This chapter aims to assess how humane orientation as a cultural value and prior experience in social problems (dependent variable) influence social entrepreneurial intention (SEI, independent variable) of students of tourism management. The additional antecedents of SEI, such as empathy, moral obligation, social self-efficacy, and perceived social support, were entered into the research model as mediating variables between independent and dependent variables. The research was conducted on a sample of 70 students enrolled in studies of tourism management in the Republic of Serbia. The results of single mediation regression analysis indicate that empathy and perceived social support are mediators between the dependent and independent variables, while moral obligation and perceived social support are not. Results of the study present implications both for theory and practice in the area of social entrepreneurship of university students.