Bone Regulates Glucose Metabolism as an Endocrine Organ through Osteocalcin

Shao, Jian Yong; Zhi, Wang; Yang, Tieyi; Ying, Hui; Zhang, Yan; Shuyi, Liu

doi:10.1155/2015/967673

Cited by 46 publications

(34 citation statements)

References 73 publications

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“…Correspondingly, the cells from healthy donor that exhibited low BSP expression had inferior cell proliferation ability. The OCN was shown to stimulate osteoblast differentiation and osteocyte maturation participating in bone matrix mineralisation (Shao et al, ). The FAM83H mutant cells showed reduced OCN expression while maintained mineralisation ability.…”

Section: Discussionmentioning

confidence: 99%

Amelogenesis imperfecta: A novel FAM83H mutation and characteristics of periodontal ligament cells

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Amelogenesis imperfecta: A novel FAM83H mutation and characteristics of periodontal ligament cells

et al. 2018

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“…On the other hand, insulin, insulin-like growth factor type 1 (IGF1) and incretin hormones have a role in regulating bone homeostasis [2]. The binding of insulin to specific receptors on osteoblast exerts anabolic effects, favoring survival, proliferation and differentiation of osteoblasts [3,8]. More importantly, however, is the mechanism for promoting bone resorption insulin-induced by decreasing the expression of osteoprotegerin (OPG) in the osteoblast favoring the osteoclasts function [1,7,8].…”

Section: Introductionmentioning

confidence: 99%

“…The binding of insulin to specific receptors on osteoblast exerts anabolic effects, favoring survival, proliferation and differentiation of osteoblasts [3,8]. More importantly, however, is the mechanism for promoting bone resorption insulin-induced by decreasing the expression of osteoprotegerin (OPG) in the osteoblast favoring the osteoclasts function [1,7,8]. During bone resorption, osteoclasts generate an acidic pH at resorption lacunae level, making it a suitable environment for stored osteocalcin decarboxylation in the bone matrix, allowing it to enter the systemic circulation [3,4].…”

Section: Introductionmentioning

confidence: 99%

Metabolic and bone profile in postmenopausal women with and without type 2 diabetes: a cross-sectional study

Dumitru

Cârșote

Cocolos

et al. 2019

Romanian Journal of Internal Medicine

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Introduction. Current studies support the implication of metabolic changes associated with type 2 diabetes in altering bone metabolism, structure and resistance. Objective. We conducted a cross-sectional study on postmenopausal women aimed to analyze the differences in metabolic and bone profile in patients with and without type 2 diabetes Methods. We analyzed the metabolic and bone profile in postmenopausal women with and without type 2 diabetes (T2DM). Clinical, metabolic, hormonal parameters, along with lumbar, hip and femoral bone mineral density (BMD) and trabecular bone score (TBS) were evaluated. Results. 56 women with T2DM(63.57±8.97 years) and 83 non-T2DM (60.21±8.77 years) were included. T2DM patients presented a higher value of body mass index (BMI) and BMD vs. control group (p = 0.001; p = 0.03-lumbar level, p = 0.07-femoral neck and p = 0.001-total hip). Also, BMI correlated positively with lumbar-BMD and glycated hemoglobin (HbA1c) (r = 0.348, p = 0.01; r = 0.269, p = 0.04), correlation maintained even after age and estimated glomerular filtration rate (eGFR) adjustment (r = 0.383, p = 0.005; r = 0.237, p = 0.08). Diabetic patients recorded lower levels of 25(OH)D(p = 0.05), bone markers (p ≤ 0.05) and TBS(p = 0.07). For the entire patient group we found a negative correlation between HbA1c level and bone markers: r = -0.358, p = 0.0005-osteocalcin, r = -0.40, p = 0.0005-P1NP, r = -0.258, p = 0.005-crosslaps. Conclusions. Our results indicate the presence of altered bone microarchitecture in T2DZ patients according to the TBS score, combined with lower levels of bone markers, with a statistically significant negative correlation between HbA1c level and bone markers.

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“…Animal's models have shown that the lack of osteoblasts has been associated not only to alterations on bone density but also to impaired glucose metabolism, such as high blood glucose, low insulin secretion, and insulin resistance The administration of OC can restore glucose and insulin level in circulation but only partially the insulin sensitivity [23][24][25]. In our study, we also observed an association between OC levels and Beta-CTx with insulin resistance, as it has been reported in obese subjects [17,22].…”

Section: Discussionmentioning

confidence: 99%

Serum Concentrations of Osteocalcin (OC) and Beta-Cross Laps (Beta-CTx) and Insulin Resistance in Morbid Obese Women with and without DM2

Arrieta¹,

Iglesias²,

Piñera³

et al. 2017

Glob J Obes Diabetes Metab Syndr

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Aim:The present study was intended to establish the role of bone in grade III obese women with and without type 2 diabetes mellitus (T2DM). Material & Methods:Serum osteocalcin (OC), Beta Cross-Laps (Beta-CTx), parathormone (PTH) separar and y 25-hydroxyvitamin D (25OHD) concentrations were measured in 48 morbid obesity women (11 with T2DM and 37 control group). Insulin resistance and insulin secretion was assessed by measuring the HOMA-IR and the HOMAβ index and its association with OC and Beta-CTx.Results: Serum OC was signifi cant lower in the diabetic group compared with non-diabetic patients 15.4 ± 3.6 ng/ml vs 22.1 ± 3.5 ng/ml, p<0.001 without signifi cant differences in Beta-CTx (0.24 ± 0.1 vs 0.31 ± 0.2 ng/ml, ns). Both bone biomarkers, OC and Beta-CTx, showed a positive correlation (r=0.76; p<0.01) in the whole group subjects and in the control group (r=0.80, p<0.00), but no in the T2DM group (r=0.50, p ns). In the whole group of patients, OC correlated signifi cantly with HOMA-IR (r=0.36; p<0.01) and HOMA-ß (r=0.36, p<0.01). Beta-CTx also correlated with HOMA-IR (r= 0.40, p<0.01) and HOMA-ß (r= 0.41, p<0.001. OC also signifi cantly correlated with HOMA-IR (r=0.41, p<0.01) in non-diabetic patients and almost reached statistical signifi cance with HOMA-ß (r=0.32, p=0.053), but was not signifi cantly correlated with HOMA-ß (r= -0.53, ns) and with HOMA-IR index (r=0.52, ns) in the T2DM group. When we performed the multivariate logistic regression the serum level of OC was the only covariate found signifi cantly with DM2 with a coefi cient -6.65 , (95% CI, -12.75049 -.5674469 ); p = 0.03). Both groups showed secondary hyperparathyroidism (T2DM, 78.4 ± 19.4 pg/ml vs non-diabetic group, 75.4 ± 35.6 pg/ ml; ns). The majority of the patients showed 25OHD defi ciency 62.5%, followed by 25OHD insuffi ciency 27.1% and normal 25OHD levels in only 10.4%. The 25OHD defi ciency was present in both study groups (T2DM patients, 18.3 ± 7.4 pg/ml and nondiabetic group, 19.7 ± 9.6 pg/ml; ns). Conclusion: OC and Beta-CTx could play a role in glucose metabolism and insulin resistance. Serum OC concentrations are signifi cantly reduced in T2DM morbidily obese women compared with nondiabetic group, and add new evidence on the possible role of bone as an endocrine organ with metabolic implications specially the levels of OC. Citation: Arrieta F, Iglesias P, Piñera M, Arrieta A,Quiñones J, et al. (2017) Serum Concentrations of Osteocalcin (OC) and Beta-Cross Laps (Beta-CTx) and Insulin Resistance in Morbid Obese Women with and without DM2. Glob J Obes Diabetes Metab Syndr 4(3): 072-076.

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Bone Regulates Glucose Metabolism as an Endocrine Organ through Osteocalcin

Cited by 46 publications

References 73 publications

Amelogenesis imperfecta: A novel FAM83H mutation and characteristics of periodontal ligament cells

Amelogenesis imperfecta: A novel FAM83H mutation and characteristics of periodontal ligament cells

Metabolic and bone profile in postmenopausal women with and without type 2 diabetes: a cross-sectional study

Serum Concentrations of Osteocalcin (OC) and Beta-Cross Laps (Beta-CTx) and Insulin Resistance in Morbid Obese Women with and without DM2

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