Boosting Photothermal Theranostics via TICT and Molecular Motions for Photohyperthermia Therapy of Muscle‐Invasive Bladder Cancer (Adv. Healthcare Mater. 24/2021)

Zhang, Sheng; Hong, Gao; Li, Chuang; Xing, Shaoqiang; Xu, Zhaoliang; Liu, Qian; Feng, Guangxue

doi:10.1002/adhm.202170118

Cited by 4 publications

(3 citation statements)

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“…However, in comparison to PFAz‐SQ‐2 ( E g =1.93 eV), PFAz‐SQ‐1 exhibits a lower HOMO–LUMO energy gap ( E g =1.72 eV). The reduced energy gap of PFAz‐SQ‐1 suggests the potential for a greater redshift in the absorption band within the NIR region [9d] . Further, we performed vertical excitation calculations based on the optimized structures of the two molecules shown in Figure 1 to obtain simulated absorption spectra.…”

Section: Resultsmentioning

confidence: 99%

Fused Azulenyl Squaraine Derivatives Improve Phototheranostics in the Second Near‐Infrared Window by Concentrating Excited State Energy on Non‐Radiative Decay Pathways

Gao,

Yao,

et al. 2024

Angew Chem Int Ed

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The second near‐infrared (NIR‐II) theranostics offer new opportunities for precise disease phototheranostic due to the enhanced tissue penetration and higher maximum permissible exposure of NIR‐II light. However, traditional regimens lacking effective NIR‐II absorption and uncontrollable excited‐state energy decay pathways often result in insufficient theranostic outcomes. Herein a phototheranostic nano‐agent (PS‐1 NPs) based on azulenyl squaraine derivatives with a strong NIR‐II absorption band centered at 1092 nm is reported, allowing almost all absorbed excitation energy to dissipate through non‐radiative decay pathways, leading to high photothermal conversion efficiency (90.98%) and strong photoacoustic response. Both in vitro and in vivo photoacoustic/photothermal therapy results demonstrate enhanced deep tissue cancer theranostic performance of PS‐1 NPs. Even in the 5 mm deep‐seated tissue tumor model, PS‐1 NPs demonstrated a satisfactory anti‐tumor effect in photoacoustic imaging‐guided photothermal therapy. Moreover, for the human extracted tooth root canal infection model, the synergistic outcomes of the photothermal effect of PS‐1 NPs and 0.5% NaClO solution resulted in therapeutic efficacy comparable to the clinical gold standard irrigation agent 5.25% NaClO, opening up possibilities for the expansion of NIR‐II theranostic agents in oral medicine.

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Section: Resultsmentioning

confidence: 99%

Fused Azulenyl Squaraine Derivatives Improve Phototheranostics in the Second Near‐Infrared Window by Concentrating Excited State Energy on Non‐Radiative Decay Pathways

Gao,

Yao,

et al. 2024

Angew Chem Int Ed

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“…designed a photothermal agent BBTD+GA/PEG‐RGD with high PCE values by promoting nonradiative heat generation processes through the cooperation of twisted intramolecular charge transfer (TICT) and molecular motions, which facilitate the effective low‐temperature hyperthermia therapy of muscle‐invasive BC. [ 113 ] However, tumor hypoxia makes the great application prospect of PDT unfulfilled. Lin et al.…”

Section: Therapy For Bcmentioning

confidence: 99%

Designing Intelligent Nanomaterials to Achieve Highly Sensitive Diagnoses and Multimodality Therapy of Bladder Cancer

Chen

et al. 2023

Small Methods

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Bladder cancer (BC) is among the most common malignant tumors of the genitourinary system worldwide. In recent years, the rate of BC incidence has increased, and the recurrence rate is high, resulting in poor quality of life for patients. Therefore, how to develop an effective method to achieve synchronous precise diagnoses and BC therapies is a difficult problem to solve clinically. Previous reports usually focus on the role of nanomaterials as drug delivery carriers, while a summary of the functional design and application of nanomaterials is lacking. Summarizing the application of functional nanomaterials in high‐sensitivity diagnosis and multimodality therapy of BC is urgently needed. This review summarizes the application of nanotechnology in BC diagnosis, including the application of nanotechnology in the sensoring of BC biomarkers and their role in monitoring BC. In addition, conventional and combination therapies strategy in potential BC therapy are analyzed. Moreover, different kinds of nanomaterials in BC multimodal therapy according to pathological features of BC are also outlined. The goal of this review is to present an overview of the application of nanomaterials in the theranostics of BC to provide guidance for the application of functional nanomaterials to precisely diagnose and treat BC.

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“…A PA signal at the tumor site was detected after 6 h, validating the successful conversion of TBTO into TBT under hypoxia (Figure 10d). As a strong donor, the dimethylamine group can easily undergo excited‐state rotation to cause a dark state to promote the light‐to‐heat conversion, and thus represents an excellent building block to engineer efficient photothermal and photoacoustic systems [43] …”

Section: Photoacoustic Systemsmentioning

confidence: 99%

Molecular Motion and Nonradiative Decay: Towards Efficient Photothermal and Photoacoustic Systems

Shen

et al. 2022

Angewandte Chemie

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Nonradiative decay invariably competes with radiative decay during the deexcitation process of matter. In the community of luminescence research, nonradiative decay has been deemed less attractive than radiative decay. However, all things in their being are good for something and so is nonradiative decay. As the molecular motion‐facilitated nonradiative decay (MMFND) effect is inevitable in photophysical processes, it provides a new avenue to convert the harvested light energy into exploitable forms by harnessing molecular motion. In many cases, active molecular motion enables thermal deactivation from excited states. In this Minireview, recent advances in photothermal and photoacoustic systems with MMFND character are summarized. We believe that this presentation of the rational engineering of molecular motion for efficient photothermal generation will deepen the understanding of the relationship between molecular motion and nonradiative decay and navigate people to rethink the positive aspects of nonradiative decay for the establishment of new light‐controllable techniques.

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Boosting Photothermal Theranostics via TICT and Molecular Motions for Photohyperthermia Therapy of Muscle‐Invasive Bladder Cancer (Adv. Healthcare Mater. 24/2021)

Cited by 4 publications

References 0 publications

Fused Azulenyl Squaraine Derivatives Improve Phototheranostics in the Second Near‐Infrared Window by Concentrating Excited State Energy on Non‐Radiative Decay Pathways

Fused Azulenyl Squaraine Derivatives Improve Phototheranostics in the Second Near‐Infrared Window by Concentrating Excited State Energy on Non‐Radiative Decay Pathways

Designing Intelligent Nanomaterials to Achieve Highly Sensitive Diagnoses and Multimodality Therapy of Bladder Cancer

Molecular Motion and Nonradiative Decay: Towards Efficient Photothermal and Photoacoustic Systems

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