Bone repair in rats treated with sodic diclofenac and calcitonin&lt;A NAME="volta1"&gt;&lt;/A&gt;

Sassioto, Maria Cristina Pita; Inouye, Celso Massaschi; Aydos, Ricardo Dutra; Figueiredo, Arthur Silveira de

doi:10.1590/s0102-86502006001000010

Cited by 9 publications

(6 citation statements)

References 15 publications

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“…Three important outcomes commonly used to assess bone healing were analyzed: biomechanical properties (maximum force to break, stiffness, and work to failure), micro CT, and histomorphometric measurements. NSAID administration had a negative effect on the biomechanical properties in different animal models of the included studies (10,12,18,19,47,(50)(51)(52)(53)(54)(55)(56)(57)(58). However, the results for histomorphometric assessments did not show a difference (Tables 3). Depending on the type of NSAID, they are known to inhibit both COX isoforms.…”

Section: Discussionmentioning

confidence: 92%

Non-Steroidal Anti-Inflammatory Drugs and Bone Healing in Animal Models – A Systematic Review and Meta-analysis

Al-Waeli

Reboucas²,

Mansour

et al. 2020

Preprint

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Background: Non-steroidal anti-inflammatory drugs (NSAID) have excellent anti-inflammatory and analgesic properties and are extensively used to treat post-traumatic or surgical musculoskeletal pain. Although an extensive literature exists on the administration of NSAID on animal bone healing, no systematic review and meta-analysis have yet been conducted to on the subject. Such work is important as it can identify the key histomorphometric and biomechanics characteristics during the process of fracture healing and provide comparative information regarding different factors that may affect this process after NSAID administration.Methods: We performed a systematic review and meta-analysis of animal studies to estimate the effect of NSAID administration after bone fracture on healing outcomes. We searched eight databases without limiting the search to starting date up to August 1, 2017 for articles on fractured bone healing in animal models in which NSAID were administered.Results: Out of 5,818 articles screened, 45 were included and three common bone healing outcomes were analysed: biomechanical properties (maximum force to break, stiffness, and work-to-failure), micro-computed tomography (µ-CT), and histomorphometric measurements. The studies were generally of low-quality scores because crucial information, especially concerningrandomization, blinding, and allocation concealment, was poorly reported. Our results show that the negative effects of NSAID after bone fracture on certain biomechanical properties of the healing bones was not statistically significant in mice compared with other animals, in females compared with males, and in younger compared with older animals.Conclusion: The findings suggest that NSAID should be administered with caution in patients with bone fractures or in those who undergo certain orthopedic surgical procedures until prospective human clinical studies can be conducted.Systematic review registration: the protocol published and registered in SYstematic Review Center for Laboratory animal Experimentation (SYRCLE) in 2017, https://www.radboudumc.nl/getmedia/757ec408-7a9e-4635-8233-ae951effea54/Non-Steroidal-Anti-inflammatory-Drugs-and-bone-healing-in-animal-Models-Systematic-Review-and-Meta-Analysis.aspx

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Section: Discussionmentioning

confidence: 92%

Non-Steroidal Anti-Inflammatory Drugs and Bone Healing in Animal Models – A Systematic Review and Meta-analysis

Al-Waeli

Reboucas²,

Mansour

et al. 2020

Preprint

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“…The most consistently reported outcome measure was percentage bone formation in the category of human proteins and hormones ( Fig 3 [ 25 , 28 , 32 , 36 , 39 – 58 ]). Study findings across all categories for bone formation, bone volume and bone density are shown in Fig 4 , [ 23 , 47 , 51 , 53 , 54 , 57 , 59 – 77 ], Fig 5 [ 29 , 37 , 38 , 78 – 86 ] and Fig 6 [ 87 – 91 ]). Table 4 ([ 92 – 105 ]) shows the findings for the pharmaceutical therapies that could not be represented in forest plots, with findings for the remaining categories available as supporting information ( S4 , S5 , S6 , S7 , S8 , S9 , S10 and S11 Tables).…”

Section: Resultsmentioning

confidence: 99%

Preclinical therapies to prevent or treat fracture non-union: A systematic review

Bennett¹,

Stewart

Dretzke

et al. 2018

PLoS ONE

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BackgroundNon-union affects up to 10% of fractures and is associated with substantial morbidity. There is currently no single effective therapy for the treatment or prevention of non-union. Potential treatments are currently selected for clinical trials based on results from limited animal studies, with no attempt to compare results between therapies to determine which have the greatest potential to treat non-union.AimThe aim of this systematic review was to define the range of therapies under investigation at the preclinical stage for the prevention or treatment of fracture non-union. Additionally, through meta-analysis, it aimed to identify the most promising therapies for progression to clinical investigation.MethodsMEDLINE and Embase were searched from 1St January 2004 to 10th April 2017 for controlled trials evaluating an intervention to prevent or treat fracture non-union. Data regarding the model used, study intervention and outcome measures were extracted, and risk of bias assessed.ResultsOf 5,171 records identified, 197 papers describing 204 therapies were included. Of these, the majority were only evaluated once (179/204, 88%), with chitosan tested most commonly (6/204, 3%). Substantial variation existed in model design, length of survival and duration of treatment, with results poorly reported. These factors, as well as a lack of consistently used objective outcome measures, precluded meta-analysis.ConclusionThis review highlights the variability and poor methodological reporting of current non-union research. The authors call for a consensus on the standardisation of animal models investigating non-union, and suggest journals apply stringent criteria when considering animal work for publication.

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“…The forest plot displays the standard mean differences (SMDs) Hedges' g, 95% confidence interval. The diamond indicates the global (overall) estimation and its 95% confidence interval NSAID administration had a negative effect on the biomechanical properties in different animal models of the included studies [10,12,18,19,48,[51][52][53][54][55][56][57][58][59]. However, the results for histomorphometric assessments did not show a difference (Table 3).…”

Section: Discussionmentioning

confidence: 98%

Non-steroidal anti-inflammatory drugs and bone healing in animal models—a systematic review and meta-analysis

et al. 2021

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Background Non-steroidal anti-inflammatory drugs (NSAID) have excellent anti-inflammatory and analgesic properties and are extensively used to treat post-traumatic or surgical musculoskeletal pain. Although an extensive literature exists on the administration of NSAID on animal bone healing, no systematic review and meta-analysis of animal studies that investigate the effect of NSAID administration on bone fracture healing. Objective of this study is to conduct a systematic review and meta-analysis to estimate the effect of NSAIDs administration on bone healing biomechanical and histomorphometric measurements in different animal models after bone fracture surgery. Methods We performed a systematic review and meta-analysis of animal studies to estimate the effect of NSAID administration after bone fracture on healing outcomes. We searched eight databases without limiting the search to starting date up to 1 February 2021 for articles on fractured bone healing in animal models in which NSAID were administered. Results Out of 6732 articles screened, 47 were included and 3 common bone healing outcomes were analysed: biomechanical properties (maximum force to break, stiffness, and work-to-failure), micro-computed tomography (μ-CT), and histomorphometric measurements. The studies were generally of low-quality scores because crucial information, especially concerning randomization, blinding, and allocation concealment, was poorly reported. Our results show that the negative effects of NSAID after bone fracture on certain biomechanical properties of the healing bones was not statistically significant in mice compared with other animals, in females compared with males, and in younger compared with older animals. Conclusion The findings demonstrated that NSAIDs administration decreased the biomechanical properties of healing bones after fracture surgery in comparison to the control group. Moreover, different effect on certain outcomes was detected among different sites, sex of the animals, and the time of assessment. Trial registration Protocol published and registered in SYstematic Review Center for Laboratory animal Experimentation (SYRCLE) in 2017, https://www.radboudumc.nl/getmedia/757ec408-7a9e-4635-8233-ae951effea54/Non-Steroidal-Anti-inflammatory-Drugs-and-bone-healing-in-animal-Models-Systematic-Review-and-Meta-Analysis.aspx

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Bone repair in rats treated with sodic diclofenac and calcitonin<A NAME="volta1"></A>

Cited by 9 publications

References 15 publications

Non-Steroidal Anti-Inflammatory Drugs and Bone Healing in Animal Models – A Systematic Review and Meta-analysis

Non-Steroidal Anti-Inflammatory Drugs and Bone Healing in Animal Models – A Systematic Review and Meta-analysis

Preclinical therapies to prevent or treat fracture non-union: A systematic review

Non-steroidal anti-inflammatory drugs and bone healing in animal models—a systematic review and meta-analysis

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