Bone mineral density and fracture in postmenopausal women

Meltzer, Michele; Lessig, Harry J.; Siegel, Jeffrey A.

doi:10.1016/0378-5122(90)90104-e

Cited by 6 publications

(8 citation statements)

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“…In another study of non-black women followed for a period of 8 months, peripheral measurements were as good as axial measurements for the prediction of spine fractures [39]. Several studies have not provided evidence that site-specific measurements are better predictors of spine or forearm fractures [2,[40][41][42][43][44][45][46]. There is evidence, however, to suggest that a measure of femoral bone mass may be a better predictor of subsequent risk of femoral fracture than a measure of the lumbar spine, radius or calcaneus.…”

Section: Discussionmentioning

confidence: 93%

Comparative Assessment of Bone Mineral Measurements Using Dual X-ray Absorptiometry and Peripheral Quantitative Computed Tomography

Formica

Nieves

Cosman

et al. 1998

Osteoporosis International

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A measurement of bone mass is the single most important determinant of future fracture. However, controversy exists as to which technique (dual X-ray absorptiometry (DXA) or peripheral quantitative computed tomography (pQCT), and which site of skeletal measurement (axial vs appendicular) provides the best prediction of fracture risk. The aims of this study were: (1) to determine the ability of pQCT to predict bone mass of the lumbar spine, proximal femur, and distal forearm measured using DXA, and (2) to compare the ability of DXA and pQCT to discriminate prevalent fractures in women with established osteoporosis. One hundred and sixty-five women were studied, including 47 with established osteoporosis (vertebral, hip or Colles' fractures) as well as 118 who had bone mass measurements to assess osteoporosis risk. Each subject had bone mass measured by DXA at the lumbar spine and femoral neck, and at the distal radius by both DXA and pQCT. In women with fractures, bone mass, when expressed as a standardized score, was in general lower using DXA compared with the appendicular skeleton measured using pQCT. Bone mass determinations at all sites were significantly correlated with each other. The highest correlation coefficients were observed within the axial skeleton. In women with fractures, the highest odds ratios were observed at skeletal regions measured using DXA. Likewise, the areas under the receiver-operating characteristic (ROC) curves were comparable at all skeletal regions measured using DXA; and were significantly greater than the areas under the ROC curves for pQCT measurements. In summary, the strongest discriminators of prevalent fractures were measurements using DXA. Measurements of bone mass at the appendicular skeleton, using either DXA or pQCT, were poorly associated with axial bone mass. PQCT has the poorer ability to discriminate persons with fractures, and appears to be less sensitive than measurements using DXA.

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Section: Discussionmentioning

confidence: 93%

Comparative Assessment of Bone Mineral Measurements Using Dual X-ray Absorptiometry and Peripheral Quantitative Computed Tomography

Formica

Nieves

Cosman

et al. 1998

Osteoporosis International

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“…The BMD of patients with FXf in all these studies was significantly diminished compared with agematched controls. The average BMD level of the femoral neck in patients with FXF seems therefore to be constant (a) across age, and (b) across populations, since similar values have been reported in both Asian [25] and white populations [24,[26][27][28].…”

Section: Discussionmentioning

confidence: 99%

Bone mineral density in patients with cervical and trochanteric fractures of the proximal femur

Vega

Mautalén

Gómez³

et al. 1991

Osteoporosis Int

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The bone mineral density (BMD) of the proximal femur, spine and radius shaft was determined in 75 women with atraumatic fractures of the proximal femur (FXf) (average age: 70.1 +/- 9.6 years) and 51 controls of similar age. Fractures were classified as either cervical (n = 36) or trochanteric (n = 39) on the basis of radiographic and surgical finding. The BMD of spine and proximal femur was determined by dual-photon absorptiometry (Lunar DP3) and the BMD of the radius shaft by single photon absorptiometry. The BMD of patients with FXf was significantly decreased over all skeletal sites compared to controls of similar age. No significant correlation was found between age and the BMD of the femoral neck in patients with FXf. Patients with trochanteric FXf were older and thinner (average: age, 72.9 +/- 9.4 years; weight, 53.1 +/- 7.8 kg) compared with patients with cervical fractures (age, 67.2 +/- 8.9 years; weight, 59.3 +/- 8.3 kg). Likewise the BMD of trochanteric FXf was lower at all measured sites: femoral neck, 0.548 +/- 0.066 g/cm2 vs 0.624 +/- 0.055 g/cm2 (P less than 0.001); L2-L4, 0.799 +/- 0.115 g/cm2 vs 0.925 +/- 0.106 g/cm2 (P less than 0.001); radius shaft, 0.454 +/- 0.057 g/cm2 vs 0.502 +/- 0.083 g/cm2 (P less than 0.05). Of the patients with trochanteric fractures 66% had concomitant vertebral fractures, while this occurred in only 28% of the patients with cervical fractures (P (Fisher) = 0.0007). In summary, females with trochanteric FXf are older, thinner, have less bone mass in all measured sites and suffer with a significantly greater frequency of vertebral fractures.(ABSTRACT TRUNCATED AT 250 WORDS)

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“…The age-related bone loss and increased tendency to fall have been demonstrated as the main factors causing hip fracture [2,[4][5][6][7][8][9][10][11][12][13][14][15][16]. Previous reports have shown a lower bone mineral density (BMD) of the proximal femur in subjects with hip fracture than in age-matched controls [2,4,5,7,9,10,12,13].…”

Section: Introductionmentioning

confidence: 99%

“…The incidence of hip fracture in the elderly increases exponentially with aging [1][2][3][4][5][6][7][8][9]. The age-related bone loss and increased tendency to fall have been demonstrated as the main factors causing hip fracture [2,[4][5][6][7][8][9][10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Proximal Femoral Dimension in Elderly Chinese Women with Hip Fractures in Taiwan

Yang

Wang

Liu

1999

Osteoporosis International

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To investigate the relationship between proximal femoral geometry and the occurrence of hip fracture, we compared the geometry of contralateral normal hips of 120 elderly Chinese women with hip fractures, including 63 femoral neck fractures (group A) and 57 intertrochanteric fractures (group B) due to minor trauma, with that of 72 normal elderly Chinese women (group C). The mean ages for group A, B and C subjects were 77.3, 79.7 and 72.9 years, respectively. The femoral neck length (NL), neck width (NW), diameter of femoral head, femoral shaft width just below the lesser trochanter, and neck-shaft angle (theta;) were measured on the anteroposterior plain pelvic radiographs. The mean +/- SD of NL for group A was 50.4 +/- 3.3 mm; for group B, 50.6 +/- 3.1 mm; and for group C, 48.8 +/- 3.6 mm. Statistical analysis by ANOCOVA and regression showed that only NL of women with hip fractures was significantly longer than controls after correction for age, body height and weight (p <0.01). However, the difference in NL between group A and group B was not significant. By linear regression, the probability of fracture increased only with older age (p <0.001), longer NL (p <0.005) and lighter body weight (p <0.05). By logistic regression, each standard deviation increase in NL increased the risk of hip fracture (age-adjusted odds ratio 1.84; 95% CI, 1.11-3.06). The results confirm the relationship between proximal femoral geometry and the occurrence of hip fracture in elderly Chinese women in Taiwan.

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Bone mineral density and fracture in postmenopausal women

Cited by 6 publications

References 0 publications

Comparative Assessment of Bone Mineral Measurements Using Dual X-ray Absorptiometry and Peripheral Quantitative Computed Tomography

Comparative Assessment of Bone Mineral Measurements Using Dual X-ray Absorptiometry and Peripheral Quantitative Computed Tomography

Bone mineral density in patients with cervical and trochanteric fractures of the proximal femur

Proximal Femoral Dimension in Elderly Chinese Women with Hip Fractures in Taiwan

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