Bone-targeting poly(ethylene sodium phosphate)

Iwasaki, Yasuhiko; Yokota, Atsushi; Otaka, Akira; Inoue, Naoyuki; Yamaguchi, Akane; Yoshitomi, Toru; Yoshimoto, Keitaro; Neo, Masashi

doi:10.1039/c7bm00930e

Cited by 26 publications

(30 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The strained, cyclic phospholanes that are required for ROP are rather difficult to synthesize and purify; and the polymerization requires stringently dry conditions . ADMET is an attractive alternative approach.…”

Section: Introductionmentioning

confidence: 99%

“…Ionic phosphodiester‐based materials tend to show excellent cellular compatibility, hemocompatibility and a resistance to adsorption of proteins . Adsorption of proteins can induce an inflammatory foreign‐body response so this adverse response will be much reduced in the case of phosphodiester‐coated surfaces .…”

Section: Introductionmentioning

confidence: 99%

“…[18,38] Ionic phosphodiester-based materials tend to show excellent cellular compatibility, hemocompatibility and a resistance to adsorption of proteins. [9,18,28,34,36,39,40] Adsorption of proteins can induce an inflammatory foreign-body response so this adverse response will be much reduced in the case of phosphodiester-coated surfaces. [37,39,41] Furthermore, ionic phosphodiester hydrogels can be used as stimuli responsive polymers and are promising materials to use in for instance bone therapy due to a high Ca 2+ uptake.…”

Section: Introductionmentioning

confidence: 99%

“…[31][32][33] The strained, cyclic phospholanes that are required for ROP are rather difficult to synthesize and purify; and the polymerization requires stringently dry conditions. [7,9,34] ADMET is an attractive alternative approach. However, the residues of potentially toxic heavy metal catalysts can be a cause for concern.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Phosphodiester Hydrogels for Cell Scaffolding and Drug Release Applications

Dera

Diliën

Billen

et al. 2019

Macromolecular Bioscience

View full text Add to dashboard Cite

Given the major structural role phosphodiesters play in the organism it is surprising they have not been more widely adopted as a building block in sophisticated biomimetic hydrogels and other biomaterials. The potential benefits are substantial: phosphoester‐based materials show excellent compatibility with blood, cells, and a remarkable resistance to protein adsorption that may trigger a foreign‐body response. In this work, a novel class of phosphodiester‐based ionic hydrogels is presented which are crosslinked via a phosphodiester moiety. The material shows good compatibility with blood, supports the growth and proliferation of tissue and presents opportunities for use as a drug release matrix as shown with fluorescent model compounds. The final gel is produced via base‐induced elimination from a phosphotriester precursor, which is made by the free‐radical polymerization of a phosphotriester crosslinker. This crosslinker is easily synthesized via multigram one‐pot procedures out of common laboratory chemicals. Via the addition of various comonomers the properties of the final gel may be tuned leading to a wide range of novel applications for this exciting class of materials.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Phosphodiester Hydrogels for Cell Scaffolding and Drug Release Applications

Dera

Diliën

Billen

et al. 2019

Macromolecular Bioscience

View full text Add to dashboard Cite

show abstract

“…Phosphodiester‐based materials possess a number of additional properties that make them valuable for tissue engineers and researchers in the (bio)medical sciences 6. The biomimetic nature of phosphodiesters tends to enhance hemocompatibility and cellular compatibility as well as resisting the adsorption of proteins 6–13. As protein adsorption is the first method by which the organism identifies objects for expulsion by foreign body response, limiting the adsorption of these proteins is desirable 2,11,14,15.…”

Section: Introductionmentioning

confidence: 99%

An Efficient Thermal Elimination Pathway toward Phosphodiester Hydrogels via a Precursor Approach

Dera

Diliën

Adriaensens

et al. 2020

Macro Chemistry & Physics

View full text Add to dashboard Cite

Phosphodiester hydrogels offer a wide range of fascinating properties. Not only do they exhibit excellent hemocompatibility and cellular compatibility, they also show a remarkable resistance to protein adsorption, thereby limiting the foreign body response. In this work, phosphodiester‐crosslinked hydrogels are produced by a simple free‐radical polymerization of a phosphotriester crosslinker. In a second step, this material is transformed to the phosphodiester, by heating it up to 60 °C in phosphate‐buffered saline. Compared to earlier methods, there is no need for acids, bases, or oxidizing agents to achieve this final conversion to the phosphodiester. This method thus reduces the risk to damage or degrade any sensitive biomolecules that might be of interest to tissue engineers, such as various growth factors or other proteins. The phosphotriester crosslinker is readily synthesized out of common laboratory chemicals in multigram quantities with good yield and easy workup and purification.

show abstract

Bone‐targeting phospholipid polymers to solubilize the lipophilic anticancer drug

Otaka

Yamaguchi

Saisho

et al. 2020

J Biomedical Materials Res

View full text Add to dashboard Cite

Current chemotherapy methods have limited effectiveness in eliminating bone metastasis, which leads to a poor prognosis associated with severe bone disorders. To provide regional chemotherapy for this metastatic tumor, a bone‐targeting drug carrier was produced by introducing the osteotropic bisphosphonate alendronate (ALN) units into an amphiphilic phospholipid polymer, poly(2‐methacryloyloxyethyl phosphorylcholine‐co‐n‐butyl methacrylate). The polymer can form nanoparticles with a diameter of less than 30 nm; ALN units were exposed to the outer layer of the particle. A simple mixing procedure was used to encapsulate a hydrophobic anticancer drug, known as docetaxel (DTX), in the polymer nanoparticle, providing a uniform solution of a polymer–DTX complex in the aqueous phase. The complex showed anticancer activities against several breast cancer cell lines, and the complex formation did not hamper the pharmacological effect of DTX. The fluorescence observations evaluated by an in vivo imaging system and fluorescence microscopy showed that the addition of ALN to the polymer–DTX complex enhanced bone accumulation. Bone‐targeting phospholipid polymers are potential solubilizing excipients used to formulate DTX and deliver the hydrophobic drug to bone tissues by blood administration.

show abstract

Bone-targeting poly(ethylene sodium phosphate)

Cited by 26 publications

References 55 publications

Phosphodiester Hydrogels for Cell Scaffolding and Drug Release Applications

Phosphodiester Hydrogels for Cell Scaffolding and Drug Release Applications

An Efficient Thermal Elimination Pathway toward Phosphodiester Hydrogels via a Precursor Approach

Bone‐targeting phospholipid polymers to solubilize the lipophilic anticancer drug

Contact Info

Product

Resources

About