Boric Acid Irrigation as an Adjunct to Mechanical Periodontal Therapy in Patients With Chronic Periodontitis: A Randomized Clinical Trial

Abstract

The results of this study suggest that boric acid could be an alternative to chlorhexidine, and it might be more favorable because boric acid was superior in whole-mouth BOP as well as PD and CAL reduction for moderate pockets in early time periods.

Clinical efficacy of subgingivally‐delivered 0.75% boric acid gel as an adjunct to mechanotherapy in chronic periodontitis: A randomized, controlled clinical trial

“…Based on a previous study, in which 0.75% boric acid in the form of solution was used for subgingival irrigation, and where real‐time cell analysis was carried out to examine the cytotoxic effect of a 0.75% concentration of boric acid on human gingival fibroblasts (HGF) and human periodontal ligament fibroblasts (HPDLF), it was found that a 0.75% concentration of boric acid is non‐toxic to HGF and HPDLF . Based on the results of in vitro cytotoxicity experiments performed in a previous study, we decided to use a 0.75% concentration of boric acid (pH 4.9) in this clinical study, but in gel form, for subgingival delivery.…”

“…It has also been shown that the systemic administration of boric acid in rats affects receptor activator of nuclear factor kappa‐B ligand/osteoprotegerin balance, thus possibly reducing alveolar bone loss by periodontal disease . In a recent study, it was found that subgingival irrigation with boric acid (0.75%) as an adjunct to mechanotherapy in CP patients leads to significant reduction in plaque index (PI), bleeding on probing (BoP), and probing depth (PD), and a gain in clinical attachment level (CAL) …”

Boric acid gel as local drug delivery in the treatment of class II furcation defects in chronic periodontitis: a randomized, controlled clinical trial

“…Based on a previous study, in which 0.75% BA in the form of a solution was used for subgingival irrigation, a real‐time cell analyzer was used to examine the cytotoxic effect of a 0.75% concentration of BA on human gingival fibroblasts (HGF) and human periodontal ligament fibroblasts (HPDLF). It was found that a 0.75% concentration of BA is non‐toxic to HGF and HPDLF.…”

“…suggested that systemically‐administered BA can reduce alveolar bone loss in the diabetic rat model . AN0128 has demonstrated in vitro activity against several bacteria associated with periodontal disease, namely Prevotella intermedia , Porphyromonas gingivalis , Eubacterium nodatum , and Treponema denticola . In addition, AN0128 has shown inhibition of lipopolysaccharide‐induced tumor necrosis factor‐α release from human monocytes, and thus, this compound exhibits both antibacterial and anti‐inflammatory activity .…”

Effects of vector ultrasonic system debridement and conventional instrumentation on the levels of TNF-α in gingival crevicular fluid of patients with chronic periodontitis

“…Based on conventional periodontal treatment which includes scaling and root planing (S/RP), numerous studies have reported favorable developments in both the clinical and microbial parameters. 5,6 In spite of the successful clinical outcomes, hand instrumentation has several disadvantages, including being time-consuming and exhausting for patients as well as clinicians. 7 Vector ultrasonic system (VUS) (Dürr Dental, BietigheimBissingen, Germany) is used non-surgically for the procedures of subgingival debridement.…”