Boric Acid for Recurrent Vulvovaginal Candidiasis: The Clinical Evidence

Abstract

Our findings suggest that boric acid is a safe, alternative, economic option for women with recurrent and chronic symptoms of vaginitis when conventional treatment fails because of the involvement of non-albicans Candida spp. or azole-resistant strains.

Chronic suppurative otitis media due to nontuberculous mycobacteria: A case of successful treatment with topical boric acid

“…It appears to exert its antimicrobial activity in a concentrationdependent manner, but its precise antibacterial and antifungal mechanisms of action are not known. Boric acid powder has also been used successfully in suppository form for the treatment of vulvovaginal candidiasis, including for recurrent or chronic cases due to azole-resistant Candida species [9].…”

Future therapies targeted towards eliminatingCandidabiofilms and associated infections

“…BA has also been used as an alternative therapeutic agent for recurrent vulvovaginal candidiasis [168]. Clinical studies that have compared fluconazole and BA in the management of vulvovaginal candidiasis indicate that it is as effective as fluconazole in managing the condition, with the added advantages such as lower cost, ready availability and safety [169,170].…”

Recurrent vulvovaginal candidiasis

“…Failure to eradicate C.glabrata in symptomatic women justifies additional efforts which include intravaginal nystatin, flucytosine and amphotericin B and combinations thereof should be attempted (54). There are however few published studies on the efficacy, safety or even need for long term maintenance regimen with boric acid or polyene agents (55,56). Not infrequently chronic and RVVC due to C.glabrata occurs in women with uncontrolled type 2 diabetes and without control of hyperglycemia, eradication of C.glabrata is unlikely.…”