Borapetoside C from Tinospora crispa improves insulin sensitivity in diabetic mice

Ruan, Chi Tun; Lam, Sio-Hong; Cherng, Tzong; Lee, Shoei‐Sheng; Su, Ming‐Jai

doi:10.1016/j.phymed.2012.03.009

Cited by 52 publications

(40 citation statements)

References 33 publications

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“…In this line, natural substances such as the terpenoid borapetoside C and food flavoring preservative agents increase the expression of hepatic GLUT-2 in diabetic mice, which has been related to the hypoglycemic effect [41,44]. Similarly, the anti-diabetic drugs telmisartan, sitagliptin and metformin increase the levels of hepatic GLUT-2 on insulin-resistant mice, pointing to the normalization of post-receptor insulin signaling and the restoration of the hepatic insulin sensitivity [45].…”

Section: Discussionmentioning

confidence: 99%

Cocoa-rich diet ameliorates hepatic insulin resistance by modulating insulin signaling and glucose homeostasis in Zucker diabetic fatty rats

Cordero-Herrera

Martín

Escrivá

et al. 2015

The Journal of Nutritional Biochemistry

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Section: Discussionmentioning

confidence: 99%

Cocoa-rich diet ameliorates hepatic insulin resistance by modulating insulin signaling and glucose homeostasis in Zucker diabetic fatty rats

Cordero-Herrera

Martín

Escrivá

et al. 2015

The Journal of Nutritional Biochemistry

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“…An alkaloid isolated from T. crispa has cytotoxic activity against Toxoplasma gondii [50]. Borapetoside C, isolated from T. crispa , improved insulin sensitivity in diabetic mice [51]. Praman et al isolated five compounds (uridine, adenosine, higenamine, salsolinol, and tyramine) from T. crispa and proved the effects of these compounds on the cardiovascular system, particularly on the reduction of blood pressure [52].…”

Section: Discussionmentioning

confidence: 99%

Immunomodulatory effect of an isolated fraction from Tinospora crispa on intracellular expression of INF-γ, IL-6 and IL-8

Abood

Fahmi

Abdulla

et al. 2014

BMC Complement Altern Med

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BackgroundImmunomodulators are substances that modify immune system response to a threat. Immunomodulators modulate and potentiate the immune system, keeping it highly prepared for any threat. The immunomodulatory effect of the traditional medicine Tinospora crispa is investigated in this work.MethodsT. crispa ethanol extract was fractionated by using different solvents. The ethanol extract and effective isolated fraction were used to investigate the potential immunomodulatory effect of different T. crispa doses ranging from 25 μg/mL to 1000 μg/mL on RAW 246.7 cells by detecting intracellular INF-γ, IL-6, and IL-8 expressions. The antioxidant activity of T. crispa was evaluated through FRAP and DPPH. The total phenolic and total flavonoid contents were also quantified.ResultsResults show that T. crispa extract has higher antioxidant potential than ascorbic acid. The FRAP value of T. crispa extract is 11011.11 ± 1145.42 μmol Fe+2/g, and its DPPH inhibition percentage is 55.79 ± 7.9, with 22 μg/mL IC50. The results also reveal that the total phenolic content of T. crispa extract is 213.16- ± 1.31 mg GAE/g dry stem weight, and the total flavonoid content is 62.07- ± 39.76 mg QE/g dry stem weight. T. crispa crude extract and its isolated fraction significantly stimulate RAW264.7 cell viability (P ≤ 0.05) and intracellular INF-γ, IL-6, and IL-8 expressions. The results of LC-MS show that four of the active compounds detected in the T. crispa isolated fraction are cordioside, quercetin, eicosenoic acid (paullinic acid), and boldine.ConclusionsThe results of this study obviously indicate that T. crispa has immunomodulatory effects through the stimulation of INF-γ, IL-6, and IL-8 expressions. LC-MS phytochemical analysis showed that the T. crispa fraction has cordioside, quercetin, eicosenoic acid (paullinic acid), and boldine, which may be responsible for the immunostimulator effect of T. crispa.

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“…Teucrium polium Lamiaceae Sucrose-induced insulin resistance in rat Improves the liver function [138] 100 Tinospora cordifolia Menispermaceae High-fructose diet rats Activates the following enzymes: hexokinase, phosphofructokinase, pyruvate kinase, glucose-6-phosphatase, fructose-1,6-bisphosphatase, and glucose-6-phosphate dehydrogenase [139,140] 101 Tinospora crispa Menispermaceae Diabetic mice Increases phosphorylation of IR and protein kinase B (Akt) as well as the expression of GLUT2 [141] 102…”

Section: Stevia Rebaudianamentioning

confidence: 99%

“…Methylswertianin and bellidifolin [133] 29 Tetrastigma obtectum Flavonoids [137] 30 Tinospora crispa Borapetoside C [141] 31…”

Section: Swertia Puniceamentioning

confidence: 99%

“…The activation of insulin receptor and PKB as well as the expression of glucose transporter-2 and the enhancement of insulin sensitivity may contribute to the hypoglycaemic action of borapetoside C in diabetic mice. [141] Finally, quercetin and quercetin 3-O-glycosides isolated from Eeyou Istchee were found to have potential applications for the prevention and treatment of insulin resistance in C2C12 muscle cells by stimulating glucose uptake and the AMPK pathway. [147] In this review the in-vivo studies evaluating the whole body insulin sensitivity have used mainly the homeostasis model of insulin sensitivity index, while a few investigations have used the euglycemic hyperinsulinemic clamp, which remains the principle technique available for the precise assessment of insulin sensitivity in vivo.…”

Section: Vaccinium Vitis-idaeamentioning

confidence: 99%

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Antidiabetic plants improving insulin sensitivity

Eddouks¹,

Bidi²,

Bouhali³

et al. 2014

Journal of Pharmacy and Pharmacology

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Background Globally, the prevalence of diabetes mellitus is increasing at an alarming rate. This chronic pathology gravely troubled the human health and quality of life. Both insulin deficiency and insulin resistance are involved in the pathophysiology of diabetes mellitus. Moreover, insulin resistance is being diagnosed nowadays in a growing population of diabetic and obese patients, especially in industrialized societies. There are lots of conventional agents available to control and to treat diabetes, but total recovery from this disorder has not been reported up to this date. Plants provided a potential source of hypoglycemic drugs and are widely used in several traditional systems of medicine to prevent diabetes. A few reviews with less attention paid to mechanisms of action have been published on antidiabetic plants. Objectives The present review focuses on the various plants that have been reported to be effective in improving insulin sensitivity associated with diabetes. Key findings In this work, an updated systematic review of the published literature has been conducted to review the antidiabetic plants improving insulin sensitivity and 111 medicinal plants have been reported to have a beneficial effect on insulin sensitivity using several in-vitro and in-vivo animal models of diabetes. Conclusion The different metabolic and cellular effects of the antidiabetic plants improving insulin sensitivity are reported indicating the important role of medicinal plants as potential alternative or complementary use in controlling insulin resistance associated with diabetes mellitus.

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Borapetoside C from Tinospora crispa improves insulin sensitivity in diabetic mice

Cited by 52 publications

References 33 publications

Cocoa-rich diet ameliorates hepatic insulin resistance by modulating insulin signaling and glucose homeostasis in Zucker diabetic fatty rats

Cocoa-rich diet ameliorates hepatic insulin resistance by modulating insulin signaling and glucose homeostasis in Zucker diabetic fatty rats

Immunomodulatory effect of an isolated fraction from Tinospora crispa on intracellular expression of INF-γ, IL-6 and IL-8

Antidiabetic plants improving insulin sensitivity

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