Reduction of carbon footprint generated by organic solvents via replacing them with greener solvents is of great interest in recent times. Herein, we report a Michael addition reaction of indoles to α, β-unsaturated ketones, and nitrostyrene using reusable and low toxic eucalyptol as a green solvent, and Fe(OTs) 3 ⋅ 6H 2 O as green catalyst. This methodology offers broad substrate scope and excellent yields (up to 90 %) in short reaction times.

An efficient and environmentally friendly synthetic protocol has been presented to synthesize α‐aminonitriles from aldehydes, amines and trimethylsilyl cyanide using 10 mol% iron(III) tosylate hexahydrate (Fe(OTs)3 ⋅ 6H2O) as a green catalyst in aqueous media through one‐pot procedure. Iron(III) tosylate hexahydrate is a promising catalyst, introduced first time for the synthesis of α‐aminonitriles in aqueous media as it is commercially available, inexpensive, non‐toxic, operational simplicity and has a short reaction time with excellent yields is awaited to contribute to the development of novel green protocol for the synthesize α‐aminonitriles.

The synthesis of nitrogen containing heterocycles is of particular interest in the pharmaceutical industry due to the range of biological activities exhibited by such compounds. Their synthesis using multicomponent reactions saves steps and minimizes waste generation. The bismuth (III) chloride multicomponent synthesis of a series of hexahydroimidazo[1, 2-a]pyridines is reported. Bismuth (III) compounds are especially attractive from a green chemistry perspective because they are remarkably nontoxic, non-corrosive and relatively inexpensive. The reported method avoids chromatography and an aqueous waste stream to afford the products in a very mass efficient manner.