Bordetella bronchiseptica infection

Ducours, Maïlys; Rispal, P; Danjean, M.P.; Imbert, Y.; Dupont, Étienne; Traissac, E.M.; Grosleron, S.

doi:10.1016/j.medmal.2017.05.012

Cited by 10 publications

(8 citation statements)

References 7 publications

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“…Many mammals are susceptible to infection with Bb including dogs. Research has concentrated on Bb infections in pigs (atrophic rhinitis), dogs (CIRDC), laboratory animals (bronchopneumonia) and increasingly man (Woolfrey and Moody, 1991;Ducours et al, 2017). The bacterium can act as a primary pathogen in dogs (Wright et al, 1973) or cause CIRDC concurrently with other bacteria and/or viruses.…”

Section: Biology and Pathophysiology Of Pathogens In Cirdcmentioning

confidence: 99%

Aetiology of Canine Infectious Respiratory Disease Complex and Prevalence of its Pathogens in Europe

Day

Carey

Clercx

et al. 2020

Journal of Comparative Pathology

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The canine infectious respiratory disease complex (CIRDC) is an endemic worldwide syndrome involving multiple viral and bacterial pathogens. Traditionally, Bordetella bronchiseptica (Bb), canine adenovirus type 2 (CAV-2), canine distemper virus (CDV), canine herpesvirus (CHV) and canine parainfluenza virus (CPiV) were considered the major causative agents. Lately, new pathogens have been implicated in the development of CIRDC, namely canine influenza virus (CIV), canine respiratory coronavirus (CRCoV), canine pneumovirus (CnPnV), Mycoplasma cynos and Streptococcus equi subspecies zooepidemicus. To better understand the role of the different pathogens in the development of CIRDC and their epidemiological relevance in Europe, prevalence data were collected from peerreviewed publications and summarized. Evidence of exposure to Bb is frequently found in healthy and diseased dogs and client-owned dogs are as likely to be infected as kennelled dogs. Co-infections with viral pathogens are common. The findings confirm that Bb is an important cause of CIRDC in Europe. CAV-2 and CDV recovery rates from healthy and diseased dogs are low and the most likely explanation for this is control through vaccination. Seroconversion to CHV can be demonstrated following CIRDC outbreaks and CHV has been detected in the lower respiratory tract of diseased dogs. There is some evidence that CHV is not a primary cause of CIRDC, but opportunistically re-activates at the time of infection and exacerbates the disease. The currently available data suggest that CIV is, at present, neither a prevalent nor a significant pathogen in Europe. CPiV remains an important pathogen in CIRDC and facilitates co-infection with other viral and bacterial pathogens. CnPnV and CRCoV are important new elements in the aetiology of CIRDC and spread particularly well in multi-dog establishments. M. cynos is common in Europe and is more likely to occur in younger and kennelled dogs. This organism is frequently found together with other CIRDC pathogens and is significantly associated with more severe respiratory signs. S. zooepidemicus infection is not common and appears to be a particular problem in kennels. Protective immunity against respiratory diseases is rarely complete, and generally only a reduction in clinical signs and excretion of pathogen can be achieved through vaccination. However, even vaccines that only reduce and do not prevent infection carry epidemiological advantages. They reduce spread, increase herd immunity and decrease usage of antimicrobials. Recommending vaccination of dogs against pathogens of CIRDC will directly provide epidemiological advantages to the population and the individual dog.

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Section: Biology and Pathophysiology Of Pathogens In Cirdcmentioning

confidence: 99%

Aetiology of Canine Infectious Respiratory Disease Complex and Prevalence of its Pathogens in Europe

Day

Carey

Clercx

et al. 2020

Journal of Comparative Pathology

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“…While this is a common pathogen in other animals, it is a rare cause of infection in humans due to the bacterium's predilection for animal respiratory epithelium [13]. Cases of human infection mostly occur in immunocompromised hosts, patients with a chronic respiratory illness associated with impaired respiratory barriers such as cystic fibrosis, and the elderly [[14], [15], [16], [17], [18], [19]]. Although previously reported in non-lung solid organ transplant recipients and in pediatric lung transplant recipients [16,18,19], to the best of our knowledge this is the first account of infection with B. bronchiseptica in an adult lung transplant recipient.…”

Section: Discussionmentioning

confidence: 99%

Rapidly progressive interstitial lung disease due to anti-melanoma differentiation associated protein-5 requiring a bilateral lung transplant, and complicated by kennel cough

Deitchman¹,

Kalchiem‐Dekel²,

Todd³

et al. 2019

Respiratory Medicine Case Reports

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The association between inflammatory myopathies anti-synthetase syndrome and interstitial lung disease has been recognized since the 1950s. Patients generally present with gradual onset of symptoms and slow progression of fibrosis over months to years. Herein, we describe a previously well 51-year-old man who presented with three months of progressive small joint arthritis, cough, dyspnea, and eventually hypoxemic respiratory failure following a viral prodrome. He continued to decompensate despite high dose corticosteroids and mycophenolate mofetil, ultimately requiring extracorporeal membranous oxygenation as a bridge to bilateral lung transplantation. Clinically amyopathic dermatomyositis (CADM) was confirmed through serum positivity for anti-Melanoma Differentiation Associated Protein-5 (MDA-5) antibody. Interestingly, his post-operative course was complicated by a zoonotic infection with Bordetella bronchiseptica. This case highlights the importance of identifying rare autoimmune diseases, and the utility of transfer to a lung transplant center.

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“…In comparison to other Bordetella spp ., its nutritional requirements are simple [1] . B. bronchiseptica plays an important role as a primary and secondary pathogen of the upper respiratory tract in several mammals [2] but is most important and best described in dogs and in pigs [3] . We discuss the case of a male pig breeder who came with symptoms suggestive of respiratory infection, initially misdiagnosed as pulmonary tuberculosis, later identified with B. bronchiseptica pneumonia and effectively treated with fluoroquinolones and doxycycline.…”

Section: Introductionmentioning

confidence: 99%