Border disease in cattle

Braun, Ueli; Hilbe, Monika; Peterhans, Ernst; Schweizer, Matthias

doi:10.1016/j.tvjl.2019.01.006

Cited by 32 publications

(34 citation statements)

References 101 publications

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“…Even though prevalence studies of ruminant pestiviruses in swine are relatively rare, several reports have supported the adaptive plasticity of BDV to cross the species barrier and infect swine (Kawanishi et al, ; Nagai et al, ; Rosell et al, ; Vilček & Belák, ) and cattle (Braun, Hilbe, Peterhans, & Schweizer, ). Experimental in vivo studies in sheep and pigs will better ascertain if the novel ovine pestivirus is able to reproduce the disease and cross the species barrier.…”

Section: Resultsmentioning

confidence: 99%

Serological relationship between a novel ovine pestivirus and classical swine fever virus

Casciari

Sozzi

Bazzucchi

et al. 2020

Transbound Emerg Dis

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The genus Pestivirus comprises globally distributed members of the family Flaviviridae, which cause severe losses in livestock. The most common species of the genus are bovine viral diarrhoea virus type 1 (BVDV‐1) and type 2 (BVDV‐2), classical swine fever virus (CSFV) and border disease virus (BDV). Recently, a novel ovine pestivirus was repeatedly detected in aborted lamb foetuses on a farm located in the Brescia Province (Italy). Complete genome characterization of this isolate showed that it was highly divergent from known pestivirus species and that it was genetically closely related to CSFV. The aim of this study was to determine the serological relatedness between the identified novel pestivirus and BVDV, BDV and CSFV selected strains for which homologous serum was available, by antigenic characterization performed using cross‐neutralization assays. The serological relatedness was expressed as the coefficient of antigenic similarity (R). Both field and specific antisera raised against the ovine pestivirus neutralized the CSFV reference strain Diepholz with titres significantly higher than those specific for the BDV and BVDV strains. Furthermore, the calculated R values clearly indicated that the novel ovine pestivirus is antigenically more related to CSFV than to ruminant pestiviruses, in agreement with the results of the genomic analysis. This would have severe consequences on CSFV serology in the event of a switch to porcine hosts with implications for CSFV surveillance and porcine health management.

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Section: Resultsmentioning

confidence: 99%

Serological relationship between a novel ovine pestivirus and classical swine fever virus

Casciari

Sozzi

Bazzucchi

et al. 2020

Transbound Emerg Dis

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“…Animals with persistent infection play an important role in the epidemiology of pestiviruses in swine and ruminants. The host range is variable depending on the Pestivirus species; some pestiviruses such as BVD-1, BVD-2, and BDV, with ruminants as main hosts, are able to cross species barriers and infect a wide range of hosts [9,10]. By contrast, others like CSFV have a restricted natural host range and infect only swine including wild and domestic pigs.…”

Section: Introductionmentioning

confidence: 99%

Decrypting the Origin and Pathogenesis in Pregnant Ewes of a New Ovine Pestivirus Closely Related to Classical Swine Fever Virus

Wang¹,

Sozzi

Bohórquez³

et al. 2020

Viruses

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This study shows the origin and the pathogenic role of a novel ovine pestivirus (OVPV) isolated in 2017 in Italy, as a pathogenic agent causing severe abortions after infection in pregnant ewes and high capacity for virus trans-placental transmission as well as the birth of lambs suffering OVPV-persistent infection. The OVPV infection induced early antibody response detected by the specific ELISA against classical swine fever virus (CSFV), another important virus affecting swine. The neutralizing antibody response were similar against CSFV strains from genotype 2 and the OVPV. These viruses showed high identity in the B/C domain of the E2-glycoprotein. Close molecular diagnostics cross-reactivity between CSFV and OVPV was found and a new OVPV molecular assay was developed. The phylodynamic analysis showed that CSFV seems to have emerged as the result of an inter-species jump of Tunisian sheep virus (TSV) from sheep to pigs. The OVPV and the CSFV share the TSV as a common ancestor, emerging around 300 years ago. This suggests that the differentiation of TSV into two dangerous new viruses for animal health (CSFV and OVPV) was likely favored by human intervention for the close housing of multiple species for intensive livestock production.

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“…The genus Pestivirus belongs to the family Flaviviridae and contains several veterinary-relevant virus species with major animal welfare and economic importance like pestivirus A and B (bovine viral diarrhea virus types 1 and 2, BVDV-1 and -2), pestivirus D (border disease virus, BDV) and pestivirus C (classical swine fever virus, CSFV) [1][2][3][4]. The host range of the classical pestivirus species includes cloven-hoofed animals.…”

Section: Introductionmentioning

confidence: 99%

A CRISPR/Cas9 Generated Bovine CD46-knockout Cell Line—A Tool to Elucidate the Adaptability of Bovine Viral Diarrhea Viruses (BVDV)

Szillat

Koethe

Wernike

et al. 2020

Viruses

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Bovine viral diarrhea virus (BVDV) entry into a host cell is mediated by the interaction of the viral glycoprotein E2 with the cellular transmembrane CD46 receptor. In this study, we generated a stable Madin–Darby Bovine Kidney (MDBK) CD46-knockout cell line to study the ability of different pestivirus A and B species (BVDV-1 and -2) to escape CD46-dependent cell entry. Four different BVDV-1/2 isolates showed a clearly reduced infection rate after inoculation of the knockout cells. However, after further passaging starting from the remaining virus foci on the knockout cell line, all tested virus isolates were able to escape CD46-dependency and grew despite the lack of the entry receptor. Whole-genome sequencing of the escape-isolates suggests that the genetic basis for the observed shift in infectivity is an amino acid substitution of an uncharged (glycine/asparagine) for a charged amino acid (arginine/lysine) at position 479 in the ERNS in three of the four isolates tested. In the fourth isolate, the exchange of a cysteine at position 441 in the ERNS resulted in a loss of ERNS dimerization that is likely to influence viral cell-to-cell spread. In general, the CD46-knockout cell line is a useful tool to analyze the role of CD46 for pestivirus replication and the virus–receptor interaction.

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Border disease in cattle

Cited by 32 publications

References 101 publications

Serological relationship between a novel ovine pestivirus and classical swine fever virus

Serological relationship between a novel ovine pestivirus and classical swine fever virus

Decrypting the Origin and Pathogenesis in Pregnant Ewes of a New Ovine Pestivirus Closely Related to Classical Swine Fever Virus

A CRISPR/Cas9 Generated Bovine CD46-knockout Cell Line—A Tool to Elucidate the Adaptability of Bovine Viral Diarrhea Viruses (BVDV)

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