Book Review: Gibaldi's Drug Delivery Systems in Pharmaceutical Care

Abstract

complicationssuch as renal bone disease encouragesthe reader to fully explore the nuances of these conditions and their drug therapy. Hemodialysis and peritoneal dialysisare nicelypresented for individuals unfamiliar with the actual mechanicsof these procedures.The chapters on dietarymanagement, palliative care, and traveling for the renalpatient help enlighten the pharmacy practitioner in areas not usuallycovered in generaltherapeutic texts. Limitations: The book utilizes SI units. It does not give the conventional units. As such, serum creatinineis reportedthroughoutthe text in micromoles per liter rather than in milligrams per deciliter. Important equations in the evaluation of renal patients, such as the Cockcroft-Gault,are likewiseformulated in micromoles per liter.This may be confusing to the very audiencefor which the book is intended-individuals not well versed in the field.Includingconventional as well as SI units in forthcoming editionswouldbe of benefit. Some drug therapies or formulations discussedare not available in the US. Guidelinesfor managementof the variousrenal complications such as renal anemiaare based on the Europeanguidelines. These differences may confusea new clinicianor student. The chapter on hypertension is a general discussion not targeted specifically to the renal patient.The chapterentitled"Drug-Induced Kidney Disease" is only 6 pages long and contains only 4 references; this is terse coverage in a text aimed at pharmacy practitioners. A couple of other chapters are also weakly referenced. A chapter dedicated to the psychological issues and their management in renal patients would be usefulfor futureeditions. Reviewer's Summary: This book will be of valueto anyoneinterested in expandinghis or her knowledgeabout drug therapyfor the renally impaired patient. Individualsroutinely using conventionalunits should be prepared to convert various laboratory test results from the SI units. Europeanor United Kingdom guidelinesfor managementof renallyrelated problemsare used and may differfrom those used in the US.

Drug Transporters

“…In general, lipophilic drugs are better absorbed than hydrophilic drugs, the latter usually presenting slow absorption kinetics and incomplete absorption. As mentioned in the previous sections, ionizable molecules reach their maximum absorption rate at pH values that minimize their ionization (Desai 2007).…”

Stabilisasi Liposom dalam Sistem Penghantaran Obat

“…Salah satu metode stabilsasi liposom yang telah diselidiki yaitu liofilisasi atau metode pengeringan beku. 27,28 Pengeringan beku merupakan metode yang dapat digunakan untuk menstabilkan sistem koloid. Namun, kebocoran obat yang terperangkap dapat terjadi selama proses pengeringan beku.…”

Appropriate use of transdermal drug delivery systems

“…If possible, the backing film should be constructed in such a way that is it clearly visible to others. Common components of backing films include clear or colored aluminum films, polyethylenes, polyurethanes, or polyesters [13] . Second, both patch types contain an adhesive layer.…”