Bone tissue compositional differences in women with and without osteoporotic fracture

McCreadie, Barbara R.; Morris, Michael D.; Chen, Tso ching; Rao, D. Sudhaker; Finney, William F.; Widjaja, Effendi; Goldstein, Steven A.

doi:10.1016/j.bone.2006.06.008

Cited by 234 publications

(224 citation statements)

References 52 publications

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“…This suggests greater carbonate content in the fracture material in comparison to the non-fracture material and/ or less phosphate. A higher carbonate to phosphate ratio in the fracture material is consistent with previous studies [18,28,34]. This increase is consistent with the data reported here, where a~11% increase in the carbonate to phosphate ratio was observed for the fracture material.…”

Section: Ftirsupporting

confidence: 93%

“…No other differences were observed for either cortical or trabecular bone. In contrast, McCreadie et al reported an increase in the carbonate to phosphate ratio between specimens collected from women with and without osteoporotic fractures [28].…”

Section: Introductionmentioning

confidence: 91%

“…the hydroxyapatite mineral) characterised by X-ray diffraction (XRD) [17,24,25] and the organic component (i.e. collagen) as characterised by Raman spectroscopy [28,29] or Fourier transform infra-red spectroscopy (FTIR) [26, 30 -33]. Perhaps of most relevance are those reports detailing differences between osteoporotic and 'normal' tissues, although inconsistencies are frequent.…”

Section: Introductionmentioning

confidence: 99%

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Towards new material biomarkers for fracture risk

Greenwood

Clement

Dicken

et al. 2016

Bone

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Osteoporosis is a prevalent bone condition, characterised by low bone mass and increased fracture risk. Currently, the gold standard for identifying osteoporosis and increased fracture risk is through quantification of bone mineral density (BMD) using dual energy X-ray absorption (DEXA). However, the risk of osteoporotic fracture is determined collectively by bone mass, architecture and physicochemistry of the mineral composite building blocks. Thus DEXA scans alone inevitably fail to fully discriminate individuals who will suffer a fragility fracture. This study examines trabecular bone at both ultrastructure and microarchitectural levels to provide a detailed material view of bone, and therefore provides a more comprehensive explanation of osteoporotic fracture risk. Physicochemical characterisation obtained through X-ray diffraction and infrared analysis indicated significant differences in apatite crystal chemistry and nanostructure between fracture and non-fracture groups.Further, this study, through considering the potential correlations between the chemical biomarkers and microarchitectural properties of trabecular bone, has investigated the relationship between bone mechanical properties (e.g. fragility) and physicochemical material features.

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Section: Ftirsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

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Towards new material biomarkers for fracture risk

Greenwood

Clement

Dicken

et al. 2016

Bone

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“…Other studies indicate that the relative composition of mineral and collagen matrix is altered during aging, in favor for more mineral (Boskey and Mendelsohn, 2005;McCreadie et al, 2006). The collagen matrix is most likely affected during aging (Bailey and Knott, 1999;Viguet-Carrin et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Long-term voluntary exercise of male mice induces more beneficial effects on cancellous and cortical bone than on the collagenous matrix

Isaksson

Tolvanen

Finnilä

et al. 2009

Experimental Gerontology

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. ACCEPTED MANUSCRIPT ABSTRACT:The effects of lifelong physical exercise on the composition, structure and mechanical properties of bone are not well understood. Earlier, we found that voluntary physical exercise improved various properties of bone in maturing male mice up to 6 months of age. In the present study, we extended the previous study to 18 months. Half of the mice (total N=144) had access to running wheels while half were kept sedentary. The collagen network was assessed biochemically and by tensile testing of decalcified bone. The mineralized femur was analyzed with pQCT and 3-point-bending of the diaphysis and neck-strength-test. The proximal tibia was analyzed with microCT. The bone collagen revealed inferior tensional properties with aging and the mineralized femur demonstrated decreased stiffness with age. In the running mice, tensile properties and the BMD were reduced at 18 months of age compared to the sedentary mice. In contrast, the stiffness of both the diaphysis and femoral neck was higher, and trabecular architecture and structure were improved in the running mice. In summary, the results suggest that lifelong exercise training of male mice results in more beneficial effects on intact mineralized bone in both the diaphysis and epiphysis than on bone collagenous matrix.

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“…Fuchs et al [19] used FTIR to examine the time course of the mineralization of Haversian systems. Raman spectroscopy does not require the tissue to be dried and therefore has the potential, not yet fully realized, for in vivo examination [29]. NMR spectroscopy measures the amount of water in different compartments in the bone, bound and mobile particularly.…”

Section: New Methods For Characterizing Bonementioning

confidence: 99%