the focus is placed on the essential, and often mutual, design features and structure–property relationships that allow the preparation of such functional materials. The first part of the review details the relevant features of phosphorus-containing polymers in respect to their use in therapeutic applications, while the second part highlights some recent and innovative applications, offering insights into the most state-of-the-art research on phosphorus-based polymers in a therapeutic context.

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Bone Mineral Affinity of Polyphosphodiesters

Cited by 18 publications

References 37 publications

Design, Synthesis and Actual Applications of the Polymers Containing Acidic P–OH Fragments: Part 1. Polyphosphodiesters

Design, Synthesis and Actual Applications of the Polymers Containing Acidic P–OH Fragments: Part 1. Polyphosphodiesters

Controlled biointerfaces with biomimetic phosphorus-containing polymers

Main-Chain Phosphorus-Containing Polymers for Therapeutic Applications

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