Borderline nuclear change, high‐grade dyskaryosis not excluded: current concepts and impact on clinical practice

Hoo, S. Soo; Patel, Amit; Buist, H.; Galaal, Khadra; Hemming, J.D.; Naik, Raj

doi:10.1111/j.1365-2303.2011.00943.x

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…Because HPV testing has a known (albeit low) false‐negative rate, 23 a negative hrHPV test result in the presence of ASC‐H cytology does not guarantee the absence of high‐grade CIN and such women may require careful follow‐up rather than routine recall. Irrespective of hrHPV status, a second issue relates to the relatively high positive predictive value of ASC‐H for CIN2 or worse lesions, averaging at around 40% 24–26 . Given these data, it may be unwise to disregard ASC‐H cytology in women with negative colposcopic findings, as not all high‐grade lesions are visible at colposcopy 27 .…”

Section: Discussionmentioning

confidence: 99%

Image analysis of hyperchromatic crowded cell groups in SurePath cervical cytology

Evered

Edwards

Powell³

2013

Cytopathology

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The area, shape and colour intensity of HCCGs, either alone or in combination, have little discriminative value. Practitioners and trainers should focus on the well-established features of dyskaryosis, such as chromatin pattern, nuclear membrane irregularities and group architecture. In terms of morphometric analysis, DNA ploidy and chromatin texture analysis may be more fruitful avenues of investigation.

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Section: Discussionmentioning

confidence: 99%

Image analysis of hyperchromatic crowded cell groups in SurePath cervical cytology

Evered

Edwards

Powell³

2013

Cytopathology

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“…The ALTS study demonstrated the value of subcategorizing ASC‐US and ASC‐H with 41% of ASC‐H cases having underlying high‐grade intraepithelial lesion (HSIL) as compared to 12% in ASC‐US cases 3. Other studies have also confirmed the significance of subtyping ASC cases into ASC‐H 4–9. The majority of the previous studies are on conventional cervical smears.…”

mentioning

confidence: 85%

Generation of an atlas of the proximal femur and its application to trabecular bone analysis

Carballido‐Gamio¹,

Folkesson

Karampinos

et al. 2011

Magnetic Resonance in Med

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Automatic placement of anatomically corresponding volumes of interest and comparison of parameters against a standard of reference are essential components in studies of trabecular bone. Only recently, in vivo MR images of the proximal femur, an important fracture site, could be acquired with high-spatial resolution. The purpose of this MRI trabecular bone study was two-fold: (1) to generate an atlas of the proximal femur to automatically place anatomically corresponding volumes of interest in a population study and (2) to demonstrate how mean models of geodesic topological analysis parameters can be generated to be used as potential standard of reference. Ten females were used to generate the atlas and geodesic topological analysis models, and 10 females were used to demonstrate the atlas-based trabecular bone analysis. All alignments were based on three-dimensional (3D) multiresolution affine transformations followed by 3D multiresolution free-form deformations. Mean distances less than 1 mm between aligned femora, and sharp edges in the atlas and in fused gray-level images of registered femora indicated that the anatomical variability was well accommodated and explained by the free-form deformations.

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Atypical squamous cells, cannot exclude high‐grade squamous intraepithelial lesion: Diagnostic features in surepath™ cervical samples

Gupta

Crossley

Dudding

et al. 2012

Diagnostic Cytopathology

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This study was undertaken to identify the situations in which a diagnosis of "Atypical squamous cells, cannot exclude a high-grade squamous intraepithelial lesion (ASC-H)" is offered in SurePath™ cervical samples and to identify cytological criteria helpful in predicting high-grade disease. 2,335 (3.4%) SurePath samples reported as atypical squamous cells (ASC) over a period of 2 years, including 1,112 cases with known hrHPV status were retrieved. 105/1,112 cases were categorized into ASC-H, and slides were available for review in 88/105 cases. These 88 samples were divided into two categories based on follow-up histological outcome and hrHPV status-category A: cases with CIN2+ lesions on follow-up (n = 48) and category B: cases with ≤CIN1 lesions or hrHPV negative status (n = 40). 78% (82/105) cases of ASC-H tested positive for hrHPV. Overall CIN2+ lesions were found in 50.3% (53/105) cases. Of 88 cases reviewed, HCGs were noted in 56.3% (27/48) cases in category A and 75% (30/40) cases in category B. Dispersed metaplastic cells and scattered small atypical cells were seen in 37.5% (18/48) cases in category A and 12.5%(5/40) in category B. The majority of cases with dispersed atypical cells had <20 cells/sample and cases with HCGs had <10 HCGs per sample. The majority of the cases reported as ASC-H contained HCGs. Of these groups with nuclear crowding, disorganization and those with steep edges ("blocks") are likely to predict high-grade disease. The samples with only dispersed atypical cells had <20 cells/sample in majority of cases. In these, a disproportionate and especially high nuclear: cytoplasmic ratio and irregular chromatin were the most useful features in predicting high-grade disease.

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Borderline nuclear change, high‐grade dyskaryosis not excluded: current concepts and impact on clinical practice

Cited by 3 publications

References 18 publications

Image analysis of hyperchromatic crowded cell groups in SurePath cervical cytology

Image analysis of hyperchromatic crowded cell groups in SurePath cervical cytology

Generation of an atlas of the proximal femur and its application to trabecular bone analysis

Atypical squamous cells, cannot exclude high‐grade squamous intraepithelial lesion: Diagnostic features in surepath™ cervical samples

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