Bone tissue response to plasma-nitrided titanium implant surfaces

Abstract

A current goal of dental implant research is the development of titanium (Ti) surfaces to improve osseointegration. Plasma nitriding treatments generate surfaces that favor osteoblast differentiation, a key event to the process of osteogenesis. Based on this, it is possible to hypothesize that plasma-nitrided Ti implants may positively impact osseointegration. Objective The aim of this study was to evaluate the in vivo bone response to Ti surfaces modified by plasma-nitriding treatments.Material and Methods Surface treatments consisted of 20% N2 and 80% H2, 450°C and 1.5 mbar during 1 h for planar and 3 h for hollow cathode. Untreated surface was used as control. Ten implants of each surface were placed into rabbit tibiae and 6 weeks post-implantation they were harvested for histological and histomorphometric analyses.Results Bone formation was observed in contact with all implants without statistically significant differences among the evaluated surfaces in terms of bone-to-implant contact, bone area between threads, and bone area within the mirror area.Conclusion Our results indicate that plasma nitriding treatments generate Ti implants that induce similar bone response to the untreated ones. Thus, as these treatments improve the physico-chemical properties of Ti without affecting its biocompatibility, they could be combined with modifications that favor bone formation in order to develop new implant surfaces.

Effect of the Acid-Etching on Grit-Blasted Dental Implants to Improve Osseointegration: Histomorphometric Analysis of the Bone-Implant Contact in the Rabbit Tibia Model

“…A quantitative method is required for the measurement of implant stability and osseointegration [14]. Resonance frequency analysis (RFA), which was introduced by Meredith, has been proposed as a non-invasive and non-destructive means to measure implant integration and detect stability changes over time [15,16] and assist in preventing osseointegration failures that show reduced stability over time [17]. The increase/decrease at the implant-to-bone interface in healing variations can be measured and registered by resonance frequency analysis (RFA) [17,18].…”

Morphological Evaluation of Tissue Reaction Response to the Titanium Implants for Cranioplasty. Experimental Study

“…Несмотря на значительное количество работ [27][28][29], в основном в области стоматологии, травматологии и ортопедии, по изучению реакции тканей человека и животных [30], а также остеоинтеграции титановых имплантатов [31][32][33], проведение эксперимента было продиктовано необходимостью исследования реакций мягких тканей организма на новые типы изделий, получаемых методом трехмерной печати. В области нейрохирургии изучение морфологических изменений в окружающих имплантат мягких тканях имеет больший приоритет, чем при интеграции имплантата в плоские кости черепа.…”

The effect of collagen coating on titanium with nanotopography on in vitro osteogenesis

“…To elicit proper osseointegration, titanium (Ti) is the biomaterial of choice, thanks to its mechanical properties and high biocompatibility. However, some challenging clinical cases have driven research to the development of Ti surface modifications to improve cell differentiation and ultimately increase bone formation directly in contact with Ti implants . The different treatments of Ti surfaces have been categorized as morphological, physicochemical, biochemical, and their combinations …”

“…However, some challenging clinical cases have driven research to the development of Ti surface modifications to improve cell differentiation and ultimately increase bone formation directly in contact with Ti implants. [1][2][3][4][5][6] The different treatments of Ti surfaces have been categorized as morphological, physicochemical, biochemical, and their combinations. 7 Surface modifications that result in nanostructured patterns may modulate osteoblast responses from early to late stages of differentiation.…”