Bone mineralization

Betts, F.; Blumenthal, Norman C.; Posner, Aaron S.

doi:10.1016/0022-0248(81)90056-7

Cited by 93 publications

(67 citation statements)

References 27 publications

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“…Labile (adsorbed) carbonate is not associated with a well-defined lattice position. Instead, it is adsorbed on to the surfaces of apatite crystals or incorporated into less mature, more disorganized regions of apatite crystals [3,6,25,27]. It is more easily dissolved and altered than the more stable structural carbonate.…”

Section: Current Preparation Methodsmentioning

confidence: 99%

Preparation of bone carbonate for stable isotope analysis: the effects of treatment time and acid concentration

Garvie‐Lok

Varney

Katzenberg

2004

Journal of Archaeological Science

204

152

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Section: Current Preparation Methodsmentioning

confidence: 99%

Preparation of bone carbonate for stable isotope analysis: the effects of treatment time and acid concentration

Garvie‐Lok

Varney

Katzenberg

2004

Journal of Archaeological Science

204

152

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“…According to the X-ray diffraction data the main inorganic component of calcified tissues (bone and teeth) is identified as a single-phase mineral which pertains to the apatite family, Ca 10 (PO 4 ) 6 (OH) 2 [1,2]. However, many investigators indicate that its structure resembles that of a poorly crystalline apatite due to small crystal size, high specific surface, non-stoichiometry, internal crystal disorder and impurities [2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

“…However, many investigators indicate that its structure resembles that of a poorly crystalline apatite due to small crystal size, high specific surface, non-stoichiometry, internal crystal disorder and impurities [2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Carbonate location in bone tissue mineral by X-ray diffraction and temperature-programmed desorption mass spectrometry

Danilchenko¹,

Pokrovskiy²,

Bogatyrov³

et al. 2005

Cryst. Res. Technol.

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The thermal behavior of bone mineral samples was investigated in the range from 600 to 900ºC by X-ray diffraction with line broadening analysis and temperature-programmed desorption mass spectrometry. At least two stages of CO 3 2-release during the thermal evolution were observed, each can be attributed to a different type of carbonate location in the bone mineral. The elimination of CO 3 2-occurring without pronounced variations in the substructural parameters of the biomineral nanocrystals is ascribed to the surface carbonate, while the elimination of CO 3 2-accompanied by the growth of crystals and disappearance of structural distortions is attributed to the lattice carbonate. The sample of affected immature bone with low bioapatite crystallinity was found to have the surface carbonate content greater than the amount of carbonate in the lattice, while for the mature healthy bone the situation is reverse.

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“…Reports of the presence of vesicles in the extracellular matrix and of amorphous calcium phosphate mineral in developing bone, started to emerge nearly half-a-century ago 41,42 . Whereas the plasma calcium level is high, intracellular calcium is kept low by sequestration by cytosolic organelles and proteins, yet calcium needs to be labile for its signalling role 3 .…”

Section: Compartmentalization Of Calcium and Phosphate Ionsmentioning

confidence: 99%

A materials science vision of extracellular matrix mineralization

et al. 2016

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From an engineering perspective, skeletal tissues are remarkable structures in that they are lightweight, stiff and tough, yet produced at ambient conditions. The biomechanical success of skeletal tissues is largely attributable to the process of biomineralization -a tightly regulated, cell-driven formation of billions of inorganic nanocrystals formed from ions found abundantly in body fluids. In this Review, we discuss nature's strategies to produce and sustain appropriate biomechanical properties in mineralizing (by promotion of mineralization) and nonmineralizing (by inhibition of mineralization) tissues. We review how perturbations of biomineralization are controlled over a continuum which spans from the desirable (or defective in disease) mineralization of the skeleton, to pathological cardiovascular mineralization, and to mineralization of bioengineered constructs. A materials science vision of mineralization is presented with an emphasis on the micro-and nanostructure of mineralized tissues recently revealed by state-of-the-art analytical methods, and on how biomineralization-inspired designs are impacting the field of synthetic materials. Web summaryComplex mechanisms are at play in the biomineralization of skeletal tissues and in patholological calcification in the cardiovascular system. In this Review, the physiochemical and biomechanical properties of mineralized tissues, both physiologic and pathophysiologic, and analytical methods to elucidate their finer structure are discussed.

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Bone mineralization

Cited by 93 publications

References 27 publications

Preparation of bone carbonate for stable isotope analysis: the effects of treatment time and acid concentration

Preparation of bone carbonate for stable isotope analysis: the effects of treatment time and acid concentration

Carbonate location in bone tissue mineral by X-ray diffraction and temperature-programmed desorption mass spectrometry

A materials science vision of extracellular matrix mineralization

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