Bone substitution in revision hip replacement

Nich, Christophe; Sedel, L.

doi:10.1007/s00264-006-0135-6

Cited by 22 publications

(11 citation statements)

References 32 publications

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“…Among CPCs, HAbased ceramics show excellent osteoconductive and osteointegrative properties 17,19 . Therefore, they have gained great attention in clinical studies [20][21][22][23][24] . However, their relative high Ca/P ratio and crystallinity delay the resorption rate of HA, which typically exhibit a slow resorption at the early stages (weeks 1 to 6) and require long times (months to years) for a complete integration in vivo and subsequent replacement by newly formed bone 17 .…”

Section: Introductionmentioning

confidence: 99%

Full-Field Strain Analysis of Bone–Biomaterial Systems Produced by the Implantation of Osteoregenerative Biomaterials in an Ovine Model

Fernández

Dall’Ara

Bodey

et al. 2019

ACS Biomater. Sci. Eng.

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Osteoregenerative biomaterials for the treatment of bone defects are under much development, with the aim of favoring osteointegration up to complete bone regeneration. A detailed investigation of bone–biomaterial integration is vital to understand and predict the ability of such materials to promote bone formation, preventing further bone damage and supporting load-bearing regions. This study aims to characterize the ex vivo micromechanics and microdamage evolution of bone–biomaterial systems at the tissue level, combining high-resolution synchrotron microcomputed tomography, in situ mechanics and digital volume correlation. Results showed that the main microfailure events were localized close to or within the newly formed bone tissue, in proximity to the bone–biomaterial interface. The apparent nominal compressive load applied to the composite structures resulted in a complex loading scenario, mainly due to the higher heterogeneity but also to the different biomaterial degradation mechanisms. The full-field strain distribution allowed characterization of microdamage initiation and progression. The findings reported in this study provide a deeper insight into bone–biomaterial integration and micromechanics in relation to the osteoregeneration achieved in vivo for a variety of biomaterials. This could ultimately be used to improve bone tissue regeneration strategies.

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Section: Introductionmentioning

confidence: 99%

Full-Field Strain Analysis of Bone–Biomaterial Systems Produced by the Implantation of Osteoregenerative Biomaterials in an Ovine Model

Fernández

Dall’Ara

Bodey

et al. 2019

ACS Biomater. Sci. Eng.

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“…For instance, metaphyseal defects resulting from reduction of tibia compression fracture [30,31] and bone cavities caused by courettage of benign tumour [32,33] can be successfully filled with HA graft. Moreover, osteomyelitic cavities following surgical debridment can be packed with HA blocks combined with antibiotics powder; femoral peri-prosthetic bone defects can be reconstruct using HA granules to limit the amount of allogenic tissue required to increase stability in case of femoral revision arthroplasty [34,35].…”

Section: Discussionmentioning

confidence: 99%

Major bone defect treatment with an osteoconductive bone substitute

2009

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A bone defect can be provoked by several pathological conditions (e.g. bone tumours, infections, major trauma with bone stock loss) or by surgical procedures, required for the appropriate treatment. Surgical techniques currently used for treating bone defects may count on different alternatives, including autologous vascularized bone grafts, homologous bone graft provided by musculoskeletal tissue bank, heterologous bone graft (xenograft), or prostheses, each one of them dealing with both specific advantages and complications and drawbacks. The main concerns related to these techniques respectively are: donor site morbidity and limited available amount; possible immune response and viral transmission; possible animal-derived pathogen transmission and risk of immunogenic rejection; high invasiveness and surgery-related systemic risks, long post-operative. physical recovery and prostheses revision need. Nowadays, an ideal alternative is the use of osteoconductive synthetic bone substitutes. Many synthetic substitutes are available, used either alone or in combination with other bone graft. Synthetic bone graft materials available as alternatives to autogeneous bone include calcium sulphates, special glass ceramics (bioactive glasses) and calcium phosphates (calcium hydroxyapatite, HA; tricalcium phosphate, TCP; and biphasic calcium phosphate, BCP). These materials differ in composition and physical properties fro each other and from bone (De Groot in Bioceramics of calcium phosphate, pp 100-114, 1983; Hench in J Am Ceram Soc 74:1487-1510, 1994; Jarcho in Clin Orthop 157:259-278, 1981; Daculsi et al. in Int Rev Cytol 172:129-191, 1996). Both stoichiometric and non-stoichiometric HA-based substitutes represent the current first choice in orthopedic surgery, in that they provide an osteoconductive scaffold to which chemotactic, circulating proteins and cells (e.g. mesenchymal stem cells, osteoinductive growth factors) can migrate and adhere, and within which progenitor cells can differentiate into functioning osteoblasts (Szpalski and Gunzburg in Orthopedics 25S:601-609, 2002). Indeed, HA may be extemporarily combined either with whole autologous bone marrow or PRP (platelet rich plasma) gel inside surgical theatre in order to favour and accelerate bone regeneration. A case of bifocal ulnar bone defect treated with stoichiometric HA-based bone substitute combined with PRP is reported in here, with a 12-month-radiographic follow-up.

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“…Several studies have been carried out and the results demonstrated that HA can accelerate initial biological response with host tissues at the implanted site in the body and improves the bone-implant adhesion [3], [4]. Evidence of rapid bone formation and subsequently healing around damaged sites in the body were also observed [5], [6].…”

Section: Introductionmentioning

confidence: 90%

Calcination Effects on the Sinterability of Hydroxyapatite Bioceramics

et al. 2011

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Abstract-The sinterability of calcined synthesized HA (700ºC to 1000ºC) was investigated over the temperature range of 1050ºC to 1350ºC in terms of phase stability, bulk density, Young's modulus and Vickers hardness. Calcination has resulted in higher crystallinity of the starting synthesized HA powder. Decomposition of HA phase to form secondary phases was not observed in the present work for the calcined powders. The results also indicated that calcination of the HA powder prior to sintering has negligible effect on the sinterability of the HA compacts (up to 900ºC). Further treatment at 1000ºC was found to be detrimental to the properties of sintered HA.

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Bone substitution in revision hip replacement

Cited by 22 publications

References 32 publications

Full-Field Strain Analysis of Bone–Biomaterial Systems Produced by the Implantation of Osteoregenerative Biomaterials in an Ovine Model

Full-Field Strain Analysis of Bone–Biomaterial Systems Produced by the Implantation of Osteoregenerative Biomaterials in an Ovine Model

Major bone defect treatment with an osteoconductive bone substitute

Calcination Effects on the Sinterability of Hydroxyapatite Bioceramics

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