The author in this study presents the new term called “Quadruple Change” as a framework for delivering high-value digital transformation in organizations. The quadruple change consists of technical, organizational, social, and global change during digital transformation. The author conducted a qualitative exploratory study to explore strategies that leaders need to adopt to cultivate transformation agents during digital transformation toward establishing sustainability. The study revealed that for successful digital transformation, organizations need to empower employees, engage them in the process of change, and develop the culture of transformation in the dynamic environment. Toward this achievement, cultivating transformation agents based on quadruple change is one of the significant steps. The study findings identified seven factors contributing to cultivating transformation agents in organizations, including vision creation, mindset change, knowledge improvement, innovation development, motivation increment, leadership support, and collaboration.