Borna disease virus antibodies and the deficit syndrome of schizophrenia

Waltrip, Royce W.; Boyer, Robert; Carpenter, William T.; Kirkpatrick, Brian; Summerfelt, Ann; Breier, Alan; Rubin, Steven A.; Carbone, Kathryn M.

doi:10.1016/s0920-9964(96)00114-4

Cited by 76 publications

(42 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The clinical features of these patients contrast with the observations by Waltrip et al, who reported that BDV seropositivity is associated with deficit symptoms in schizophrenic patients. 23 Prevalence of BDV RNA in mental health workers Seven out of 45 mental health workers were identified as having BDV RNA in their PBMCs. Six subjects were positive for BDV p24 RNA, while one subject was positive for BDV p40 RNA.…”

Section: Clinical Characteristics Of Bdv-positive Patientsmentioning

confidence: 99%

Detection of Borna disease virus RNA from peripheral blood cells in schizophrenic patients and mental health workers

Yl²,

et al. 1999

Mol Psychiatry

View full text Add to dashboard Cite

Accumulating evidence suggests that Borna disease virus (BDV), a neurotropic, negativestranded RNA virus, might be associated with certain human mental disorders. Several research groups reported that psychiatric patients had a significantly higher prevalence of BDV serum antibodies than normal controls. In addition, a significantly higher presence of BDV RNA from peripheral blood cells was identified in mental patients than in controls. In our previous study, we first identified the presence of BDV serum antibodies in a cohort of Chinese schizophrenic patients from Taiwan, and we also demonstrated a significantly higher seroprevalence of BDV antibodies among schizophrenic patients than in non-psychiatric controls. Prompted by the positive seroepidemiological result, we set out to investigate the detection of BDV RNA from the peripheral blood cells of our schizophrenic patients. By using the reverse transcription-polymerase chain reaction (RT-PCR) method, 10 out of 74 Chinese schizophrenic patients from Taiwan were found to have BDV RNA in their blood cells, whereas only one out of 69 controls was positive. The BDV RNA detection rate among schizophrenic patients was significantly higher than that in controls (14% vs 1.4%, P Ͻ 0.01). Furthermore, we studied the BDV RNA detection rate among mental health workers, and seven out of 45 mental health workers were found to have positive results. The prevalence rate was significantly higher than that in normal controls (15% vs 1.4%, P Ͻ 0.001), which lends further support to our previous finding that mental health workers have a significantly higher presence of BDV serum antibodies. In summary, our data support the finding that BDV infection might be a contributory factor to the pathogenesis of schizophrenia in the Chinese population.

show abstract

Section: Clinical Characteristics Of Bdv-positive Patientsmentioning

confidence: 99%

Detection of Borna disease virus RNA from peripheral blood cells in schizophrenic patients and mental health workers

Yl²,

et al. 1999

Mol Psychiatry

View full text Add to dashboard Cite

show abstract

“…[3][4][5][6] Recent studies have provided evidence to indicate that Borna disease virus (BDV) may play an important role in the pathogenesis of schizophrenia. [7][8][9][10] Borna disease virus is a neurotropic, enveloped, negative-stranded RNA virus, which was first recog-nized as the infectious agent of an horse encephalitis endemic in eastern Germany. Several groups of researchers have demonstrated that patients with neuropsychiatric disorders have a higher rate of serum antibodies against BDV-specific nucleoprotein (40 kD, p40) and/or phosphoprotein (24 kD, p24), [11][12][13][14][15] suggesting that human neuropsychiatric disorders may be associated with BDV infection.…”

Section: Introductionmentioning

confidence: 99%

High seroprevalence of Borna virus infection in schizophrenic patients, family members and mental health workers in Taiwan

Chen

Yl²,

Fc³

et al. 1999

Mol Psychiatry

View full text Add to dashboard Cite

Borna disease virus (BDV), a negative-strand RNA virus, has been reported to be associated with severe psychiatric disorders. The association is mainly based on the findings that patients with schizophrenia and depression have a higher seroprevalence rate of BDV-specific antibodies than controls. In addition, psychiatric patients were also found to have a higher detection rate of BDV transcripts in their blood than controls. By using an improved Western blot analysis, we first demonstrated that Chinese schizophrenic patients from Taiwan also have a higher seroprevalence of BDV-specific antibodies than controls (12.1% vs 2.9%, P Ͻ 0.001), providing support to the positive association between BDV and psychiatric disorders in our population. Because of the contagious nature of viral infection, we further examined patients' family members and mental health workers, who have close contact with patients. We found that both groups also have a higher seroprevalence of BDV-specific antibodies, 12.1% and 9.8%, respectively, than controls. This finding provides some evidence for a possible human-to-human transmission of Borna disease virus. Our finding needs further independent verification from other research groups and the clinical relevance of this preliminary observation deserves further study.

show abstract

“…Waltrip and colleagues detected a higher rate of BDV seropositivity in schizophrenic patients with deficit syndrome than in patients with non-deficit syndrome (Waltrip et al, 1997). …”

Section: Bdv Positivity and Psychopathologymentioning

confidence: 97%

“…The rate of BVD positivity in psychiatric patients ranged from negative to highly positive (almost 100% in patients with affective disorders). Several researchers found a significant association between BDV positivity (levels of BDV Ag and CIC) and severity of the psychopathology (Bode et al, 2001;Rackova et al, 2009) and between BDV seropositivity and negative symptoms in schizophrenia (Iwahashi et al, 1998;Waltrip et al, 1997). Borna disease infection is associated with a chronic course of the disease without full remission and with recurring psychiatric disorders.…”

Section: Bdv and Psychiatric Disordersmentioning

confidence: 99%

Borna Disease Virus and Psychiatric Disorders: Can Viruses Influence Psychiatric Disorders?

Racková¹,

Janů²

2011

Psychiatric Disorders - Worldwide Advances

View full text Add to dashboard Cite

Borna disease virus antibodies and the deficit syndrome of schizophrenia

Cited by 76 publications

References 28 publications

Detection of Borna disease virus RNA from peripheral blood cells in schizophrenic patients and mental health workers

Detection of Borna disease virus RNA from peripheral blood cells in schizophrenic patients and mental health workers

High seroprevalence of Borna virus infection in schizophrenic patients, family members and mental health workers in Taiwan

Borna Disease Virus and Psychiatric Disorders: Can Viruses Influence Psychiatric Disorders?

Contact Info

Product

Resources

About