Boosting the Sensitivity and Selectivity of a Miniature Mass Spectrometer Using a Hybrid Ion Funnel

Zhai, Yanbing; Xu, Qiu; Tang, Yang; Liu, Siyu; Li, Dayu; Xu, Wei

doi:10.1021/acs.analchem.9b01770

Cited by 23 publications

(22 citation statements)

References 55 publications

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“…The sensitivity for l -tryptophan, DMMP, and PC increased by 10.8-, 6.8-, and 6.7-fold, respectively, while for angiotensin II 1+ and 2+, the sensitivity increased by factors of 2.6 and 2.0, respectively, by using ESI-APIF compared to ESI-MS (Table ). By using conventional ESI-MS, the LODs for l -tryptophan and reserpine were 52.6 ± 4.1 and 1.47 ± 0.04 nM, respectively, which are comparable to the values reported in the literature by other groups using ESI-based MS methods with linear and 3D quadrupole ion traps (12.2–245 and 1.6–8.2 nM, respectively). − By using ESI-APIF-MS, the LODs for DMMP, l -tryptophan, PFOA, reserpine, PC, and angiotensin II (1+ and 2+) were lowered by up to 2.9× to values of 0.143, 20.1, 0.106, 0.691, 48.43, 328.6, and 138.1 nM, respectively, compared to those obtained using conventional ESI-MS (Table ).…”

Section: Resultssupporting

confidence: 76%

Ambient Pressure Ion Funnel: Concepts, Simulations, and Analytical Performance

et al. 2020

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In mass spectrometry (MS), a major loss of ions can readily occur during their transfer from atmospheric pressure to a lower pressure, which limits performance. Here, we report an ion funnel that can be used to effectively focus ions at ambient pressure (∼777 Torr) to significantly enhance performance in electrospray ionization (ESI) MS. For seven singly charged test ions (m/z 124− 1131), the ambient pressure ion funnel (APIF) is demonstrated to improve ion abundances, sensitivity, and detection limits by up to factors of ∼17, ∼16, and ∼3, respectively, compared to the operation of conventional ESI-MS. Simulated ion trajectories were used to rationalize the enhanced performance of the APIF, which is attributed primarily to using a relatively high RF field amplitude to radially confine ions, a high DC field, and a wide exit ring electrode. The effective focusing of ions at ambient pressures should be beneficial in the future for improving the performance of (i) additional methods that ionize molecules at atmospheric pressure, (ii) ambient pressure ion mobility-based instruments, and (iii) high flow rate liquid chromatography mass spectrometry platforms.

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Section: Resultssupporting

confidence: 76%

Ambient Pressure Ion Funnel: Concepts, Simulations, and Analytical Performance

et al. 2020

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“…An ion funnel can improve ion transmission efficiency, focusing the moving ions radially 21 and reducing ion loss. [22][23][24] Besides, ion transmission efficiency can be improved by using a supplemental electron source inside the skimmer. 25 There are ion losses at each ion gate when the ions move from the ionization source to the mass analyzer.…”

Section: Introductionmentioning

confidence: 99%

Quantification and evaluation of ion transmission efficiency in two‐stage vacuum chamber miniature mass spectrometer

Guo

Diao²,

Liu

et al. 2022

J Mass Spectrom

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Miniature mass spectrometer is more compact and portable than traditional commercial mass spectrometry, with more potential for application outside the laboratory.However, a miniature mass spectrometer is less sensitive than a commercial instrument, limiting its application scenarios. The ion transmission efficiency of the instrument is an essential factor affecting the sensitivity. Still, there are few works of

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“…Developments in the ion transmission systems improve the transmission efficiency of ions from the ambient atmosphere to the mass analyzers. Novel ion funnel and ion lens were developed to focus and transfer ions more efficiently (Zhai et al, 2019;Snyder et al, 2020). The transmission efficiency of ions can be improved with these techniques.…”

Section: Introductionmentioning

confidence: 99%

Towards Higher Sensitivity of Mass Spectrometry: A Perspective From the Mass Analyzers

Li¹,

Chu²,

Tan³

et al. 2021

Front. Chem.

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Mass spectrometry (MS) is one of the most widely used analytical techniques in many fields. Recent developments in chemical and biological researches have drawn much attention to the measurement of substances with low abundances in samples. Continuous efforts have been made consequently to further improve the sensitivity of MS. Modifications on the mass analyzers of mass spectrometers offer a direct, universal and practical way to obtain higher sensitivity. This review provides a comprehensive overview of the latest developments in mass analyzers for the improvement of mass spectrometers’ sensitivity, including quadrupole, ion trap, time-of-flight (TOF) and Fourier transform ion cyclotron (FT-ICR), as well as different combinations of these mass analyzers. The advantages and limitations of different mass analyzers and their combinations are compared and discussed. This review provides guidance to the selection of suitable mass spectrometers in chemical and biological analytical applications. It is also beneficial to the development of novel mass spectrometers.

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Boosting the Sensitivity and Selectivity of a Miniature Mass Spectrometer Using a Hybrid Ion Funnel

Cited by 23 publications

References 55 publications

Ambient Pressure Ion Funnel: Concepts, Simulations, and Analytical Performance

Ambient Pressure Ion Funnel: Concepts, Simulations, and Analytical Performance

Quantification and evaluation of ion transmission efficiency in two‐stage vacuum chamber miniature mass spectrometer

Towards Higher Sensitivity of Mass Spectrometry: A Perspective From the Mass Analyzers

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