Bone Morphogenetic Protein-2 Stimulation of Cartilage Regeneration in Canine Tracheal Graft

Li, Xiaofei; Wang, Jian; Ni, Yicheng; Yan, Xiaolong; Lü, Qiang; Xu, Hong; Cheng, Qi; Liu, Kun

doi:10.1016/j.healun.2008.12.013

Cited by 5 publications

(4 citation statements)

References 29 publications

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“…[10][11][12][13][14][15][16][17][18] Basic fibroblast growth factor and vascular endothelial growth factor have been studied in tracheal transplants for their strong revascularization effects, and we have also successfully stimulated cartilage regeneration in tracheal grafts with BMP-2. 10 Although vascular endothelial growth factor was of great benefit to tracheal grafts, it may increase the development of tracheal luminal occlusion through signaling pathways mediated by platelet-derived growth factor to recruit mononuclear inflammatory cells. 15,16 FIGURE 3.…”

Section: Discussionmentioning

confidence: 99%

“…Ideally, to resolve this problem, first, growth factors should be applied persistently without interrupting the vitality of grafts; second, an effective concentration of growth factors should be maintained around the tracheal grafts; and third, the method should be simple and convenient. There have been many methods for administration of growth factors, such as direct local application, 11 nebulization therapy, 17 use of biomaterials as vectors, 10,[12][13][14] and gene therapy. 15 These methods have their own disadvantages, however, and ideal methods of administration still remain to be achieved.…”

Section: Discussionmentioning

confidence: 99%

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Sustained local application of epidermal growth factor to accelerate reepithelialization of tracheal grafts

Zhao

Han

Liang

et al. 2010

The Journal of Thoracic and Cardiovascular Surgery

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Sustained local application of epidermal growth factor to accelerate reepithelialization of tracheal grafts

Zhao

Han

Liang

et al. 2010

The Journal of Thoracic and Cardiovascular Surgery

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“… 15 For example, BMP-2 is efficient at stimulating bone or cartilage regeneration in tracheal grafts. 186 Stromal cell-derived factor 1 (SDF-1) and platelet-derived growth factor-BB could enhance endogenous cell recruitment and cartilage matrix formation. 187 Recombinant human transglutaminase-4 enhances rabbit cartilage regeneration of the SMSCs encapsulated in HA/collagen/fibrinogen composite hydrogel.…”

Section: Articulate Cartilage Defects Therapeutic Strategiesmentioning

confidence: 99%

Regeneration of articular cartilage defects: Therapeutic strategies and perspectives

Guo

Ling

et al. 2023

J Tissue Eng

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Articular cartilage (AC), a bone-to-bone protective device made of up to 80% water and populated by only one cell type (i.e. chondrocyte), has limited capacity for regeneration and self-repair after being damaged because of its low cell density, alymphatic and avascular nature. Resulting repair of cartilage defects, such as osteoarthritis (OA), is highly challenging in clinical treatment. Fortunately, the development of tissue engineering provides a promising method for growing cells in cartilage regeneration and repair by using hydrogels or the porous scaffolds. In this paper, we review the therapeutic strategies for AC defects, including current treatment methods, engineering/regenerative strategies, recent advances in biomaterials, and present emphasize on the perspectives of gene regulation and therapy of noncoding RNAs (ncRNAs), such as circular RNA (circRNA) and microRNA (miRNA).

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“…Nevertheless, better results are obtained when BMSCs are delivered along with BMP-2 [ 251 , 273 , 274 , 283 ]. Another challenge is that BMP-2 has been shown to boost growth of surrounding bone tissues, such as cartilage and tendon [ 311 , 312 , 313 , 314 ]. As a result, control release of BMP-2 is desired to eliminate untargeted tissue growth that may interrupt bone regeneration and cause cosmetic deformities.…”

Section: Protein-based Therapy: Current Approaches and Potential Therapymentioning

confidence: 99%

Craniofacial Bone Tissue Engineering: Current Approaches and Potential Therapy

Aghali

2021

Cells

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Craniofacial bone defects can result from various disorders, including congenital malformations, tumor resection, infection, severe trauma, and accidents. Successfully regenerating cranial defects is an integral step to restore craniofacial function. However, challenges managing and controlling new bone tissue formation remain. Current advances in tissue engineering and regenerative medicine use innovative techniques to address these challenges. The use of biomaterials, stromal cells, and growth factors have demonstrated promising outcomes in vitro and in vivo. Natural and synthetic bone grafts combined with Mesenchymal Stromal Cells (MSCs) and growth factors have shown encouraging results in regenerating critical-size cranial defects. One of prevalent growth factors is Bone Morphogenetic Protein-2 (BMP-2). BMP-2 is defined as a gold standard growth factor that enhances new bone formation in vitro and in vivo. Recently, emerging evidence suggested that Megakaryocytes (MKs), induced by Thrombopoietin (TPO), show an increase in osteoblast proliferation in vitro and bone mass in vivo. Furthermore, a co-culture study shows mature MKs enhance MSC survival rate while maintaining their phenotype. Therefore, MKs can provide an insight as a potential therapy offering a safe and effective approach to regenerating critical-size cranial defects.

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Bone Morphogenetic Protein-2 Stimulation of Cartilage Regeneration in Canine Tracheal Graft

Cited by 5 publications

References 29 publications

Sustained local application of epidermal growth factor to accelerate reepithelialization of tracheal grafts

Sustained local application of epidermal growth factor to accelerate reepithelialization of tracheal grafts

Regeneration of articular cartilage defects: Therapeutic strategies and perspectives

Craniofacial Bone Tissue Engineering: Current Approaches and Potential Therapy

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