Boric Acid Catalysed Synthesis of α-Aminonitriles by a Three-Component Reaction at Room Temperature

Abstract

A simple, efficient, and cost-effective method has been developed for the one-pot, three-component condensation reaction of trimethylsilyl cyanide, aldehydes and aromatic amines using boric acid as a heterogeneous solid acid catalyst, under solvent-free conditions. α-Aminonitriles were synthesised relatively quickly in good yields at room temperature.

One-pot three-component synthesis of α-aminonitriles using sodium dihydrogen phosphate as a catalyst at room temperature

“…Considering the biomedical applications of αaminonitrile derivatives and in the perpetuation of the development of practical, convenient and environmentally-friendly procedures for one-pot multi-component reactions, [23][24][25][26][27] we were prompted to exploit the catalytic potential of sodium dihydrogen phosphate for a facile and efficient three-component synthesis of functionalized αaminonitriles through a multicomponent reaction of aldehyde, amine, and TMSCN (Scheme 1). Our literature survey at this stage revealed that sodium dihydrogen phosphate (NaH 2 PO 4 ) has not been utilized for the synthesis of α-aminonitriles.…”