Bone resorption acceleration and calcium reabsorption impairment in a Thai population with high cadmium exposure

Nambunmee, Kowit; Honda, R.; Nishijo, Muneko; Swaddiwudhipong, Witaya; Nakagawa, Hideaki; Ruangyuttikarn, Werawan

doi:10.3109/15376510903452941

Cited by 31 publications

(24 citation statements)

References 30 publications

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“…This is supported by a study of residents in Thailand with elevated urinary Cd, where the fractional excretion of calcium increased with rising cadmium exposure (urinary Cd) especially in women [28]. In that study, there was also a positive correlation between fractional calcium excretion and the excretion of bone resorption markers, and the levels of those markers were significantly higher in women.…”

Section: Discussionmentioning

confidence: 65%

Kidney cadmium levels and associations with urinary calcium and bone mineral density: a cross-sectional study in Sweden

et al. 2013

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BackgroundCadmium (Cd) can cause renal damage and osteoporosis after high-level exposure. Recently such effects, including increased urinary excretion of calcium, have been shown also at low-level exposure, as measured by Cd in blood or urine. However, associations with kidney Cd have not been examined. The aim of this study was to explore the relation between kidney Cd and urinary calcium excretion, or bone mineral density.MethodsCd was determined in kidney cortex biopsies from 109 living kidney donors. Serum was analyzed for ionized calcium, parathyroid hormone and vitamin D. Calcium was analyzed in overnight and 24-hour urine samples. Bone mineral density was measured in a subgroup of 67 donors. Associations between single variables were assessed by Spearman and Pearson correlation coefficients. Differences between independent groups were compared using Student’s t-test. For related samples, paired t-test was applied. Associations between urinary calcium and kidney Cd, ionized serum calcium, serum parathyroid hormone, inactive and active vitamin D and background variables were assessed using multiple linear regression and logistic regression.ResultsIn spite of relatively low kidney Cd levels (median 13 μg/g, range 1.5-55 μg/g) kidney Cd and urinary calcium were positively associated, mainly caused by an association in women. Donors with kidney Cd above the median (subgroup mean 23 μg/g) had significantly higher excretion of urinary calcium normalized for creatinine than those below the median (subgroup mean 7.3 μg/g). In women, also the excretion of Ca per hour was higher in those with high kidney Cd (24 hour sample mean 0.21 vs. 0.15 mmol/h; overnight sample 0.16 vs. 0.11 mmol/h). There were negative associations between kidney Cd and bone mineral density, most of which, however, disappeared in multivariate analyses.ConclusionsThis study provides support for an association between kidney Cd levels and urinary calcium excretion in women, but not in men. The results strengthen the case for preventive measures against Cd pollution.

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Section: Discussionmentioning

confidence: 65%

Kidney cadmium levels and associations with urinary calcium and bone mineral density: a cross-sectional study in Sweden

et al. 2013

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“…Increased urinary excretion of Ca was reported to be associated with increased Cd in the kidney in women [18], suggesting Cd exposure may influence bone metabolism mainly through increased Ca excretion into the urine in women. In residents aged ≥ 50 years in the same population, Nambunmee et al [10] reported that FECa, which increased with increased urinary Cd, was closely associated with an increase in urinary NTx, particularly in women. In the female participants in the current study, the prevalence of bone metabolic disorders based on a urinary NTx level ≥ 89.0 (nM BCE/mM Crea) was high, more than 25%, but only FECa was significantly associated with the prevalence of bone metabolic disorders.…”

Section: Discussionmentioning

confidence: 99%

“…Swaddiwudhipong et al [9] reported that increased serum creatinine (Crea) and decreased glomerular filtration rate was associated with increased urinary Cd in inhabitants in the same contaminated area in Mae Sot with urinary Cd ≥ 5 μg/g Crea. In our own previous research, we found an imbalance in Ca reabsorption because of remarkable renal tubular dysfunction that leads to increased bone resorption markers in residents in Mae Sot aged ≥50 years old, particularly female residents including premenopausal women [10]. …”

Section: Introductionmentioning

confidence: 99%

Gender-Specific Impact of Cadmium Exposure on Bone Metabolism in Older People Living in a Cadmium-Polluted Area in Thailand

Nishijo

Nambunmee

Suvagandha

et al. 2017

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To elucidate the influence of cadmium exposure on bone metabolism, associations between urinary/blood cadmium and bone resorption/formation markers were investigated in older cadmium exposed men and women. Increased urinary cross-linked N-telopeptide of type I collagen (NTx), a bone resorption marker, was found to be associated with increased levels of parathyroid hormone, fractional excretion of calcium, and urinary/blood cadmium after adjusting for confounding factors in men. In women, urinary NTx was significantly associated with only urinary cadmium and a strong relationship with increased fractional excretion of calcium. Risk for bone metabolic disorders, indicated by high urinary NTx, significantly increased in men with blood cadmium ≥ 10 μg/L or urinary cadmium ≥ 10 μg/g creatinine. Increased osteocalcin level was significantly associated with increased blood cadmium in men. In conclusion, cadmium exposure appeared to have an influence on bone remodeling both bone resorption and formation in this population of older Thai men, and blood cadmium was more closely associated with bone metabolism than urinary cadmium.

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“…The study area and subjects have been previously described and extensively characterized (Nambunmee et al, 2010; Ruangyuttikarn et al, 2013). Briefly, the study participants consisted of 169 residents living in Mae Ku, Phra Thad Padang, and Mae Tao, known polluted areas of Mae Sot, and 100 participants living the Mae Kasa subdistrict, a non-contaminated area of Mae Sot (Simmons et al, 2005).…”

Section: Methodsmentioning

confidence: 99%

“…These areas are all rural, with similar socioeconomic environments. Subjects from polluted areas aged ≥ 40 years and with urinary Cd levels ≥5 μg/g creatinine in the 2007 survey were included in this study (Nambunmee et al, 2010). Exposed residents were 5-year age-matched to residents from the Mae Kasa subdistrict.…”

Section: Methodsmentioning

confidence: 99%

DNA methylation is differentially associated with environmental cadmium exposure based on sex and smoking status

et al. 2016

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The adverse health effects of cadmium (Cd) are well known in human populations; however, much of what is known about biological mechanisms of Cd comes from in vitro and animal studies. The adverse health outcomes due to high levels of Cd exposure in the population of Mae Sot, Thailand have been extensively characterized. Here, for the first time, this population is being studied in an epigenetic context. The objective of this study was to characterize the association between DNA methylation markers and Cd exposure, taking into account sex and smoking differences, in an adult population at an increased risk of experiencing adverse health outcomes from high body burden of Cd. One hundred and sixty-nine residents from known exposure areas of Mae Sot, Thailand and one hundred residents from non-exposed areas nearby were surveyed in 2012. Urine and blood samples were collected for measurement of urinary Cd (UCd) and DNA methylation of Cd-related markers (DNMT3B, MGMT, LINE-1, MT2A). UCd levels were 7 times higher in the exposed compared to the unexposed populations (exposed median: 7.4 μg/L, unexposed median: 1.0 μg/L, p <0.001). MGMT hypomethylation was associated with increasing levels of UCd in the total population. Sex-specific associations included MT2A and DNMT3B hypomethylation in women and LINE-1 hypermethylation in men with increasing UCd. Upon subanalysis, these associations separated by smoking status. In summary, environmental Cd exposure is associated with gene-specific DNA methylation in a sex and smoking dependent manner.

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Bone resorption acceleration and calcium reabsorption impairment in a Thai population with high cadmium exposure

Cited by 31 publications

References 30 publications

Kidney cadmium levels and associations with urinary calcium and bone mineral density: a cross-sectional study in Sweden

Kidney cadmium levels and associations with urinary calcium and bone mineral density: a cross-sectional study in Sweden

Gender-Specific Impact of Cadmium Exposure on Bone Metabolism in Older People Living in a Cadmium-Polluted Area in Thailand

DNA methylation is differentially associated with environmental cadmium exposure based on sex and smoking status

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