Bone response to calcium phosphate-coated and bisphosphonate-immobilized titanium implants

Yoshinari, Masao; Oda, Yutaka; Inoue, Takashi; Matsuzaka, Kenichi; Shimono, Masaki

doi:10.1016/s0142-9612(01)00415-x

Cited by 155 publications

(128 citation statements)

References 28 publications

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“…Bisphosphates are antiresorptive agents that have beneficial effects for the patients on preventing further bone loss, and their effects on increasing the bone mass is modest (Kwak et al, 2009, Yoshinari et al, 2002. It has been shown that bisphosphonate incorporated on to titanium implants increased bone density locally in the peri-implant region (Josse et al, 2005) with the effect of the antiresorptive drug limited to the vicinity of the implant.…”

Section: Bisphosphonatesmentioning

confidence: 99%

Dental Implant Surface Enhancement and Osseointegration

Anil¹,

Anand²,

Alghamdi³

et al. 2011

Implant Dentistry - A Rapidly Evolving Practice

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Section: Bisphosphonatesmentioning

confidence: 99%

Dental Implant Surface Enhancement and Osseointegration

Anil¹,

Anand²,

Alghamdi³

et al. 2011

Implant Dentistry - A Rapidly Evolving Practice

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“…It has been reported that the crystalline calcium phosphate coating film formed by sputtering methods enhanced the biocompatibility of titanium materials with bones. [6][7][8][9][10] In the present study, the application of sputtered ACP films as coatings on titanium implants was suggested to be effective for their rapid and strong fixation with bones. The low processing temperature required in the sputtering process of ACP films could prove as an advantage for its coating on implants made of -type titanium alloys compared with other coating methods having high-temperature processes or post heat treatments such as sol-gel coating and NaOH treatment method, because the microstructure of -type titanium alloys change due to the high processing temperature during coating.…”

Section: In Vitro Evaluationmentioning

confidence: 81%

“…In addition to that, thin calcium phosphate films fabricated with RF magnetron sputtering might be able to maintain the roughness of titanium implants such as dental implants. Although in vivo evaluations of RF-magnetron-sputtered calcium phosphate films on titanium have been studied, [6][7][8][9][10] the effects of the phase and crystallinity of calcium phosphate films on their performance have not been understood in detail. The stability of calcium phosphate materials is regarded to be composition-and structure-dependent.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Calcium Phosphate Coating Films on Titanium Fabricated Using RF Magnetron Sputtering

et al. 2007

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Calcium phosphate coating films fabricated on commercially pure titanium (CP-Ti) substrates using radiofrequency (RF) magnetron sputtering were evaluated in vivo and in vitro for investigating their applications in dental and medical implants. For the in vitro evaluations of the calcium phosphate coating films, the bonding strength and alkaline phosphatase (ALP) activity were examined. The bonding strength of the coating films to a polished titanium plate exceeded 60 MPa. When compared with an uncoated titanium plate, the increase in the ALP activity of SaOS-2 cells (a well-characterized osteosarcoma human cell line exhibiting osteoblast-like properties) on a titanium plate coated with a calcium phosphate film was confirmed by a culture test. Titanium cylinders coated with an amorphous calcium phosphate film were implanted into the mandibles of beagle dogs. The percentage of bone-implant contact in coated titanium was greater than that in uncoated titanium.

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“…In vivo studies especially these two materials are known for their good osteoconductivity (for the early stage of osteogenesis). They enable direct binding to bone tissue in vivo [1,19]. From this point of view, the second group was selected as sand blasted and then acid etched which decreases the shot particle geometry sharpness on the titanium implant surfaces.…”

Section: Implant Specimensmentioning

confidence: 99%

Measurement and image processing evaluation of surface modifications of dental implants G4 pure titanium created by different techniques

Bulutsuz¹,

Demircioglu²,

Böğrekçi³

et al. 2015

AIP Conference Proceedings

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Abstract. Foreign substances and organic tissue interaction placed into the jaw in order to eliminate tooth loss involves a highly complex process. Many biological reactions take place as well as the biomechanical forces that influence this formation. Osseointegration denotes to the direct structural and functional association between the living bone and the load-bearing artificial implant's surface. Taking into consideration of the requirements in the manufacturing processes of the implants, surface characterizations with high precise measurement techniques are investigated and thus long-term success of dental implant is emphasized on the importance of these processes in this study. In this research, the detailed surface characterization was performed to identify the dependence of the manufacturing techniques on the surface properties by using the image processing methods and using the scanning electron microscope (SEM) for morphological properties in 3D and Taylor Hobson stylus profilometer for roughness properties in 2D. Three implant surfaces fabricated by different manufacturing techniques were inspected, and a machined surface was included into the study as a reference specimen. The results indicated that different surface treatments were strongly influenced surface morphology. Thus 2D and 3D precise inspection techniques were highlighted on the importance for surface characterization. Different image analyses techniques such as Dark-light technique were used to verify the surface measurement results. The computational phase was performed using image processing toolbox in Matlab with precise evaluation of the roughness for the implant surfaces. The relationship between the number of black and white pixels and surface roughness is presented. FFT image processing and analyses results explicitly imply that the technique is useful in the determination of surface roughness. The results showed that the number of black pixels in the image increases with increase in surface roughness.

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Bone response to calcium phosphate-coated and bisphosphonate-immobilized titanium implants

Cited by 155 publications

References 28 publications

Dental Implant Surface Enhancement and Osseointegration

Dental Implant Surface Enhancement and Osseointegration

Evaluation of Calcium Phosphate Coating Films on Titanium Fabricated Using RF Magnetron Sputtering

Measurement and image processing evaluation of surface modifications of dental implants G4 pure titanium created by different techniques

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