Bone repair of defects filled with a phosphocalcic hydraulic cement: an in vivo study

Abstract

A quickly setting calcium phosphate-based hydraulic cement mixed with particles of tricalcium phosphate (TCP) ceramic was implanted in 56 metaphysial defects made in the long bones of ten adult mongrel dogs. Microradiography, histology and scanning electron microscopy (SEM) demonstrated the slow resorption of the cement and the bony incorporation of the calcium phosphate ceramic particles which were consistently embedded in bone. The original structural pattern of the bone tended to be restored 7 months after implantation. The cement did not hinder the incorporation of the calcium phosphate ceramic particles, neither did it elicit any inflammatory or foreign-body response. The cement was easily shaped and allowed a perfect filling of any defect, resulting in close contact of the whole implant surface with the host bone at the time of surgery, associated with appreciable mechanical strength. Most of the practical problems associated with the use of calcium phosphate ceramics in the repair of bone defects could be overcome with the cement.

Radiographic Evaluations of the Tetra-Calcium Phosphate and Diacalcium Phosphate with Bone Plate in Osseo-Integration of Bone Repair in Rabbit

“…The initial attachment and subsequent proliferation of osteogenic cells, as well as their ability to form bone are the most important factors affecting the success of a bone implant [7,8] . Application of these cements with correct biological activity the major changes revealed no sign of infection on the edges of each defect and There was no dislocation of implants in all groups [10][11] . Both groups permitted stabilization of the defected bones and maintenance of correct position.…”

Cimento de aluminato de cálcio: uso em defeitos ósseos induzidos em fêmur de coelhos

“…É sabido que a melhor escolha recai sobre o tecido ósseo autógeno, pois possui células vivas que estimulam a osteogênese. No entanto, suas desvantagens incluem o aumento do tempo operatório, dificuldade de conformação exata ao defeito e quantidade insuficiente de osso para a restauração (Constantino et al, 1991;Munting et al, 1993;Kurashina et al, 1998;Weinfeld, 1999).…”

Fiber-enriched calcium phosphate cement implanted in the femur of rats: a histological evaluation.

“…One example is the research on calcium phosphate cements, which have been extensively studied in the past years due to their potential suitability for biomedical applications 4,5 . Resistant, biocompatible materials such as calcium phosphate are extremely valuable; autografts, which are still widely employed with the aim of preventing an adverse immune reaction, have limitations associated with the location and size of bone defect, in addition to disadvantages such as the need for a second surgical intervention to remove the graft, postoperative complications, increased surgical time, difficulty in shaping the graft in the adequate form, and in some cases, unavailability of the necessary amount of bone 6,7 .…”