Bone stimulation for fracture healing: What′s all the fuss?

Victoria, Galkowski; Petrisor, Brad; Drew, Brian; Dick, D J

doi:10.4103/0019-5413.50844

Cited by 118 publications

(92 citation statements)

References 11 publications

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“…In the United States of America it was estimated that in 2009 there were 7.9 million fractures, and these injuries have an important impact on society and the health system 11 . Additionally, 10% of the fractures may have improper healing or fail to heal…”

Section: ■ Introductionmentioning

confidence: 99%

Nandrolone decanoate appears to increase bone callus formation in young adult rats after a complete femoral fracture

Guimarães

Butezloff²,

Zamarioli³

et al. 2017

Acta Cir. Bras.

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Nandrolone decanoate appears to increase bone callus formation in young adult rats after a complete femoral fracture 1 AbstractPurpose: To evaluate the influence of nandrolone decanoate on fracture healing and bone quality in normal rats. Methods: Male rats were assigned to four groups (n=28/group): Control group consisting of animals without any intervention, Nandrolone decanoate (DN) group consisting of animals that received intramuscular injection of nandrolone decanoate, Fracture group consisting of animals with a fracture at the mid-diaphysis of the femur, and Fracture and nandrolone decanoate group consisting of animals with a femur fracture and treatment with nandrolone decanoate. Fractures were created at the mid-diaphysis of the right femur by a blunt trauma and internally fixed using an intramedullary steel wire. The DN was injected intramuscularly twice per week (10 mg/kg of body mass). The femurs were measured and evaluated by densitometry and mechanical resistance after animal euthanasia. The newly formed bone and collagen type I levels were quantified in the callus. Results:The treated animals had longer femurs after 28 days. The quality of the intact bone was not significantly different between groups. The bone callus did show a larger mass in the treated rats. Conclusion:The administration of nandrolone decanoate did not affect the quality of the intact bone, but might have enhanced the bone callus formation.

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Section: ■ Introductionmentioning

confidence: 99%

Nandrolone decanoate appears to increase bone callus formation in young adult rats after a complete femoral fracture

Guimarães

Butezloff²,

Zamarioli³

et al. 2017

Acta Cir. Bras.

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“…As the mean amount of mad honey consumed for therapeutic purposes by a 70-kg adult is 4-6 g/day (1 teaspoonful), each rat in the mad honey groups (15-and 30-day) received a mean 80 mg/kg mad honey per day by the orogastric route throughout the study period [1]. Mad honey was obtained from a sample that caused a clinical case of toxicity after consumption; it was confirmed to have originated from a Rhododendron-containing area of the Black Sea Region.…”

Section: Treatment Protocolsmentioning

confidence: 99%

“…These have an adverse psychological impact and also result in workforce and economic losses. Various methods of accelerating fracture healing and permitting a return to daily life as early as possible are currently under investigation [1].…”

Section: Introductionmentioning

confidence: 99%

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A Comparison of the Effects of Grayanotoxin-Containing Honey (Mad Honey), Normal Honey, and Propolis on Fracture Healing

et al. 2018

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Objectives: Delayed healing and non-union of fractures have a significant effect upon patient morbidity. Studies have therefore largely concentrated on accelerating fracture healing. This study was intended to compare the effect of “mad honey” and propolis on fracture healing using radiological and histopathological analysis. Subjects and Methods: Femur fracture was surgically performed on 48 rats, followed by fixation. Animals were then divided into 8 groups: 2 control groups (15- and 30-day) and 6 treatment groups (15- and 30-day normal honey, 15- and 30-day “mad honey,” and 15- and 30-day propolis). Rats were sacrificed at the end of these periods, and radiological and histological examinations were performed. Results: Radiological healing in the propolis group after 15-day therapy was statistically better than in the control (p = 0.004) and normal honey (p = 0.006) groups. After 30-day therapy, healing in the propolis group (p = 0.005) and grayanotoxin-containing “mad honey” group (p = 0.007) were significantly better than in the control group. Histologically, there was a statistically significant difference between the 15-day propolis group and the other groups (control, honey, mad honey: p = 0.003, p = 0.003, and p = 0.002, respectively). We also found a statistically significant difference when the 30-day propolis group (p = 0.005) and “mad honey” group (p = 0.007) were compared to the control group. Conclusions: This study shows that grayanotoxin-containing “mad honey” and propolis can accelerate fracture healing.

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“…Fractures, particularly those that had developed into delayed unions or even non-unions, have a substantial clinical, economic, and quality of life impact [75]. Apart from traditional surgical management and rigid fixation (either internal or external), noninvasive PEMFs have already been used effectively in clinics as physical therapy to accelerate and finalize the healing process of a fresh fracture and reactivate the healing process of delayed unions and non-unions for nearly forty years since they were first approved by the US Food and Drug Administration [13, 14].…”

Section: Therapeutic Applications Of Pemfs In Bone Repairmentioning

confidence: 99%

Underlying Signaling Pathways and Therapeutic Applications of Pulsed Electromagnetic Fields in Bone Repair

Yuan

Xin

Jiang

2018

Cell Physiol Biochem

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Pulsed electromagnetic field (PEMF) stimulation, as a prospective, noninvasive, and safe physical therapy strategy to accelerate bone repair has received tremendous attention in recent decades. Physical PEMF stimulation initiates the signaling cascades, which effectively promote osteogenesis and angiogenesis in an orchestrated spatiotemporal manner and ultimately enhance the self-repair capability of bone tissues. Considerable research progresses have been made in exploring the underlying cellular and subcellular mechanisms of PEMF promotion effect in bone repair. Moreover, the promotion effect has shown strikingly positive benefits in the treatment of various skeletal diseases. However, many preclinical and clinical efficacy evaluation studies are still needed to make PEMFs more effective and extensive in clinical application. In this review, we briefly introduce the basic knowledge of PEMFs on bone repair, systematically elaborate several key signaling pathways involved in PEMFs-induced bone repair, and then discuss the therapeutic applications of PEMFs alone or in combination with other available therapies in bone repair, and evaluate the treatment effect by analyzing and summarizing recent literature.

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Bone stimulation for fracture healing: What′s all the fuss?

Cited by 118 publications

References 11 publications

Nandrolone decanoate appears to increase bone callus formation in young adult rats after a complete femoral fracture

Nandrolone decanoate appears to increase bone callus formation in young adult rats after a complete femoral fracture

A Comparison of the Effects of Grayanotoxin-Containing Honey (Mad Honey), Normal Honey, and Propolis on Fracture Healing

Underlying Signaling Pathways and Therapeutic Applications of Pulsed Electromagnetic Fields in Bone Repair

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